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Biomedical subjects

G Paxinos

Publications and source records attributed to G Paxinos.

85 records · Page 5Linked to original sources
PubMed1977

5-hydroxytryptamine depletion with para-chlorophenylalanine: effects on eating, drinking, irritability, muricide, and copulation.

Forty-four male rats were tested for eating, drinking, irritability, and copulation before and after intraperitonial para-chlorophenylalanine (PCPA) or control injections. Eleven of these rats were tested for muricide before and after PCPA injections (Group 1), while 18 others were tested only after PCPA injections (Groups 2). Group 1 rats received four 350 mg/kg PCPA injections spaced 6 days apart and showed hyperdipsia, weight loss, and a 24% increase in muricide. Group 2 rats received five daily 100 mg/kg PCPA injections repeated 11 days later and showed hyperdipsia and weight loss; in addition, 78% of them killed mice. Neither group showed significant changes in copulation. At the end of the experiment, t6 rats from Group 2 that were irritable and killed mice were injected intraperitonially with 5-hydroxytryptophan (80 mg/kg). Five of these rats lost their irritability and four stopped killing. The various behavioral changes were not corrleated significantly either with each other or with the degree of 5-hydroxytryptamine depletion. This tentatively suggests that PCPA may produce its effects on behavior by other means in addition to 5-hydroxytryptamine depletion.

Aggression↗
PubMed1975

The septum: neural systems involved in eating, drinking, irritability, nuricide, copulation, and activity in rats.

Eating, drinking, irritability, muricide, and copulation were measured in 45 male rats before and after one of three coronal knife cuts in the septal region or a control operation; in addition, activity was measured postoperatively. (a) Cuts posteroventral to the septum resulted in slight hypophagia, marked hyperdipsia, irritability, asexuality, and decrease in activity. (b) Cuts of the fornix resulted only in slight decrease in activity. (c) Cuts through the anterior septum resulted in irritability, slight hyposexuality, and slight decrease in activity. No significant correlations between the various behavioral effects were found. It was suggested that the neural pathways mediating eating, drinking, irritability, muricide, copulation, and activity are relatively distinct and that neural activity in the septal region probably does not influence behavior in any unitary fashion.

Aggression↗
PubMedDate not supplied

The role of substance P in arterial chemoreflex control of ventilation.

The postulate that Substance P (SP) plays a neurotransmitter-like role in the arterial chemo- and thermoreflex control of ventilation was examined in conscious rabbits. The investigation was based on CNS neurotransmitter criteria and involved morphological studies using a monoclonal SP antibody, and functional experiments which compared within-animal responses to severe arterial hypoxia (PaO2 less than 35 mm Hg) and to intracisternal SP infusions. Experiments were performed in normal rabbits, and in rabbits pretreated at birth with capsaicin. The data support a neurotransmitter-like role for SP in the arterial chemo- and the thermoreflex control of ventilation, and there appear to be SP-dependent collateral chemoreflex pathways which block thermoregulatory panting through an inhibitory interneuron system.

Afferent Pathways↗