Biomedical subjects

G R Alexander

Publications and source records attributed to G R Alexander.

At least 55 records · Page 3Linked to original sources

PubMed1995

Similarities and disparities in maternal risk and birth outcomes of white and Japanese-American mothers.

This study compares the maternal sociodemographic and prenatal care characteristics and birth outcomes of US resident white and Japanese-American mothers, using data from the state of Hawaii. The specific focus is to determine to what extent these factors can explain variations in newborn maturity and mortality indicators. Single livebirths to resident, non-military dependent white and Japanese-American mothers were selected for analysis from the 1979-1990 linked livebirth-infant death files from Hawaii. Compared with white mothers, Japanese-American mothers were significantly more likely to be married, age 18 years and older, have higher educational attainment, and have adequate prenatal care utilisation. The majority of Japanese-American mothers were born in Hawaii, while the majority of white mothers were born on the US mainland. The mean birthweight of Japanese-American infants was 200 g lighter than that of white infants. Infant mortality rates (IMRs) for both groups were below the US Year 2000 Health Objective. After controlling for maternal sociodemographic and prenatal care factors with logistic regression, Japanese-American infants had significantly higher risks of low birthweight, preterm and very preterm birth and of being small-for-gestational age. These findings indicate that populations with preferential maternal sociodemographic and prenatal care risk indicators may still exhibit higher low birthweight percentages, but achieve comparatively low IMRs.

Adolescent↗

PubMed1995

Adolescent parity and infant mortality, Minnesota, 1980 through 1988.

The association of parity and infant mortality was studied using linked birth-death files for 46,985 infants born to 11- to 19-year-old Minnesota residents between 1980 and 1988. Compared with infants of primiparas, infants of multiparas were at twice the risk for infant and postneonatal death but at no increased risk for neonatal death. They were also at two to three times the risk for deaths due to accidents, infections, and sudden infant death syndrome. The higher sociodemographic disadvantage and poorer prenatal care of multiparas did not explain the excess infant mortality risk that was concentrated in causes of death that are potentially preventable through primary care and parent education.

Adolescent↗

PubMed1995

The role of prenatal care in preventing low birth weight.

Prenatal care has long been endorsed as a means to identify mothers at risk of delivering a preterm or growth-retarded infant and to provide an array of available medical, nutritional, and educational interventions intended to reduce the determinants and incidence of low birth weight and other adverse pregnancy conditions and outcomes. Although the general notion that prenatal care is of value to both mother and child became widely accepted in this century, the empirical evidence supporting the association between prenatal care and reduced rates of low birth weight emerged slowly and has been equivocal. Much of the controversy over the effectiveness of prenatal care in preventing low birth weight stems from difficulties in defining what constitutes prenatal care and adequate prenatal care use. While the collective evidence regarding the efficacy of prenatal care to prevent low birth weight continues to be mixed, the literature indicates that the most likely known targets for prenatal interventions to prevent low birth weight rates are (1) psychosocial (aimed at smoking); (2) nutritional (aimed at low prepregnancy weight and inadequate weight gain); and (3) medical (aimed at general morbidity). System level approaches to impact the accessibility and the appropriateness of prenatal health care services to entire groups of women and population-wide health promotion, social service, and case management approaches may also offer potential benefits. However, data on the effectiveness of these services are lacking, and whether interventions focused on building cohesive, functional communities can do as much or more to improve low birth weight rates as individualized treatments has yet to be explored. The ultimate success of prenatal care in substantially reducing current low birth weight percentages in the United States may hinge on the development of a much broader and more unified conception of prenatal care than currently prevails. Recommendations for actions to maximize the impact of prenatal care on reducing low birth weight are proposed both for the public and for the biomedical, public health, and research communities.

Female↗

PubMed1994

Hyaline membrane disease in black newborns: does fetal lung maturation occur earlier?

Debate has developed among several authors about possible accelerated maturation of black fetuses in comparison with whites. In Guadeloupe, French West Indies, where 85% of the population is of black African-American origin, it has been noted that the incidence of hyaline membrane disease (HMD) represents a significant drop beginning after the 32nd week of gestation. Over a 3-year period, 419 black low-birthweight singleton newborns were admitted in the University Hospital's Neonatal Department covering 70% of all births of the island. The incidence of HMD was 50% among very low birthweight (< 1500 g) and 8.3% among moderate low birthweight (> or = 1500 g; P < 0.001). The incidence of HMD was 48.8% among the very preterm (< 32 weeks) and 7.8% (26/331) among the moderate preterm (> or = 32 weeks; P < 0.001). These differences were similar for appropriate for gestational age and small for gestational age infants. Significant differences remained after controlling for several maternal risk factors. These results suggest that the 32nd week of gestation represents a significant drop in the risk for respiratory distress syndrome in black premature compared with that reported in literature on European infants (34th week) and therefore may implicate different obstetrical decisions in the management of critical pregnancies in this population.

Black or African American↗

PubMed1994

Relation of the content of prenatal care to the risk of low birth weight. Maternal reports of health behavior advice and initial prenatal care procedures.

OBJECTIVE: Numerous studies have found a relationship between the quantity of prenatal care received and birth outcomes. Few studies have had the opportunity to examine the content of prenatal care. This study examined the relationship between two components of the content of prenatal care: maternal reports of health behavior advice received and initial prenatal care procedures performed during the first two visits and low birth weight in a national sample of women. Advice and initial procedures were categorized based on the recommendations of the US Public Health Service Expert Panel on the Content of Prenatal Care. DESIGN: Interview survey of a nationally representative sample of women who had live births in 1988. PARTICIPANTS: A total of 9394 women, with data from the National Maternal and Infant Health Survey. MAIN OUTCOME MEASURE: Low birth weight (< 2500 g) as reported on the birth certificate. RESULTS: After controlling for other sociodemographic, utilization, medical, and behavioral factors, women who reported not receiving all the types of advice recommended by the Expert Panel on the Content of Prenatal Care were more likely to have a low-birth-weight infant compared with women who reported receiving the optimal level of advice (odds ratio = 1.38; 95% confidence interval, 1.18 to 1.60). There were no differences between women who reported receiving all the recommended initial prenatal care procedures and those who reported not receiving all recommended prenatal care (odds ratio = 1.00; 95% confidence interval, 0.87 to 1.14). CONCLUSION: These data suggest that women who report receiving sufficient health behavior advice as part of their prenatal care are at lower risk of delivering a low-birth-weight infant.

Female↗

PubMed1994

Racial disparities in reported prenatal care advice from health care providers.

OBJECTIVES: The relationship between certain maternal behaviors and adverse pregnancy outcomes has been well documented. One method to alter these behaviors is through the advice of women's health care providers. Advice from providers may be particularly important in minority populations, who have higher rates of infant mortality and prematurity. This study examines racial disparities according to women's self-report of advice received from health care providers during pregnancy in four areas: tobacco use, alcohol consumption, drug use, and breast-feeding. METHODS: Health care providers' advice to 8310 White non-Hispanic and Black women was obtained from the National Maternal and Infant Health Survey. RESULTS: After controlling for sociodemographic, utilization, and medical factors, Black women were more likely to report not receiving advice from their prenatal care providers about smoking cessation and alcohol use. The difference between Blacks and Whites also approached significance for breast-feeding. No overall difference was noted in advice regarding cessation of drug use, although there was a significant interaction between race and marital status. CONCLUSIONS: These data suggest that Black women may be at greater risk for not receiving information that could reduce their chances of having an adverse pregnancy outcome.

Adolescent↗

PubMed1994

The perinatal and infant health status of Native Hawaiians.

Hawaii vital record data for 1979 through 1990 were analyzed to examine potentially differing relationships between maternal and infant risks and outcomes in native Hawaiian and White infants. Despite high rates of inadequate prenatal care and teenage and unmarried childbearing, the Hawaiian low-birth-weight rate was below the US average. Hawaiian infants experienced an elevated risk of mortality, particularly among those of normal birthweight during the postneonatal period. Public health initiatives to reduce infant mortality must go beyond preventing teenage pregnancy and low birthweight to address Hawaiian infants' unique pattern of risk factors and the social and economic environment in which such risks abound.

Adolescent↗

PubMed1994

Prenatal care utilization in Minnesota. Patterns of concern, areas for improvement.

We conducted an analysis of prenatal care utilization among Minnesota resident mothers for the years 1990 to 1991 to determine why this state ranks poorly in prenatal care use while its infant mortality rate is one of the lowest in the nation. We found that 6% of women began care in the first trimester yet did not receive an adequate number of visits. These women were more likely to deliver preterm, low birthweight infants than women who started care later. Fifteen percent of women had records missing important data, and these women also had higher rates of poor pregnancy outcomes. Our findings have implications for maternal outreach and follow-up efforts and suggest potential benefits from private and public health collaborations. In addition, efforts to improve the quality of data reporting should begin immediately.

Adolescent↗

PubMed1993

Hyaline membrane disease: the role of ethnicity and maternal risk characteristics.

OBJECTIVE: Our objective was to explore the association between maternal ethnicity and maternal antepartum complications of pregnancy, maternal sociodemographic factors, and newborn characteristics with the incidence of hyaline membrane disease. STUDY DESIGN: By using a retrospective cohort analysis the incidence of hyaline membrane disease was determined for 2295 preterm infants. The study population consisted of all live, inborn infants delivered vaginally from 1982 to 1987. Statistical differences were assessed by use of chi 2 and Student's t tests. A logistic regression procedure determined the relationship of ethnicity and hyaline membrane disease after the study was controlled for all other significant population differences. RESULTS: The differences between black and white populations in marital status, were statistically significant years of education, prolonged rupture of membranes, anemia, and chronic hypertension were statistically significant. Infants of black mothers were diagnosed with hyaline membrane disease less often than infants of white mothers (overall and at each gestational age interval). After the study was controlled for population differences, infants of black mothers were still found to experience hyaline membrane disease less often. CONCLUSION: These data suggest that hyaline membrane disease occurs less frequently, is less severe, and is accompanied by fewer related complications in black preterm infants.

Adolescent↗

PubMed1993

Paternity patterns and risk of preeclampsia in the last pregnancy in multiparae.

Few authors have published investigations regarding a possible association between preeclampsia and changing paternity. This study employs an epidemiological approach to explore the relationship between severe preeclampsia and changes in paternity patterns among multigravidae in a Caribbean community (Guadeloupe, French West Indies). Multiparae who were diagnosed with preeclampsia or eclampsia with fetal complications (transfer of their infants in the Neonatal Department) and controls were examined (134 mothers' interviews). Information concerning paternity for the index and previous pregnancies was collected from three groups: women with pregnancy-induced hypertension (PIH); women with chronic hypertension (CH); and a control group consisting of women without hypertension during pregnancy. In 21/34 (61.7%) of PIH mothers, the father of the current pregnancy was different than that of the former, compared to 4/40 (10%) among CH and 10/60 (16.6%) in the controls (P < 0.0001). Moreover, considering three and four consecutive pregnancies, there was a significant trend (P < 0.005 and P < 0.02) for an increase in PIH with having a different father in each successive pregnancy. Patterns of changing paternity were significantly correlated with pregnancy-induced hypertension in multiparae but not with chronic hypertension and controls.

Adult↗

PubMed1993

Geographic patterns of low birth weight in Hawaii.

This study examines areal variations in low birth weight, using the census tract as the unit of analysis. Reports from the 1980 U.S. census were used to develop summary indicators of environmental and socio-economic conditions, including poverty, employment, education and crowding, for 155 census tracts in the state of Hawaii. Maternal socio-demographic, prenatal care utilization, and medical risk indicators and low birth weight percentages for resident, single live births were extracted from the Hawaii 1979-1987 vital record live birth files and aggregated by census tract. Multiple regression analysis was used to develop a model that predicted 61% of the variation among census tracts in the percentage of low birth weight. Patterns of low birth weight were primarily associated with ethnic patterns of maternal residence and single marital status. There was no association between inadequate prenatal care and low birth weight at the census tract level.

Adolescent↗

PubMed1993

Multiethnic variations in the pregnancy outcomes of military dependents.

OBJECTIVES: We examined the pregnancy outcomes of three ethnic groups: African-American Blacks, non-Hispanic Whites, and Filipinos. In an attempt to reduce ethnic dissimilarities in parental employment and access to health care, this investigation compared the single-live-birth outcomes of married, adult women who resided in the state of Hawaii and who indicated that their spouse was on active-duty status in the US military. METHODS: The data for this study were obtained from the 1979-1989 Hawaii vital-record file that provides linked live birth-infant death information. Multiple logistic regression was used to calculate odds ratios for the independent effects of maternal factors on low birthweight and neonatal mortality. RESULTS: Significant differences in maternal age, maternal education, paternal education, parity, hospital of delivery, and use of prenatal care were observed among the ethnic groups. The results of a logistic regression analysis of low birthweight indicated significantly higher risks for Filipinos and Blacks compared with Whites. For very low birthweight, only an increased risk for Blacks was observed. No ethnic differences in neonatal mortality were found. CONCLUSIONS: This investigation revealed more comparable infant mortality experiences among the ethnic groups in spite of persistent birthweight differences.

Adult↗

PubMed1992

Validity of postnatal assessments of gestational age: a comparison of the method of Ballard et al. and early ultrasonography.

This study investigates the accuracy of the postnatal gestational age assessment method of Ballard et al. to predict very preterm, preterm, term, postterm, and small-for-gestational-age infants, with gestational age by early ultrasonography used as the gold standard. Sensitivity, specificity, and predictive value were examined for each gestational age category, with 4193 single live births occurring during the period from 1982 through 1989 with an ultrasonographic examination done by 20 weeks' gestation and a postnatal assessment at 28 to 44 weeks. These data indicate that the postnatal assessment overestimated the gestational age of preterm births, resulting in an underestimation of very preterm and preterm percentages. Nearly three fourths of the postterm births by ultrasonography were misclassified by the method of Ballard et al. because of underestimation of postterm gestational ages. These data indicate that, for research purposes, appreciable misclassification of preterm, postterm, and small-for-gestational-age infants will occur if gestational age is determined by the technique of Ballard et al.

Evaluation Studies as Topic↗

PubMed1992

Ethnic variation in postnatal assessments of gestational age: a reappraisal.

While the possibility of an ethnic bias in postnatal assessments of gestational age has been suggested by several investigators, others have reported that postnatal assessments do not provide biased estimates in non-White ethnic groups. In the light of this ongoing controversy, this study examines the validity of the Ballard postnatal assessment of gestational age by ethnicity, using a relatively large hospital data base that allows for the inspection of ethnic variations in the agreement between the Ballard assessment and last menstrual period (LMP). The results indicate that there is a greater over-estimation of the LMP interval by the Ballard method in Blacks compared with Whites and suggest that systematic differences exist by ethnicity of mother in the agreement between the Ballard postnatal assessment and the LMP interval. After taking maternal characteristics and pregnancy complications into account, for a given gestational age interval, Blacks have on average a greater level of maturity as measured by Ballard. One interpretation of these findings is that postnatal assessments may provide biased over-estimates of the LMP gestational age interval in certain ethnic groups. An alternative interpretation of these data is that the gestational age interval based on LMP is not a valid indicator of fetal maturity, readiness for birth and infant risk status across all ethnic groups.

Bias↗

PubMed1992

Using gross motor milestones to identify very preterm infants at risk for cerebral palsy.

The authors evaluated the efficacy of 10 gross motor milestones to screen for cerebral palsy in 173 high-risk, very preterm infants (less than or equal to 32 weeks gestation) followed for 18 to 24 months. Correcting for preterm birth and using population norms led to a better improvement in specificity and positive predictive values; race-specific norms did not contribute significantly. Incorporating a history of milestone attainment into the routine during sequential office visits will help health-care providers to monitor the development of high-risk infants.

Cerebral Palsy↗

PubMed1992

Validity of postnatal assessments of gestational age in low birthweight infants from a Caribbean community.

The Dubowitz assessment of gestational maturity was compared with the best obstetric estimate of gestational age based on date of last menstrual period (LMP) or ultrasonography performed early in the pregnancy or both. This study involved 384 low birthweight infants admitted to the neonatal tertiary center in Guadeloupe, French West Indies, during the period 1986 through 1988. The Dubowitz assessment exceeded the best obstetric estimation by an average of nearly 5 days. This overestimation by the Dubowitz method was observed at every gestational age and was greatest at gestational ages of less than 35 weeks. The physical characteristics of the postnatal assessment were in closer agreement with the best obstetric estimate than the neurological characteristics. These findings concur with other investigations that indicate that the Dubowitz postnatal assessment of gestational age overestimates the gestational age interval from date of LMP in low birthweight and preterm infants.

Evaluation Studies as Topic↗

PubMed1991

Birth weights of infants of black and white mothers without pregnancy complications.

An analysis of 10,159 normal spontaneous vaginal deliveries was performed to examine racial differences in mean birth weight of infants whose mothers were without antepartum or intrapartum medical complications of pregnancy. The study was limited to black and white infants of low-income mothers who were inborn, singleton, and weighed greater than or equal to 500 gm at birth. High-risk maternal transfer patients and patients with hypertension, toxemia, bacteriuria, pyelonephritis, renal failure, diabetes, anemia, polyhydramnios, oligohydramnios, prolapsed cord, vaginal bleeding, placenta previa, abruptio placentae, prolonged rupture of membranes, maternal fever on admission, amnionitis, sexually transmitted diseases, or fewer than five prenatal care visits were excluded. When statistically significant differences in demographic characteristics were controlled, black infants had an average birth weight 181 gm less than that of white infants.

Birth Weight↗

PubMed1991

Differences in black and white infant birth weights: the role of maternal demographic factors and medical complications of pregnancy.

In a retrospective study of 18,631 deliveries among women of low income, we examined the association of racial disparities in mean birth weight with population differences in maternal demographic characteristics and antepartum-intrapartum medical complications. The study population consisted of inborn, nonreferred, singleton, low-income patients delivered on the nonprivate service after at least five prenatal care visits. Repeat cesarean sections were not included. The mean birth weight for black infants was 214 g less than that for white infants. Black and white mothers differed significantly in marital status, age, and years of education. Black and white mothers also differed significantly in the incidence of chronic hypertension, preeclampsia-eclampsia, anemia, amnionitis, fever on admission, and sexually transmitted diseases. In this population, controlling for maternal demographic characteristics and medical complications of pregnancy produced a predicted mean birth weight for black infants that was 100 g less than that for white infants (53% of the observed racial difference in mean birth weight).

Adult↗