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Biomedical subjects

G R Holmes

Publications and source records attributed to G R Holmes.

At least 37 records · Page 2Linked to original sources
PubMed1984

Parent MMPI critical item and clinical scale changes in the 1970s.

The Child and Adolescent Psychiatry Service of the William S. Hall Psychiatric Institute, Columbia, South Carolina, routinely administers the MMPI to the parents of children and adolescents in outpatient psychiatric treatment. The MMPI data obtained from parents during the (1970-74) and (1975-79) periods (N = 342) have been analyzed from two perspectives. MMPI critical item endorsement and MMPI clinical scale changes have been evaluated statistically through a comparison of parents in the two time periods. Both the increase in clinical scale elevations and shift in critical item endorsement suggest a parent population in which mothers are suffering considerably more psychological distress or psychopathology than fathers during the last 5 years. The findings indicate the need for cross-clinic replications of the present investigation in order to establish the reliability of the current findings.

Adolescent↗
PubMed1984

Some important epochs in medicine.

One of the problems in attempting to chronicle briefly the great moments in the history of medicine is that, like the healing process itself, turning points are difficult to pinpoint. There have been surprisingly few "eurekas." In addition, unlike the history of corporate bodies or institutions (such as the church and the nation state) there is no continuous record, no deliberate account. However, the lack of such systemic recording has had its advantage in excluding the element of mythology and myopic partisanship. Since we must choose some kind of framework, we have (in addition to the arbitrary division into Ancient, Medieval, Modern Renaissance, and Enlightenment periods) taken a page from the works of August Comte, the eminent 19th Century philosopher, who divided all of history into three states: theologic (fictional), metaphysical (abstract), and scientific (positivistic). The division is convenient because it not only demonstrates the timelessness and transcendence of medicine, but it also makes it obvious that the cyclic nature of medical interests continues, even today, to offer a theologic, metaphysical, and scientific approach to the problems of health care.

Chemistry↗
PubMed1984

Quality and applicability of an undergraduate psychopharmacy rotation: a survey of pharmacy students.

This paper details the results of a study of an undergraduate psychopharmacy rotation in an inpatient hospital setting and assesses its influence on pharmacy graduates careers in pharmacy. Significant features of the rotation include the students' participation in patient care activities and patient education about medications, as well as presentation of case histories. The students also took medication histories and revised patients' charts with the preceptor. Graduates of this program were sent questionnaires to assess their impressions of the rotation for quality of experience and for applicability to their pharmacy position. Ninety-four percent of the students responding worked as pharmacists and all reported dispensing psychoactive agents. Three-fourths of the respondents gave the program a positive rating for its influence on training in customer/patient relations and communications.

Clinical Clerkship↗
PubMed1981

Behavioral science in medical education: an updated bibliography.

Holmes, et al. in 1979 compiled 125 studies in a bibliography of behavioral science in undergraduate and graduate education. Since 1979, 75 additional studies of behavioral science in medical education have been identified. The current updated bibliography contains 200 entries. Foreign medical journals, Index Medicus, and Psychological Abstracts were reference sources for the bibliography.

Behavioral Sciences↗
PubMed1977

Responses by graduates to memory of their internship in clinical psychology.

This study is a two-part investigation of clinical psychology internship training at the William S. Hall Psychiatric Institute. The first part surveyed 25 intern graduates to identify the relationship between experiences as an intern and current professional activities. Results are related to findings from other research in training clinical psychologists. The second part pertains to suggestions of intern graduates for specific additions and revisions of intership training at the Institute.

Attitude↗
PubMed1976

Effect of trypsin on rabbit skeletal muscle alpha-actinin.

5 min of tryptic digestion of purified rabbit skeletal alpha-actinin decreases by approximately 75% the ability of alpha-actinin to cross-link F-actin filaments as measured viscometrically at 27 degrees C, but has little effect on the sedimentation coefficient of alpha actinin at 20 degrees C or an alpha-actinin's ability to increase the Mg2+-modified ATPase activity and rate of turbidity increase of reconstituted actomyosin suspensions. Twenty to sixty min of trypsin treatment reduces the sedimentation coefficient of alpha-actinin and destroys much of alpha-actinin's ability to increase the MG2+-modified ATPase and rate of turbidity increase of reconstituted actomyosin suspensions. Therefore, the ability of alpha-actinin to increase the rate of in vitro measures of muscle contraction may not result directly from alpha-actinin's ability to cross-link F-actin filaments. Trypsin does not split alpha-actinin into large fragments as it does myosin. Previous studies have shown that 35 to 65% of total tryptic-susceptible peptide bonds in alpha-actinin are split after 60 min of incubation with trypsin and that 30% of these bonds split in 60 min are cleaved during the first 5 min in a rapid reaction. That splitting of this group of peptide bonds has little effect on the sedimentation coefficient of alpha-actinin indicates that these bonds are located in a region of the alpha-actinin molecule where noncovalent forces are strong enough to maintain conformation of the native alpha-actinin molecule even after these bonds have been split. This ostensible segregation of alpha-actinin's ability to cross-link F-actin filaments from its ability to increase rate of in vitro assays of contraction by tryptic digestion may suggest that alpha-actinin could have at least two different physiological roles: (1) to bind actin filaments to each other or to basal structures, and (2) to enhance the effectiveness of actin in supporting movement.

Actinin↗