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Biomedical subjects

G R Gallo

Publications and source records attributed to G R Gallo.

62 records · Page 4Linked to original sources
PubMed1976

Progression to uremia after remission of acute poststreptococcal glomerulonephritis.

Whether or not poststreptococcal glomerulonephritis advances over the long term to uremia remains an unsettled issue. We documented ultimate progression to renal failure in six patients who were observed at onset with the typical clinical and morphologic features of acute nephritis after proved beta-hemolytic streptococcal infection. Within one year, renal function returned essentially to normal in all, as the proliferative changes in glomeruli subsided, Subsequently, increasing renal failure developed in these patients over periods ranging from two to 12 years, during which all were hypertensive. As the renal disease progressed, glomeruli showed increasing sclerosis in the absence of proliferation, and fibrohyaline thickening of renal arterioles appeared.

Acute Disease↗
PubMed1976

Production of experimental toxemia in the pregnant rabbit.

Experimental toxemia of pregnancy was induced in 51 of 122 rabbits by constriction of the aorta below the renal arteries. The approach was extraperitoneal and dependent on the accuracy in calibrating this stricture between 0.6 and 1.0 mm. Experimental toxemia in the rabbit was characterized by hypertension, proteinuria, weight gain, and reduced weight of the fetus. Blood pressure and blood flow studies distal to the aortic constriction demonstrated a marked diminution of blood supply below the constriction. The light microscopic changes in the kidneys and in the liver were similar to those of human toxemia. The electron microscopic changes consisted of endothelial swelling and subendothelial deposits. In a separate experiment, 22 pregnant rabbits near term had an aortic constriction varying between 0.6 and 1.0 mm. This constriction lasted 4 to 12 days. Glomerular deposits of fibrinogen were demonstrated by immunofluorescence in 20 of 22 animals. The intensity of the immunofluorescence was related to the severity and duration of the aortic stricture.

Animals↗
PubMedDate not supplied

Rifampin-induced nephrotic syndrome and acute interstitial nephritis.

The occurrence of renal insufficiency associated with heavy glomerular proteinuria during the course of continuous rifampin therapy in a patient with pulmonary tuberculosis is reported. Renal biopsy demonstrated acute interstitial nephritis, normal glomerular histology, effacement of glomerular epithelial cell foot processes, and electron-dense deposits in mesangial matrix and subendothelial and paramesangial sites. Discontinuation of rifampin was followed by improvement in renal function and abatement of proteinuria. We call attention to the broad clinical and morphologic spectrum of nephrotoxicity which may be induced by rifampin and a variety of other drugs.

Acute Disease↗
PubMedDate not supplied

Glomerular deposition diseases: insights into mechanisms.

Recent experimental studies demonstrate that glomerular basement membrane immune deposits may be formed locally or by deposition of intact complexes from the circulation. Electrostatic interactions may play a role in both of these mechanisms and may account, at least in part, for differences in patterns of localization in the various deposition diseases.

Antigen-Antibody Complex↗