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Biomedical subjects

G R Brisson

Publications and source records attributed to G R Brisson.

At least 73 records · Page 4Linked to original sources
PubMed1979

[Bone maturity and physical performance].

We have examined the relation between physical performance (as measured with the CAHPER tests), bone age (Greulich and Pyl's wrist evaluation) and dental age (Garn's method). Our study included 164 boys and 149 girls aged from 7 to 11. In spite of interesting significant simple correlation between most of the CAHPER tests and bone age measurements for the pre-pubescent period, the latter remains of negligible value in predicting physical performance in the studied children when variables like chronological age, body height and body weight are already included in the prediction equation.

Age Determination by Skeleton↗
PubMed1978

Body temperatures in relation to heart rate for workers wearing impermeable clothing in a hot environment.

Thermal reactions and heart rate were measured for men wearing impermeable clothing in a hot environment. Even at rest, the Ts increase was remarkable. At the 30th minute, Ts reached 37.2 +/- .4 degrees (+/- SD). Experimental walking (wearing impermeable clothes) occasioned significant (p less than .001) rises in thermal reactions and HR in comparison to control walking; Tr, Tb, Ts at the 30th minute were 38.4, 38.4, 38.1 degree C respectively, and HR was 162 beats/min. No plateau for these responses was reached during 30 minutes of experimental walking. Tr continued to rise after the subjects stopped exercising. The regression equation of Tr on HR in experimental walking differed from that of control walking. If Tr is used as an index for work safety, a lower Tr is needed under such severe conditions.

Adolescent↗
PubMed1972

The stimulus-secretion coupling of glucose-induced insulin release. VII. A proposed site of action for adenosine-3',5'-cyclic monophosphate.

Glucose-induced insulin release is thought to result from the following sequence of events in the beta cell: glucose metabolism leading to the production of a metabolic signal, net calcium uptake by the beta cell in response to the signal, and interaction between calcium and a microtubular-microfilamentous system, leading to emiocytosis of the secretory granules. Dibutyryl-cyclic AMP (db-cAMP) and theophylline are known to potentiate glucose-induced insulin release, their insulinotropic action being most marked at high glucose concentrations. Based on the above mentioned concepts, it was considered in the present experiments that the primary site of action of cAMP in the beta cell could correspond to either a facilitation of glucose metabolism, a modification of calcium distribution, or an interaction with the microtubular-microfilamentous system. The first of these hypotheses appeared unlikely because db-cAMP and theophylline, in sharp contrast with other agents known to affect glucose metabolism in the beta cell, did not modify glucose-induced calcium uptake by isolated islets incubated at high glucose concentrations. The last hypothesis also appeared unlikely since theophylline did not interfere with the deleterious effect of colchicine on the microtubular system, and since vincristine or colchicine did not differentially affect the respective insulinotropic action of glucose and theophylline. An effect of cAMP upon calcium distribution in the beta cell was suggested by the following findings. Whereas glucose and leucine were unable to promote insulin release in the absence of extracellular calcium, the addition of db-cAMP or theophylline to the calcium-depleted media partially restored theinsulinotropic action of glucose and leucine. Moreover, theophylline caused a dramatic increase in (45)Ca efflux from perifused islets, even in the absence of glucose. It is concluded that the insulinotropic action of cAMP could be due to a glucose-independent translocation of calcium within the beta cell, from an organelle-bound pool to a cytoplasmic pool of ionized calcium readily available for transport across the cell membrane.

Animals↗