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Biomedical subjects

G Preti

Publications and source records attributed to G Preti.

At least 19 recordsLinked to original sources

Non-oral etiologies of oral malodor and altered chemosensation.

A number of non-oral causes for oral malodor have been discussed. Several well documented etiologies for non-oral malodor include renal failure, cirrhosis of the liver, and diabetes mellitus. Each of these conditions has been examined using analytical instrumentation. In addition there appear to be several other metabolic conditions involving enzymatic and transport anomalies (such as trimethylaminuria) which lead to the systemic production of volatile malodors that manifest themselves as halitosis and/or altered chemoreception. Our studies include patients who have been referred to us after being examined by numerous clinical specialists with no identification or relief from their problem. This is due in part to the intermittent nature of many of these problems as well as an apparent lack of knowledge concerning many of these metabolic problems and their relation to oral symptoms.

Acetoin

A new method for positioning the maxillary anterior arch, orienting the occlusal plane, and determining the vertical dimension of occlusion.

A new method for positioning the maxillary anterior arch, orienting the occlusal plane, and establishing the vertical dimension of occlusion in edentulous patients is described. The procedure uses a newly developed registration pin assembly that is fixed to the maxillary acrylic resin baseplate. The vertical dimension of occlusion is determined by having the patient swallow. This approach eliminates the tedious and time-consuming process of trimming the occlusion wax rims. The accuracy of the new method is currently being evaluated.

Deglutition

Radiologic-prosthetic planning of the surgical phase of the treatment of edentulism by osseointegrated implants: an in vitro study.

An original prosthetic planning involving CT scan is described; it provides the surgeon with a template for use during the surgical phase of osseointegrated implant treatment. The final prosthodontic reconstruction was planned in a preliminary in vitro study. The CT scan provided a three-dimensional study of the underlying bone, to determine the position, angulation, and depth of the fixture to be used. The specially developed "positioner" decreased the possibilities of error in perforating the mandible. A second CT scan verified whether there were errors in positioning the fixtures. The satisfactory results and the predictability of the final rehabilitation led to the adoption of this method in a clinical research program on human patients.

Dental Implantation, Endosseous

Perceptibility of condylar displacement through transcranial radiographs and split-cast technique on dry skull.

The authors compared the limit of perceptibility of transcranial radiographs and of the split-cast technique in detecting differences in condylar position. The study was carried out on two dried human skulls. The results indicated the split-cast method was superior to the radiographic method as it allowed differences in condylar position of 0.2 mm, both in sagittal and frontal plane, to be detected. The limit of perceptibility of transcranial radiographs for position differences in the sagittal plane was 0.6 mm for naked-eye examination and 0.2 mm when using the subtraction method. Differences in condylar position even as large as 0.6 mm in the frontal plane could not clearly be seen by naked-eye examination, and with the subtraction technique only if they were of at least 0.4 mm.

Humans

Fish-odor syndrome presenting as dysosmia.

We describe a patient who had perceived an unpleasant odor or taste for at least 20 years. Several other physicians had unsuccessfully treated her for infections, mucus membrane dryness and inflammation, chronic tonsillitis, and psychiatric disorders. Her workup at the State University of New York Health Science Center at Syracuse Olfactory Referral Center included a thorough history, examinations (including endoscopic studies of her nose, pharynx, and lungs), roentgenograms, taste testing, olfactory testing, and selective anesthesia of her chemosensory areas. The perception occurred only during exhalation, and appeared to be binasal. These findings, together with her morning mucus sample having a strong fishlike odor, prompted us to suspect a metabolic problem. Further testing at the Monell-Jefferson Chemosensory Clinical Research Center, Philadelphia, Pa, confirmed that she had trimethylaminuria. It is important to consider this and other treatable conditions when evaluating individuals with olfactory complaints.

Adult

A graphic evaluation of the intermaxillary relationship before and after therapy with the Michigan splint.

The effect of the Michigan splint was evaluated graphically in a group of 19 patients. Gothic arch tracings were registered before and after a period of therapy of 4 months, and the two tracings were compared photographically. The position of the apex of the Gothic arch was displaced in most patients, while the shape of the arch was more regular in almost all patients. The validity of the use of the Michigan splint was confirmed.

Adolescent

The unreliability of facial measurements in the determination of the vertical dimension of occlusion in edentulous patients.

The aim of this research was to test the reliability of skin markers in the determination of the V.D.O. in edentulous patients during prosthetic rehabilitation. Two resin baseplates were constructed: on the upper one a modified pin of the Central Bearing Point registration device was fixed with impression compound. The height of the pin could be altered by rotating the pin directly in the patient's mouth with a probe. Two lead spheres were inserted on the resin base-plate as bone markers, and two others were fixed to the skin as markers, one above (end of nose) and one below (point of chin) the oral commissure. Five lateral cephalometric radiographs were exposed for each patient, raising the V.D.O. by 1.2 mm on each occasion. Statistical analysis of measurements made on the resulting radiographs showed a very strong correlation between bone markers and pin position, whereas great variation and considerable differences were found between skin markers and bone as well as measurements.

Adult

[Impression method in patients with maxillo-facial loss with reduction of the degree of oral opening].

The article describes a method for obtaining an impression in patients suffering from a loss of maxillo-facial structure with reduced oral aperture. This involves making an individual resin tray, which is then divided in two, with four plugs on the underside for precise re-alignment later. The method suggested facilitates the insertion and removal of the tray. Thus an accurate impression of the perimeter can be obtained without the risk of trauma.

Dental Impression Technique

[Mounting posterior teeth in complete dentures].

The more common techniques for analysing the alveolar ridge in full dentures were examined. Both the linear analysis and the two-dimensional one, proposed by Pound, were described. The ridge-transfer method was found to be three-dimensional, thus allowing the construction of full dentures which are more stable during each phase of mastication.

Alveolar Process

[Electromyographic evaluation of muscular tension in dysfunctional subjects in relation to normal subjects].

Electromyography has been used to analyse the myoelectric activity of the masticatory muscles in 130 dysfunctional patients in comparison with normal subjects. Of the muscles examined, those presenting greater basal tension were also identified. Myoelectric activity proved greater, at postural values, in dysfunctional patients; by contrast, subjects without craniomandibular symptomatology presented normally low initial values. As for the analysis of the muscular group presenting greater tension, analysis of the results did not produce statistically significant percentages pointing to the prevalence of one muscular group over another.

Adolescent

Analysis of lung air from patients with bronchogenic carcinoma and controls using gas chromatography-mass spectrometry.

Volatile metabolites present in expired lung air were collected by odor sampling techniques and analyzed by gas chromatography-mass spectrometry. The study population included controls matched for age and smoking history with patients newly diagnosed with lung carcinoma. Significantly greater concentrations of o-toluidine were found in the lung air of patients with lung carcinoma than either age-matched or younger controls. Aniline was present in half of the patient population but absent in age-matched controls.

Adult

Lateral transcranial radiography of temporomandibular joints. Part II: Image formation studied with computerized tomography.

Two series of radiographs of 15 subjects (30 TMJs overall) were compared in order to evaluate the reliability of OLTP carried out with different techniques: individualization of incidence through radioscopy (OLTP/fluo) or through the submental vertex method (OLTP/sub). Reasons for formation of noninterpretable radiographs (prevalently with OLTP/sub) and for diagnostic errors in judging condyle position were evaluated for each technique through a CT scanning study of the same patients. The reasons for the wide range of constancy of results found in OLTP/fluo are also discussed. Overall the study demonstrated reliability of the OLTP carried out with the technique of individualizing the incidence through fluoroscopy.

Humans

Lateral transcranial radiography of temporomandibular joints. Part I: Validity in skulls and patients.

Left and right TMJs of 10 skulls and 15 patients (50 TMJs) were studied by means of OLTP and tomography to establish optimal condylar position in the glenoid fossae at maximum dental intercuspation. Two OLTP examinations of each joint were made and individualized by submental X ray and by fluoroscopy. A comparison of the recorded data showed fluoroscopy to give the better result. According to this study, OLTP individualized by fluoroscopy may be a useful tool in the determination of condylar position.

Adolescent

Carbon disulfide: a semiochemical mediating socially-induced diet choice in rats.

Gas chromatography/mass spectrometry revealed the presence of both carbon disulfide (CS2) and carbonyl sulfide (COS) on rat breath. Behavioral experiments indicated that rats exposed to an unfamiliar diet moistened with CS2, like rats exposed to an unfamiliar diet placed on the fur of an anesthetized rat, subsequently exhibited enhanced preference for the unfamiliar diet. Rats in experimental groups: (a) interacted for 30 min with a wad of cotton batting powdered with one of two unfamiliar foods (either Diet A or Diet B) and moistened with a dilute, aqueous CS2 solution, (b) ate Diets A and B in succession and finally, (c) were injected with LiCl. In a subsequent choice between Diets A and B, these rats exhibited a preference for whichever of the foods had been present on the cotton batting during (a). Rats in control groups were treated identically to those in experimental groups, except that the diet-coated cotton batting to which they were exposed was moistened with distilled water rather then CS2 solution. Rats in control groups were not affected in their later diet choice by the food present on the cotton batting during (a). These data are consistent with the hypothesis that CS2 is a semiochemical that mediates social influence on diet selection in rats.

Animals

Human axillary secretions influence women's menstrual cycles: the role of donor extract from men.

Menstrual cycle lengths of 29.5 +/- 3 days ("normal cycles") are more frequent in women who have weekly coital activity than in women who do not. In order to investigate potential mechanisms controlling the association between heterosexual activity and menstrual cycle length, and in light of the nonhuman literature suggesting that a chemical signal from males could be involved, menstrual cycle lengths of nulliparous women were evaluated following regular application of axillary extract from donor males. Compared to controls receiving only blank/ethanol applications, women receiving axillary extracts for 12.5 to 14.5 weeks showed the following changes: a reduced incidence in variability of cycle lengths; and a reduced proportion of aberrant length cycles.

Adult