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Biomedical subjects

G Plourde

Publications and source records attributed to G Plourde.

46 records · Page 3Linked to original sources
PubMed1989

Decreasing the toxic potential of intravenous regional anaesthesia.

In an attempt to reduce the dose of local anaesthetic agent during intravenous regional anaesthesia (IVRA) of the upper limb, we have used a forearm tourniquet in 12 adult volunteers. The volume of the forearm venous system was predetermined angiographically. We performed IVRA with three solutions of lidocaine (0.25, 0.375, 0.5 per cent) administered in a volume equal to the forearm venous system. Angiographic results indicate that: a forearm tourniquet provides adequate vascular isolation; the volume of the forearm venous system can be correlated with body weight; the progression of the fluid in the venous system follows a pattern that is similar for all patients with the small veins of the distal forearm and proximal hand being filled last. With this technique, lidocaine 0.5 per cent resulted in a dose of 1.5 mg.kg-1 and provided excellent analgesia. Lower concentrations were unsatisfactory. We conclude that the use of a forearm tourniquet allows reduction of the local anaesthetic dose to a non-toxic level and thus increases the safety of IVRA.

Adult↗
PubMed1989

Impact of dietary fat content and fat oxidation on energy intake in humans.

Three studies were performed to assess the effects of a high-fat diet and exercise-induced changes in fat oxidation on energy intake in humans. In the first study the short-term effect of a high-fat diet on spontaneous energy intake was investigated. The second study evaluated the long-term effect of a high-fat diet on adiposity and the third study evaluated the effect of exercise-induced changes in fat oxidation on short-term regulation of energy intake when subjects were consuming a high-fat diet. The results of these studies indicate that a high-fat diet induces a short-term hyperphagia, a high percentage of lipids in the usual diet is associated with a higher adiposity, and exercise may attenuate or amplify the high-fat, diet-induced hyperphagia, depending on the magnitude of the exercise-induced increase in fat oxidation.

Adaptation, Physiological↗
PubMed1987

Determining gastric contents during general anaesthesia: evaluation of two methods.

Two methods used to measure the volume of gastric contents were evaluated in 24 supine anaesthetized adults. Methods compared were: (1) aspiration of stomach contents through a large, vented, multi-orificed gastric tube, and (2) indirect determination by a dye dilution method using polyethylene glycol (PEG) as the marker. The volumes determined by these methods (Vasp and Vpeg respectively) were compared to the total volume (Vtot) present in the stomach, determined by direct inspection of the gastric pouch by the surgeon at the beginning of surgery. The results show that the volume of aspirated gastric fluid, using this type of tube, is a very good estimate of the total volume of gastric residue. The PEG dilution method yields similar results. However, correlation between Vpeg and Vtot was not as close-fitting as the correlation between Vasp and Vtot. PEG dilution is more complicated, time-consuming and offers no advantage over aspiration.

Anesthesia, General↗
PubMed1986

Aspiration pneumonia: assessing the risk of regurgitation in the cat.

Depending on the population characteristics, 12 to 80 per cent of patients undergoing elective surgery exceed the current risk criteria for aspiration pneumonitis (gastric volume greater than or equal to 0.4 ml.kg-1 and pH less than or equal to 2.5), in sharp contrast to the actual incidence of the disorder, estimated at 0.01 per cent. Improved specificity would likely result if the risk of regurgitation was also considered, in addition to the volume and pH criteria. As a first attempt to assess the risk of regurgitation under general anaesthesia, we measured the minimal gastric volume (VR) required to produce regurgitation in cats anaesthetized with ketamine. The mean was 20.8 ml.kg-1 (n = 7, range: 8-41, SD = 7.8). We conclude that the residual gastric volume needed to produce a regurgitation under general anaesthesia is at least 20 times greater than the volume required to produce pulmonary damage by intratracheal injection (0.3 ml.kg-1, assuming a pH of 2.5 or less).

Anesthesia, General↗
PubMed1984

The cardiomyopathy in Friedreich's ataxia: isotopic ventriculography and myocardial imaging with thallium-201.

Myocardial scanning after the intravenous administration of Thallium 201 was used to evaluate regional myocardial perfusion in 14 patients with Friedreich's ataxia. Isotopic ventriculography was also used to assess left ventricular contractility. Myocardial images in patients with Friedreich's ataxia were found to be precociously abnormal irrespective of the degree of neurological impairment or of the severity of myocardial hypertrophy.

Adolescent↗
PubMed1984

Left hemisphere involvement in left spatial neglect from right-sided lesions.

Current views of the unilateral neglect syndrome caused by right-sided focal lesions generally imply that the left hemisphere is lacking in awareness for the left half of the body and surrounding space. Questioning this assumption on the basis of previous split-brain and hemispherectomy observations, we applied lateralized tests for left hemineglect in three subjects with complete forebrain commissurotomy. Results for the left disconnected hemisphere revealed substantial awareness for the left side of the body and also for extrapersonal space, far greater than suggested by the unilateral lesion data. It is inferred that the left hemisphere, functioning independently, possesses the requisite cognitive mechanisms needed to prevent the appearance of the typical neglect syndrome as observed following right-sided lesions. It is proposed that the eventual explanation of this disorder must therefore account for the lack of left hemisphere compensation.

Attention↗
PubMed1977

Presynaptic modulating effects of GABA on depression, facilitation, and posttetanic potentiation of a cholinergic synapse in Aplysia californica.

The effects of gamma-aminobutyric acid (GABA) have been studied on the synaptic depression, frequency facilitation, and posttetanic potentiation (PTP) of a unitary, monosynaptic, and presumably cholinergic excitatory postsynaptic potential (EPSP). This EPSP, produced by minimal stimulation of the right visceropleural connective, was recorded in cell R 15 of Aplysia californica. Perfusion with GABA (10(-4)-10(-3) M) reduces the size of all EPSPs produced by a train of 100 stimuli at 1/s. It also reduced the synaptic depression and PTP, and increases the frequency facilitation seen during the train. GABA does not significantly effect the membrane resistance (mean 102%) but it slightly depolarizes (mean 6 mV) the postsynaptic cell. GABA does not reduce an acetylcholine iontophoretic potential produced on R15. The effects of GABA are reduction when chloride is replaced by acetate but they remain significant. Picrotoxin and bicuculline fail to antagonize GABA. Addition of sodium azide or dinitrophenol does not reduce the action of GABA and even prolongs it. The effects of GABA are attributed to two sites of action: a postsynaptic one, responsible for the small change in potential and partially responsible for the reduction of EPSP size; and a presynaptic one, responsible for a further reduction of EPSP size and the changes of depression, facilitation, and PTP.

Acetylcholine↗
PubMedDate not supplied

Interweaving and overlapping of evoked potentials.

The refractory effect of one stimulus upon the response to a closely following stimulus in a different modality is much less than upon the response to a stimulus in the same modality. It is therefore far more efficient to record responses to stimuli in different modalities concurrently than to record each one separately. We evaluated 2 techniques for concurrent recording. Interweaving involves recording the response to one stimulus in the intervals between recording responses to other stimuli. Overlapping occurs when two or more responses are at times being simultaneously recorded. Interweaving and overlapping reduced the time required to record auditory brain-stem responses, short-latency somatosensory evoked potentials and pattern-reversal visual evoked potentials by a factor of 3 over the time required to record each response separately. Overlapping caused no significant change in the evoked potentials. Depending upon the actual timing schedule, interweaving may distort the evoked potentials if later parts of the response to one stimulus override the evoked potential to a following stimulus. Filtering and randomization of stimulus timing may attenuate the effects of these overriding potentials.

Adult↗