A probe into the catalytic activity and subunit assembly of glycogen phosphorylase. Desensitization of allosteric control by limited tryptic digestion.
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Adenine Nucleotides↗
Biomedical subjects
G Philip
Publications and source records attributed to G Philip.
Dinitrophenylation of glycogen phosphorylase. I. Preparation and properties of active dinitrophenyl derivatives.
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Animals↗
Purification & physical properties of a goat intestinal esterase.
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Animals↗
Field applications of agglutination and cytoadherence assays with Plasmodium falciparum from Papua New Guinea.
Plasmodium falciparum isolates obtained directly from patients in Papua New Guinea were tested in their first cycle of growth in vitro for adherence to melanoma cells and for susceptibility to agglutination by immune serum. Binding varied among isolates and, in many cases, increased with further rounds of replication under optimal culture conditions. Binding inhibition assays and agglutination assays demonstrated extreme heterogeneity of surface antigens; apparently none of the sera from adult patients recognized all of the variants presented.
Adult↗
Integrated clinical experience with tolerogenic peptides.
More than 2,000 patients have been dosed in the clinical development programs for Allervax Cat and Ragweed products in North America, Europe and Japan. Two peptides derived from Fel d 1 and three peptides derived from Amb a 1 were selected for clinical development following T cell epitope mapping of these major allergens. Clinical activity has been demonstrated in several dose regimens containing 75 and 750 microg of each component peptide given in 4-6 doses over 2-4 weeks. Greater activity has been seen with higher doses. Immediate hypersensitivity to treatment peptides is rarely seen and can be avoided through patient screening. A putative pathway resulting in histamine-mediated but IgE-independent allergic symptoms, similar in nature and severity to natural allergen exposure, has been identified in association with treatment. These manifestations are more pronounced in cat than ragweed allergy and are consistent with the respective diseases. When desired, the symptoms may be ameliorated with administration of H1 blockers prior to symptom appearance. The seasonal rise in allergen-specific IgE is blunted in association with therapy. Antigen-specific antibody levels (IgE and IgG), T cell primary proliferation and immediate skin test sensitivity will be followed in longer-term studies.
Allergens↗
Spindle cell carcinoma of right lower alveolus. A case report.
A case report of spindle cell carcinoma of the right mandibular alveolus is reported, which clinically mimicked a squamous cell carcinoma. Careful histological interpretation is necessary for successful treatment of such tumors. The use of radiation therapy after radical neck dissection is also stressed upon.
Alveolar Process↗