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Biomedical subjects

G Proud

Publications and source records attributed to G Proud.

121 records · Page 7Linked to original sources
PubMed1980

Plasma suppressive activity and kidney graft survival.

Over the past few years many centres have shown that blood transfusions given to potential renal transplant patients are beneficial to subsequent graft survival. Results from this centre have shown that an elevated ability of plasma to suppress lymphocyte reaction to antigen is associated with blood transfusions in chronic renal failure patients. In a prospective study, plasma suppressive activity was measured at the time of transplantation in 49 patients who were followed for between 3 and 15 months. Results showed that patients with a low level of plasma suppressive activity were at risk from early graft loss due to acute rejection. Furthermore, most of the suppressive activity was related to the naturally occurring plasma protein. alpha 2-macroglobulin. This prospective study reports a significant association between low plasma suppressive activity and early kidney graft loss through rejection, and suggests an explanation for the beneficial effects of blood transfusion on graft survival.

Blood Transfusion↗
PubMed1980

A new finding relating to transfusion and renal transplants.

Results in 29 recipients of second renal transplants from cadaver donors show a significantly better graft survival at 1 year of 90% in 10 recipients who had not received blood transfusion before their first transplant compared to 41% in 19 recipients who had been transfused prior to their first transplant (P = 0.025).

Blood Transfusion↗
PubMed1980

Blood transfusion and organ transplantation.

Blood transfusions given to patients before renal transplantation are associated with improved subsequent graft survival. Non-specific lymphocyte inhibitory activity of plasma is demonstrated in those patients who have received blood transfusions. The activity is directed against the patient's own lymphocytes and is mainly associated with the alpha-2 macroglobulin fraction of plasma. In an animal model blood transfusions are associated with improved graft survival, and the timing of the transfusions before transplantation is important. The administration of alpha-2 macroglobulin is also important in prolonging graft survival. The therapeutic implications of these findings in clinical transplantation are discussed.

Animals↗
PubMed1979

Blood transfusion and renal transplantation.

Blood transfusions given to potential renal transplant recipients are beneficial to subsequent graft survival. This study has shown an association graft survival. This study has shown an association between the inhibitory activity of patients' plasma on their own non-specific lymphocyte responses to antigen and the administration of blood transfusions. Most of the inhibitory activity was related to alpha-2 macroglobulin. Alpha-2 macroglobulin was able to prolong the survival of rat cardiac allografts. Immunoregulatory activity related to the alpha globulins of plasma has been described in a wide variety of conditions (i.e. cancer, pregnancy, diabetes) and this study has shown similar activity following blood transfusions.

Animals↗
PubMedDate not supplied

Ophthalmic triage.

Explore the source record for details and available documents.

Emergency Medical Services↗
PubMedDate not supplied

The widening indications for transluminal angioplasty in peripheral vascular disease.

A prospective study of 57 patients undergoing a total of 85 transluminal angioplasties was undertaken to assess the indications for, and the results of the procedure. We found excellent results with angioplasty in the treatment of isolated iliac artery stenoses, femoral stenoses and short femoral artery occlusions, with a low complication rate. This is the group of patients for whom angioplasty has become a widely used treatment. We feel there is a second group of patients who can benefit from transluminal angioplasty. These are the patients with extensive atherosclerosis in the lower limb vessels where surgery is difficult and the risks of anaesthesia often high due to concomitant coronary artery disease. 66% of these patients in our study obtained significant benefit from limited transluminal angioplasty with a low morbidity and zero mortality. We, therefore, conclude that transluminal angioplasty has an important role to play in the management of these patients.

Adult↗