Search PubMed⌕ Search

Biomedical subjects

G Pradal

Publications and source records attributed to G Pradal.

52 records · Page 3Linked to original sources
PubMedDate not supplied

[Ultrastructure of cerebellar hemangioblastoma].

Authors describe the fine structure of the border zone of a cerebellar hemangioblastoma. This electron microscopie study corroborates all the previous optic microscopic results concerning absence of a well delimited bound between hemangioblastoma and bordering cerebellar tissue. Different stages of peculiar cellular degeneration are found, and an attempt for interpretation is given. However these morphologic changes are insufficient to allow further explanation about the histogenesis of hemangioblastomas, which remains unknown.

Adult↗
PubMedDate not supplied

Study of in vitro drug sensitivity on a newly established cell line from a primary bronchial epidermoid carcinoma of human origin (NSCLCN6).

We studied a cell line established from a primary non-small-cell lung cancer (non-SCLC) of human origin and characterized by midly differentiated epidermoid carcinoma, a human karyotype and keratin expression. Doubling time was about 48 h in vitro and 12 days when transplanted into nude mice. In vitro, this cell line was mainly sensitive to dactinomycin and mitotic poisons such as Vinca alkaloids. Most chemotherapeutic drugs proved ineffective. Our findings are comparable to previous results in patients who showed 30% objective response and less than 5% complete response regardless of the therapeutic associations used against non-SCLC. Our line would also seem to provide a good model for studying new potentially antitumor substances.

Aged↗