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Biomedical subjects

G Plomteux

Publications and source records attributed to G Plomteux.

At least 55 records · Page 3Linked to original sources
PubMed1977

[Adaptation on the ABA-100 of the optimized method of measurement of serum aspartate aminotransferase activity].

The analytical modifications necessary for adaptation of the SFBC technic for measurement of the activity of TGO method and those obtained by the technic adapted on ABA 100 suggest that the modifications proposed have no influence on the result of the enzyme estimation. The activation of TGO by addition of its coenzyme was assessed using mathematical models uniting the values of TGO recorded with and without pyridoxal phosphate. It has been shown that the parabolic model is more suitable than the linear model to explain the relation between transaminase activity determined without pyridoxal phosphate and that measured in the presence of the coenzyme. Using estimations carried out in 850 blood donors, it was possible to show that the reference interval of TGO lay between 7 and 28 mUI/ml. In man, the value of TGO is statistically higher than in women. On the other hand between 20 and 60 years there does not seem to be any significant difference depending on age.

Adult↗
PubMed1975

[Statistical evaluation of biochemical data by the method of discrimination analysis. Selection of the discriminant biochemical variables. Attempted biochemical discrimination of intrahepatic cholestasis, extrahepatic obstruction and liver cancer].

An original method of statistical treatment of biological data is proposed. It permits satisfactory biochemical classification of 322 patients divided up into 3 groups : intrahepatic cholestasis (235 patients), extrahepatic obstruction (44 patients) and carcinoma of the liver (43 patients). On the basis of 32 tests, it was possible to define discriminating areas permitting satisfactory diagnosis in 95 per cent of published cases. The reduction in the number of tests necessary for diagnosis was considered. The selection technic used was original to the extent that it dose not require, like most methods used today, the determination of better individual discriminators, but the establishment of a better discriminating subunit, obtained from the initial subunit composed of a group of variables. From the 32 parameters contained in the standard liver function tests, a search for a better discriminating subunit consisting of the best four tests, permitted the authors to select a group of 10 tests : bilirubin, alkaline phosphatase, 5-nucleotidase, Thymolturbidity, Cetavlon test, serum albumin, total LDH, TGP (ALAT), OCT, GLDH, of which the discriminating value remains very satisfactory.

Analysis of Variance↗