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Biomedical subjects

G Pepe

Publications and source records attributed to G Pepe.

At least 109 records · Page 6Linked to original sources
PubMed1988

Breast cancer. A review of 144 cases.

From 1970 to 1980 144 cases of breast cancer were diagnosed in this Department. Patient's age varied between 25 and 83 years with an average age of 51.5 years. 49 (42.98%) patients were in fertile age and 65 patients (57.01%) were in menopause. The incidence of cancer increased after 41 years and the maximal incidence was between 51 and 55 years. Married (117; 81.45%) and pluriparous (75; 65.78%) women prevailed. In the pluriparous the average parity was 4, and 35 (30.70%) pluriparous had greater than or equal to 4 siblings. In 38 cases (27.08%) the patient was nulliparous. In 100 cases (69.64%) diagnosis was made without evident cutaneous alteration. Left and right breasts were affected in 73 (50.69%) and 68 cases (48.21%) respectively. Cancer was bilateral in 3 cases (2.08%). The most frequent cancer localization was ESQ (70 cases; 48.61%). 1st stage was diagnosed in 64 cases (44.44%), 2nd stage in 57 cases (39.58%) and 3rd stage in 23 cases (15.97%). The 5 year survival rate after operation was 86.79% (46 cases), 48.97% (24 cases) and 26.31% (5 cases) in patients at 1st, 2nd and 3rd stage respectively. 13, 8 and 4 patients were lost at follow-up.

Adult↗
PubMed1988

Rectal carcinoid tumors. Report of two cases.

Two cases of rectal carcinoid tumors are reported. In the first case the endoscopic diagnosis was intramural rectal neoformation. At histology, rectal carcinoid tumor with infiltration of the muscularis mucosae was diagnosed. Abdominoperineal resection was performed. The patient is still living 3 years following surgery. In the second case, the endoscopic diagnosis was non-adenomatous polyp. Endoscopic polypectomy was performed. At histology, rectal carcinoid tumor was diagnosed. The patient is still living 2 years following surgery.

Carcinoid Tumor↗
PubMed1988

Current aspects of gynecological pathology in postmenopause.

Between 1982 and 1984 330 women in postmenopause for at least one year were admitted to the First Clinic of Obstetrics and Gynecology, Catania University Medical School, Catania, Italy, with a frequency of 10.04% of gynecological admissions. The most frequent pathologies were metrorrhagia (32.72%; 108 cases) from an atrophic endometrium or glandular hyperplasia of the endometrium, vaginoperineal lacerations with cystorectocoele with or without urinary incontinence (10.90%; 36 cases), cancer (11.21%; 37 cases) and ovarian cystoma (11.21%; 37 cases), uterine prolapse (9.30%; 31 cases), and endometrial polyps (9.09%; 30 cases). Uterine fibromyoma (3.93%; 13 cases) and carcinoma of the portio (3.93%; 13 cases) were among the rare pathologies. Uterine pathologies were the most prevalent (68.78%; 227 cases), followed by ovarian (15.15%; 50 cases), pathology of involving the pelvic and perineal containment (10.90%; 36 cases), vulvar pathology (2.72%; 6 cases), and vaginal pathology (1.51%; 5 cases). Malignant neoplastic pathology was reported in 25.45% of cases (84 cases) consisting only of uterine cancer (47.61%; 40 cases) and ovarian cancer (45.23%; 38 cases). In comparison with the study performed by Cetroni in 1952 one notes a net reduction in the frequency of uterine prolapse (by about three times), and a smaller reduction in cancer of the uterine cervix with a slight increase in cervical polyps, endometrial cancer, and above all in metrorrhagia from atrophic endometrium or glandular hyperplasia of the endometrium.

Adult↗
PubMed1987

Rubredoxin from Desulfovibrio gigas. A molecular model of the oxidized form at 1.4 A resolution.

The crystal structure of rubredoxin from the sulfate-reducing bacterium Desulfovibrio gigas has been determined at 1.4 A resolution (1 A = 0.1 nm) by X-ray diffraction methods; starting with a model of the isostructural rubredoxin from Desulfovibrio vulgaris. Refinement of the molecular model has been carried out by restrained least-squares techniques and Fourier series calculations. The present model includes a formyl at the N-terminal end and 121 possible sites for solvent molecules with full or partial occupancy, which corresponds to the modeling of nearly all the solvent medium. The crystallographic R factor against the data with 10 A greater than d greater than 1.4 A with F greater than 2 sig(F), is 0.136; and R = 0.140 when all the data are considered. The estimated average root-mean-square (r.m.s.) error on the positional parameters is about 0.12 A. The overall structural features of this molecule are close to those of the two highly refined rubredoxins from Clostridium pasteurianum and D. vulgaris. Superposition of these two molecules on the rubredoxin from D. gigas shows in both cases an overall r.m.s. deviation of 0.5 A for the atoms in the main-chain and of 0.4 A for the atoms in the side-chains that make up the hydrophobic core. The iron atom is co-ordinated to four cysteine sulfur atoms forming an almost regular tetrahedron, with Fe-SG distances ranging from 2.27 A to 2.31 A and angles varying from 103 degrees to 115 degrees. The intramolecular hydrogen-bonding pattern is quite comparable to those found in other proteins refined at high resolution. All the polar groups are involved in hydrogen bonds: intramolecular, intermolecular or with solvent molecules. The main structural differences from the other rubredoxins are in the nature and the distribution of some of the charged residues over the molecular surface. The possible influence of several structural factors on the intramolecular and intermolecular electron transfer properties such as the NH...SG bonds, the solvent exposure of the redox center, and the aromatic core is discussed. The conservation, during evolution, of a ring of acidic residues in the proximity of the FeSG4 center suggests that this ring may be implicated in the recognition processes between rubredoxins and their functional partners.

Desulfovibrio↗
PubMed1987

Low rectovaginal fistulas.

Twelve patients aged between 25 and 48 years with parity ranging from 2 to 4 were treated for rectovaginal fistula at the First Clinic of Obstetrics and Gynecology, Catania University Medical School, Catania, Italy from 1965 to 1985. In all patients the rectovaginal fistula was in the inferior third of the vagina and of maximum diameter of 5 cm. Therapy consisted of surgical correction in 9 patients with transformation of the fistula into a complete perineal tear cutting the bridge of healthy tissue under the fistula. Follow-up period varying from 2 to 16 years showed no recurrence.

Adult↗
PubMed1987

Ovarian carcinoma in adolescents.

The Authors describe a case of FIGO IA well differentiated mucinous adenocarcinoma of the ovary which was treated by adnexectomy. Six year follow-up showed the patient to be free of pathology.

Adenocarcinoma, Mucinous↗
PubMed1987

Sexual complications after abdominoperineal resection.

The sexual activity was studied in 28 males and 18 females, one year after abdominoperineal resection for low rectal carcinoma, using a questionnaire. Sexual desire, potentia coeundi and ejaculation, capacity for orgasm and sexual satisfaction in the male, and sexual desire, possibility of vaginal coitus, dyspareunia, orgasm capacity and sexual satisfaction in the female were analyzed. Among the female patients (18 cases), sexual desire was judged to be decreased in 77.77% (15 cases) and decreased capacity for orgasm occurred in 5.5% (1 case). Loss of sexual satisfaction and dyspareunia were present in 44.4% (8 cases) and 33.6% (6 cases) respectively. Among the male patients (28 cases), sexual desire decreased in 75% (21 cases), incomplete erection but sufficient for copulation occurred in 17.85% (5 cases), such as retrograde ejaculation in 10.71% (3 cases) and no ejaculation in 7.14% (2 cases) and impotentia coeundi in 25% (7 cases). In couples that reported a satisfying sexual activity, the first coitus occurred 6 months after surgery (range: 4 to 15 months). In no case was there separation of the couple after surgery.

Adult↗
PubMed1987

Conservative surgery of the ovary.

113 patients aged between 16 and 41 underwent conservative surgery of the ovary between 1965 and 1984 in the First Clinic of Obstetrics and Gynecology, Catania University Medical School, Catania, Italy. The frequency of conservative surgery of the ovary was 0.55% of total gynecological admissions. Indications for surgery were sterility due to postinflammatory adherence in 14.15% (16 cases), in 34.51% (39 cases) ovarian polycystosis after failure of medical therapy with ovulation inducers, in 46.92% (53 cases) pelvic tumor, and in 4.42% (5 cases) hemorrhage of the corpus luteum (4 cases) or ovarian pregnancy (1 case). In 53 cases of enucleation of ovarian tumor the most frequent pathology was serous cyst (41.50%; 22 cases), followed by dermoid cysts (33.96%; 18 cases), cyst caused by endometriosis (18.86%; 10 cases). Luteinic cysts were more rare (3.77%; 2 cases), and in only 1 case was there ovarian cystadenoma (1.88%). Postoperative course was febrile in 7.96% (9 cases) of patients. There were no cases of mortality.

Corpus Luteum↗
PubMed1987

Dysfunctional uterine bleeding in adolescents.

Between 1970 and 1984 89 patients under 18 years of age were treated for dysfunctional premenarchal or postmenarchal bleeding. Patients' age varied from 8 to 18 years (average age 12.2 years). 12 cases were of dysfunctional bleeding in menarche and 68 were of menorrhagic or menometorrhagic menstruation after a period of 2 months to 6 years after menarche. Medical therapy was successful in all cases.

Adolescent↗
PubMed1987

Torsion of the adnexa.

The authors report two cases of adnexal torsion. The first case occurred in a 30-year old patient, while the latter was in a woman after induction of ovulation with FSH-LH and hCG. The patient, who had begun a pregnancy was treated with adnexectomy, and delivered at term a normal baby.

Adnexal Diseases↗
PubMed1987

Intravenous 16-phenoxy PGE2 methylsulfonylamide for induction of labor in cases of fetal death.

Labor was induced via intravenous infusion of 16-phenoxy-prostaglandin-E2-methylsulphonylamide in 13 cases of missed abortion and 19 cases of intrauterine fetal death. In all cases Bishop score was less than 4. Delivery occurred within 24 hours in all cases, with a minimal frequency of side effects (six cases of erythema above the incannulated vein and 1 case of diarrhea). The interval between the beginning of the infusion and delivery was 9.42 minutes. Uterine curettage was performed in 9 cases.

Abortion, Missed↗
PubMed1987

Pelvic tumors in patients under 18 years.

Between 1965 and 1985 28 patients aged between 10 and 18 years (average age 16.3 years) were treated for pelvic tumor, with a frequency of 0.13% of gynecological admissions. Ovarian tumor was the most frequent type (21 cases), followed by paraovarian tumor (5 cases), and uterine tumor (2 cases), 21 of pelvic tumor were neoplastic of which 18 benign. Among the ovarian neoplasias the most prevalent was cystadenoma (9 cases), followed by dermoid tumors (7 cases).

Adolescent↗