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Biomedical subjects

G Poli

Publications and source records attributed to G Poli.

At least 307 records · Page 17Linked to original sources
PubMed1979

Effect of an essential fatty acid deficient diet on dimethylnitrosamine demethylation and derangement of liver polyribosomes induced by this drug.

Cytochrome P-450 content and dimethylnitrosamine demethylase activity were determined in the liver of male rats fed a polyunsaturated fatty acid deficient diet. The damaging activity of dimethylnitrosamine (DMN) on liver polyribosomes of control and treated rats was estimated. The reduction of DMN demethylase activity did not protect against polysome derangement due to DMN. These data are consistent with the hypothesis that metabolic pathways, other than the P-450 dependent one, are involved in the DMN bioactivation.

Animals↗
PubMed1978

Distribution of Bovid herpesvirus 2 in calves inoculated intravenously.

The behavior of Bovid herpesvirus 2 in the skin, lymph nodes, and nervous system of calves injected intravenously with the virus was studied. After a latent phase that lasted up to 40 hours after inoculation, the virus produced a systemic infection which was characterized by primary localization of virus in the skin, lymph nodes, and nervous system. Between postinoculation days 7 and 12, the infection tended to persist in the skin only. The finding of intranuclear inclusions in the pyramidal cells of the cerebral cortex and in the neurons of the superior cervical and stellate ganglia supports the hypothesis that the virus might utilize the structures of the nervous system for its replicative cycle in the calf.

Animals↗
PubMed1978

Virucidal activity of some quaternary ammonium compounds.

Four different quaternary ammonium compounds were tested by microtechniques for evaluating their activity against the type species of six viral groups very frequently involved in human and animal pathology. Three disinfectants showed good activity against five of the representative viruses under test, while the fourth proved less effective. Poliovirus type 1 was found to be completely resistant.

Adenoviridae↗
PubMed1975

Early polyribosomal and lysosomal changes in the liver of rats poisoned with Amanita phalloides or phalloidin.

30 min after poisoning with Amanita phalloides extract or phalloidin, rat liver polyribosomes appear strongly dissociated, and a small increase of free phosphatase activity is evident. A cycloheximide pretreatment prevents the polyribosome dissociation, without protecting against the lysosomal change. This indicates that the polysomal derangement is not due to a hydrolytic breakdown of messenger RNA. Phalloidin, added in vitro either to a liver cell-free system, or to isolated hepatocytes, does not inhibit their amino acid incorporating activity. The polysome dissociation, therefore, is dependent on changes induced by phalloidin when the liver cell is "in situ".

Agaricales↗