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Biomedical subjects

G Quatrehomme

Publications and source records attributed to G Quatrehomme.

At least 19 recordsLinked to original sources
PubMed2003

Acute fatal poisoning with cyamemazine.

A case of fatal poisoning with cyamemazine is presented. The cyamemazine was identified in post-mortem blood using a specific gas chromatographic/mass spectrometry method. The autopsy blood concentration of cyamemazine was 1800 ng/ml. Chronic use of cyamemazine was demonstrated by the presence of the drug in hair. Two other drugs were also detected (bromazepam and trimeprazine). We think that this current blood concentration (1800 ng/ml) is a fatal blood concentration because of the negativity of the other parameters, but careful interpretation of analytical findings are important, the possibility that this death was a consequence of the toxicity of combined drugs could not be excluded. Not many therapeutics and toxic levels were previously reported in overdosage cases in which cyamemazine was involved. We consider that this concentration is only of guidance value for a fatal cyamemazine poisoning.

Anti-Anxiety Agents↗
PubMed2003

Determination of heroin after embalmment.

A 30-year-old male died in Thailand after a scuffle. The corpse was embalmed and repatriated to France where an autopsy was performed. As usual in cases of embalmment, fluids such as blood and urine were unavailable and the toxicological analyses was performed on the bile and the liver. An overdose of heroin was determined as the cause of death. A review of the literature indicates that several drugs can be detected in fluids and tissues that contain formaldehyde. This case demonstrates that in embalmed corpses, toxicological assessment is still possible, e.g. after heroin fatalities.

Adult↗
PubMed2003

Reexamination of a measurement for sexual determination using the supero-inferior femoral neck diameter in a modern European population.

The present study reexamines the accuracy of the supero-inferior femoral neck diameter for the determination of sex using a modern sample of French individuals. In 1998, Seidemann et al. used this univariate method for sex determination with the Hamann-Todd collection. Stojanowski and Seidemann in 1999 tested previous results on a modern sample taken from the University of New Mexico and concluded that the Caucasian male samples exhibited no significant differences between individuals born before and after 1900, but the Caucasian female subgroup did exhibit differences with an increase of the SID in the modern sample. The current study compares the previous results of the supero-inferior femoral neck diameter with a modern sample of elderly French individuals born after 1910. Both sides of the femur were measured. No statistical difference was found between the right and left side (p = 0.31). The results showed a significant difference between the pre-1900 and the modern sample, with an increase in femoral neck diameter in modern populations. The comparison of the SID values between the two modern samples (Mexico and Nice) showed no significant differences in the femoral neck diameter in the two male subgroups (p = 0.05), but the measurements of the SID in the female subgroup did exhibit significant differences with an increase of the neck femoral diameter (p < 0.01) in the modern French population. These results demonstrate an increase in the neck femoral morphology in the elderly European French females samples.

Aged↗
PubMed2001

Odontometrical method useful in determining gender and dental alignment.

Rao et al.'s method of sex determination, which considers the mandibular canine index (MCI) is one giving satisfactory results. However, they did not take occlusion into consideration. The aim of this study, therefore, was to evaluate the effectiveness of this method with respect to tooth alignment. The study population involved the students enrolled in the University of Nice-Sophia Antipolis. Two hundred and ten girls and 214 boys were randomly sampled (1/20). Both tooth sizes and dental arches were measured using a vernier calliper to calculate MCI for both sexes. The results were compared to standard MCI, taking into account tooth alignment.Rao et al.'s method can only be used in the case of correct lower-anterior dental alignment and by using the standard MCI of the local population.

Adult↗
PubMed1999

Medicolegal anthropology in France.

Medicolegal anthropology has a very long history in France. Basic studies on human skeletal remains started as early as the 18th century. The 19th century produced many medical theses and research papers on age, sex, as well as stature estimation. The research proliferated in the first 60 years of the 20th century, much of which is still in use in France and abroad. The later half of the 20th century, however, was dormant in research on human skeletal biology at a time when forensic anthropology was becoming an active field worldwide. In the last decade, medicolegal anthropology took a different perspective, independent of its traditional roots. Research and practice have both been in the professional domain of forensic physicians unlike the situation in many other countries. Population based studies requiring large databases or skeletal collections have diminished considerably. Thus, most research has been on factors of individualization such as trauma, time since death, crime scene investigation, and facial reconstruction. It is suggested that there is a need for cooperation between the forensic physician and anthropologist to further research. This also encourages anthropologists to carry out research and practice that can fulfill the needs of the medicolegal system of the country.

Europe↗
PubMed1999

Characteristics of gunshot wounds in the skull.

The analysis of trauma to the skeleton is an important aspect of forensic case work, but most pathology references devote limited attention to this topic. This paper describes various aspects of gunshot wounds, including entrance and exit patterns, angle and path, range of fire and velocity, and caliber of the bullet, based on observations of a series of known cases. Skeletal remains of 21 victims of gunshot wounds were studied. In most cases, there was documentation of the investigation, autopsy, and victim's identity. Each case was analyzed in terms of wound location, shape, size and exit/entry surface area ratio, beveling, and direction of shooting Skull entry wounds were most often round or oval. Unusual shapes were observed in bones like the mandible and mastoid process, but were also found to be triangular, nearly rectangular or irregular. Tunneling was observed in the mastoid process. The expected internal beveling was obvious in all but one skull. External beveling of an entry wound was only observed in one case (parietal bone). Exit wounds were roughly round, oval, square, and rectangular and were always more irregular than entry wounds. External beveling of exit wounds was observed in most vault bones, but there was none in the orbit, maxilla, greater wing of the sphenoid, temporal, or left occipital bone. Tangential gunshot wounds were seen in a mastoid process, zygomatic process, mandibular ramus and condyle, and occipital condyle. Most of the exit to entry surface area ratios (cm2) varied from 1.4 to 2.0. In four cases the ratio indicated that entrances were larger than exists. In conclusion, understanding of gunshot wound characteristics is an important matter to interpret distance, velocity, direction and sometimes caliber size. Assessment of this nature of gunshot wounds helps reconstruct events surrounding the death.

Adolescent↗
PubMed1998

Anatomical reconstruction of fragments of burned human bones: a necessary means for forensic identification.

The aim of any forensic inquiry concerning accidental or criminal cremations is to identify the victims. This identification depends on an essential approach: a careful collection and ultrasonic cleaning of the fragments and splinters of burned bones, and reconstruction--as far as possible--of bone specimens, which implies that forensic anthropologists are well experienced in the field of burned bones.

Bone and Bones↗
PubMed1998

Gunshot wounds to the skull: comparison of entries and exits.

Specific features usually allow recognition of entrance and exit wounds in bones. Exits are often more irregular, and usually larger than entrances. The aim of this paper is to compare the size of 17 entrance and exit gunshot wounds from a series of 13 forensic cases. The results of this work confirm the usually accepted fact that exit wounds in bones tend to be larger than the entrances resulting from the same shot. In all but one case the exits were larger than the entrances in this study. Though the bullet loses velocity after penetrating, the ballistic behavior (deformation and instability of the projectile) explains this tendency.

Forensic Anthropology↗
PubMed1998

Analysis of beveling in gunshot entrance wounds.

The analysis of skeletal trauma is an important aspect of forensic case work. Yet most major pathology references devote limited attention to this topic. The aim of this paper is to analyze beveling in gunshot entrance wounds, from a series of 27 cases with a total of 39 wounds. Assessment was made by measuring the external and internal cranial dimensions, describing the area of most pronounced beveling, and correlating the directions of the beveling with the trajectory of the bullet. Results indicated that inward beveling was found in 36 of 39 cases, the absence of beveling in four bones, and actual external beveling in one case. The inconsistency in the direction of most pronounced beveling in reference to the direction of shooting leads to the conclusion that this characteristic cannot be used to make a reliable assessment of the direction of fire.

Adolescent↗
PubMed1998

Experimental single controlled study of burned bones: contribution of scanning electron microscopy.

Burned bones were studied using Scanning Electron Microscopy. The samples were cut from a maxillary-mandibular block taken during an autopsy. These fragments were heated in a furnace under controlled temperature conditions for 60 minutes. The temperatures ranged from 150 to 1150 degrees Celsius. The results are as following: (i) there are significant alterations of the bone, more and more obvious as the temperature increases, (ii) it appears to be difficult to establish a precise correlation between the temperature and the scanning electron microscopy patterns.

Aged↗
PubMed1998

Macroscopic and microscopic aspects of incinerated teeth.

Fifty-eight premolars, extracted for orthodontic reasons, were incinerated for one hour in a furnace at temperatures varying from 150 degrees C to 1150 degrees C, increasing at 100 degrees C intervals. Between 150 degrees C and 700 degrees C the teeth changed from light yellow to bluish-white passing through brown. The scanning electron microscope showed that at 150 degrees C cracks appeared in the enamel, increasing in number as the temperature rose. At 450 degrees C the internal surface detached from the dentine and showed the same cracked surface as the exterior. Above 1100 degrees C the enamel fragments had a prismatic structure difficult to identify due to their melted structure. Dentine retained its tubular structure up to 1150 degrees C even when the tubules' diameter decreased at 700 degrees C. The cementum cracked as the temperature increased. Certain cracked areas actually detached at 600 degrees C giving a corroded aspect to the cementum and the residual zones became irregular when the temperature rose and eventually at 1150 degrees C the cementum was no longer identifiable.

Adolescent↗
PubMed1997

Postmortem skeletal lesions.

Postmortem bone alterations are very frequent and can raise the issue of their nature (antemortem, perimortem or postmortem defects). The aim of this work is to study various aspects of defects which were not assessed as perimortem trauma, from a series of 50 defects examined, resulting from 24 forensic cases. This study emphasizes the variability of size, shape and number of postmortem defects. Usually the diagnosis of antemortem defects is helped by a careful examination of some characteristics as the edges of the defects, the areas of discoloration of the edges and of the whole bone. Elsewhere it appears very difficult to know the true nature (antemortem, postmortem, or perimortem alterations) of the bone.

Bone and Bones↗
PubMed1997

Bevelling in exit gunshot wounds in bones.

The analysis of trauma to the skeleton is an important aspect of forensic case work, but most major pathology references devote limited attention to this topic. The aim of this paper is to analyze bevelling in exit gunshot wounds from a series of 14 cases with 17 exit wounds. Assessment of bevelling was made by measuring the endocranial and ectrocranial size of the wound, locating the most pronounced bevelling, and determining if there is a correlation between the direction of bevelling and the direction of shooting. The results indicate outward bevelling of exit wounds in nearly two thirds of cases. No bevelling was observed in the orbits, sphenoid, and in some cases, the occipital and parietal bones. Internal bevelling of exit wounds was not found in this series. Bevelling may be partly understood using a glass model. The inconsistent correlation of the direction of bevelling in exit wounds with the direction of shooting leads to the conclusion that this characteristic cannot be relied upon to determine the direction of fire.

Adult↗
PubMed1997

Contribution of microscopic plant anatomy to postmortem bone dating.

The authors describe a microscopical method of studying plant anatomy for estimating the age of vegetal organs which can help to date bones. This procedure was not based on counting the number of annual rings, as usually, but on demonstrating a completely primary structure without development of secondary formations; this material was considered as a part of a young root system whose development would correspond to about one year. The usefulness and limits of this procedure are discussed.

Adult↗
PubMed1997

A fully three-dimensional method for facial reconstruction based on deformable models.

Two facial models corresponding to two deceased subjects have been manually created and the two corresponding skulls have been dissected and skeletonized. These pairs of skull/ facial data have been scanned with a CT scanner, and the computed geometric three-dimensional models of both skulls and facial tissue have been built. One set of skull/facial data will be used as a reference set whereas the second set is used as ground truth for validating our method. After a semi-automatic face-skull registration, we apply an original computing global parametric transformation T that turns the reference skull into the skull to be reconstructed. This algorithm is based upon salient lines of the skull called crest lines: more precisely the crest lines of the first skull are matched to the crest lines of the second skull by an iterative closest point algorithm. Then we apply this algorithm to the reference face to obtain the "unknown" face to be reconstructed. The reliability and difficulties of this original technique are then discussed.

Cephalometry↗
PubMed1996

Identification by frontal sinus pattern in forensic anthropology.

The authors report forensic cases from the literature, as well as two personal homicide cases, of identification through comparison of frontal sinus radiographs. A general discussion about identification using frontal sinus X-rays is presented, pointing out the reliability of the method, in reference to the uniqueness of the frontal sinus in humans, but also some difficulties, especially in reference to the distance, orientation and angle of the X-ray technique.

Forensic Medicine↗
PubMed1996

Facial casting as a method to help identify severely disfigured corpses.

The authors apply a previously reported method for facial casting of severely disfigured corpses, which allowed a three-dimensional cast to be made. This method involved several stages: face restoration, casting by elastomer, then three-dimensional positive image building. This technique seems to be useful in all cases of severe disfiguration of the face, particularly by trauma.

Adult↗