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Biomedical subjects

G Petri

Publications and source records attributed to G Petri.

At least 37 records · Page 2Linked to original sources
PubMed1984

Monitoring of suppressor cell activity in nine renal transplant patients.

Function of Concanavalin A generated suppressor cells was serially tested on lymphocytes stimulated by mitogens, by a pool of test cells different in HLA-ABC and -DR, and by the kidney donor's cells preserved in liquid nitrogen. In six patients whose lymphocytes had strong suppressor cell activity, the kidney had a good function for 17-28 months (up to the time of the survey). In three patients who had practically no suppressor cell activity before and after transplantation, each kidney was rejected within 2-3 months. These observations are in accordance with recent experimental and clinical studies of other authors supporting the importance of suppressor cell activity in transplantation tolerance.

Humans↗
PubMed1983

Mechanism of the A/Ph.MC.S1 tumor graft rejection in syngeneic mice.

A considerable number of normal mice injected with a low dose of A/Ph.MC.S1 syngeneic methylcholanthrene-induced tumor cells showed regression of the tumor after a transient period of growth. The regressor mice eliminated a challenge inoculum in an accelerated fashion. Splenic lymphocytes from such regressor mice inhibited the growth of the same tumor in the local adoptive transfer assay. This capacity required the presence of thymus-derived cells. The regressor animals developed a delayed-type hypersensitivity response against the tumor In vivo and their lymph-node cells produced macrophage migration inhibitory factor in the presence of tumor cells in vitro. The growth of this tumor was facilitated by treating the primary recipients with carrageenan, and the strong tumor-inhibitory capacity of regressors was also depressed by this agent. Early macrophage infiltration of the tumor in regressor mice was demonstrable histochemically, preceding the inhibition of tumor growth. A lymphokine-producing T cell-mediated, macrophage-dependent delayed-type hypersensitivity-like mechanism is proposed to be the dominant mechanism of the resistance in this tumor-host model.

Animals↗
PubMed1983

[Relationship of immunological status to infections complicating surgery of the large intestine].

The patients immuno-activity has a well-known importance for the outcome of postoperative complications. The authors evaluated the immuno-activity of 95 patients before selective, radical colorectal surgery: 1) 40% of the patients were anergic compared to healthy controls. 2) The incidence of wound infections was significantly higher in the anergic groups than in normal or hyperergic ones. 3) 25% and 50% decrease in wound sepsis has been observed in anergic and normal or hyperergic groups respectively after vaccination 7 to 10 days before operation with vaccine made of E. coli, Proteus, Klebsiella and Pseudomonas strains. The difference indicates the lowered immuno-reactivity on anergic patients.

Colectomy↗
PubMed1981

Cellular immune functions after heart operations.

Eight patients were observed by mitogen stimulation and E-rosetting after heart operations with and without cardiopulmonary bypass. The first sample of blood was taken before surgery, the second on the afternoon of the same day and for a week daily examinations were carried out. A depression of mitogen-stimulated lymphocyte transformation was observed, parallel with a simultaneous T cell depression and a general decrease in the total WBC count. The lowest values were found during the first three days after both open and closed heart operations. After open heart surgery it took a longer time until the values had returned to normal. In two other cases the lymphocytes were examined for suppressor activity. The suppressive effect exerted on the response to mitogenic and allogeneic stimulation was not uniform. Suppressor activity was more affected by surgery than the helper effect in these two cases.

Cardiac Surgical Procedures↗
PubMed1980

Cellular immune function in patients with cancer of the upper part of the gastrointestinal tract.

Lymphocytes of 30 patients were examined for cellular immune function one day prior to operation. In 11 patients the tests were repeated six weeks after surgery. In comparison with 26 healthy blood donors the E rosette values were strongly reduced in the patients group. The zymosan-complement rosette counts were significantly lower if percentages were compared, but not significant when they were expressed in absolute numbers. Lymphocyte transformation tests revealed significant differences between the patients and control cases with all three mitogens applied (PHA, ConA, PWM). In the 11 patients with the tests repeated after operation, the effect of autologous plasma on the cultures was also studied. The main tendency was inhibition but in some cases the patients' plasma enhanced the reaction. Killer cell activity by ADCC was significantly lower in patients' than in the healthy donors' lymphocytes in different target-effector cell ratios.

Animals↗
PubMed1979

[Reye's syndrome. Discussion of a clinical case].

A case of Reye's syndrome in an unweaned child aged 5 1/2 months is reported. The boy presented ingravescent neurological symptomatology accompanied by sporadic gastrointestinal signs and by marked renal impairment, with total, or nearly total absence of pathognomonic laboratory data. The diagnosis was confirmed by autopsy.

Fever↗
PubMed1978

Correlation of the in vivo and in vitro activities of antithymocyte sera (ATS) with the immunizing antigen dose.

Rabbits were immunized with 1, 3, 10, 30, 100, 300, or 1,000 x 10(6) murine thymocytes per kg according to the method of Levy and Medawar. Thus, 33 individual and 6 pooled antimouse antihymocyte serum (ATS) preparations were obtained and tested for in vivo immunosuppressive (graft-protective) as well as for in vitro thymocytotoxic activity. It was found that: (1) at least 3 x 10(6) thymocytes/kg were necessary for inducing ATS of appreciable immunosuppressive activity; (2) rabbits immunized with 30 x 10(6) thymocytes/kg supplied sera of the most potent immunosuppressive activity; (3) the increase of the immunizing antigen dose over 30 x 10(6) thymocytes/kg resulted in ATS preparations of decreased immunosuppressive activity; (4) the graft-protective activity of an ATS pool corresponded to the average of the activities of the individual ATS preparations from which the pool had been mixed, i.e., the process of pooling itself did not modify the immunosuppressive activity; and (5) there was a good correlation (r = 0.72, P less than 0.001) between the in vivo immunosuppressive (graft-protective) activity and the in vitro thymocytotoxic titre of ATS preparations. The theoretical and practical significance of these results if discussed.

Animals↗