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Relevance of the pharmacokinetics of non-steroidal anti-inflammatory drugs (NSAIDs) in children.

The pharmacokinetics of the NSAIDs is relevant to therapy in different ways: absorption, protein binding and distribution, metabolism and elimination. The pharmacokinetics of a drug is most relevant to therapy when plasma concentrations of the drug are related to efficacy and/or to side effects. The kinetic parameters then allow one to calculate the optimal dose regimen, i.e. the one maintaining plasma concentrations within the therapeutic range. The pharmacokinetic characteristics of the different NSAIDs relevant to therapy in children are reviewed.

Absorption↗

PubMedDate not supplied

[Methodology of preparing a list of educational objectives: example of application to pharmacology. Groupe Objectifs Pédagogiques de L'Association des Enseignants de Pharmacologie].

Using a structured approach to categorize pharmacological knowledge and a systemic analysis of prescribing practice, we identified the knowledge needed to optimally prescribe and manage treatments with drugs. The approach consisted in finding the branched chains of knowledge beginning with each operation required to solve each problem which arises in prescribing and managing drugs at the most elementary level. This elementary knowledge is then transformed into educational objectives. The next step is to share the educational objectives between basic medical training, continuing medical education and acquisition of therapeutic knowledge. The method could be applied in other medical teaching domains.

Educational Technology↗