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Biomedical subjects

G R Giles

Publications and source records attributed to G R Giles.

At least 145 records · Page 8Linked to original sources
PubMed1969

Effect of pH changes on the cardiac sphincter.

In 16 normal subjects the pressure characteristics of the cardiac sphincter have been examined. The effect of perfusing the gastric aspect of the sphincter mucosa has been studied by comparing the effects of saline with those of solutions where pH ranged from 1.0 to 8.0. Acid perfusion produced an increase in sphincteric pressure, particularly at pH 3.0. This suggests that a physiological mechanism exists which can increase the barrier pressure to gastrooesophageal reflux during periods of active secretion of the stomach, as occurs in digestion.

Atropine↗
PubMed1969

Action of gastrin on the lower oesophageal sphincter in man.

Both hog gastrin and synthetic gastrin stimulate the cardiac sphincter to increase tone and augment the resistance to reflux. Endogenous gastrin has a similar effect, and gastrin also stimulates the secretion of acid which has also been found to increase the resistance of the sphincter, but the effect of gastrin appears to be independent of the secretory stimulus.

Cardia↗