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Biomedical subjects

G Pastore

Publications and source records attributed to G Pastore.

At least 235 records · Page 13Linked to original sources
PubMed1984

Interstitial radiotherapy with Ir192 in vulvar cancer.

Radical surgical intervention is not always possible in vulvar tumours, particularly in infiltrating forms of paraurethral locations. In our case-series, the supplementary performance of Curietherapy, particularly with Radium substitutes (Iridium 192) and following the afterloading method, has enabled us not only to obtain long disease-free periods but also, coupled with the "large volume" of External Radiotherapy, to master forms exceeding the surgical action scope.

Brachytherapy↗
PubMed1983

[Evaluation of free and IgG-bound components of e antigen (HBeAg) in acute virus B hepatitis].

Soluble (free) and insoluble (IgG-bound) hepatitis B e antigen (HBeAg) activities in 1,33 M ammonium sulfate solution was evaluated serially in sera from 12 patients with acute type B hepatitis followed up to 60 days. In three cases preclinical sera were available. In patients who showed clinical and biochemical resolution of hepatitis within 60 days, HBeAg free was the prevalent form of circulating HBeAg during the incubation period of disease, then gradually shifting to the IgG-bound form at the onset of jaundice. Finally HBeAg-bound was no longer demonstrable, followed by detection of anti-HBe antibody. On the contrary, in all patients with unresolved hepatitis both HBeAg-free and HBeAg-bound were detected with prevalence of HBeAg-free ratio. These data suggest a striking correlation between synthesis of HBeAg and HBV replication and may indicate that HBeAg-free and IgG-bound ratio reflects the stage and prognosis of acute HBV infection.

Acute Disease↗
PubMed1983

Survival of children with cancer in Torino, Italy.

During 1967-78, cancer was diagnosed in 870 children living in the Province of Torino. Survival until the end of 1978 is reported separately for cases diagnosed in 1967-70, in 1971-74, and in 1975-78. Comparisons between the three series indicate a statistically significant (p less than 0.05) increase in survival rates for children with leukemia and cancer of the central nervous system as well as a nonstatistically significant increase for children with lymphoma (both Hodgkin's and non-Hodgkin's). No consistent changes in time were noticed for neuroblastomas, nephroblastomas, soft tissue sarcomas, and retinoblastomas. Survival rates for both types of lymphomas and for leukemias (at least for cases diagnosed after 1975) were very similar to corresponding population-derived data from the U.S. and other Western countries. Rates for other cancers were relatively poor in the Province of Torino. It is suggested that relatively high care standards are easier to achieve in the case of childhood cancers requiring chemotherapy than in cancers commonly treated through radiotherapy and/or surgery.

Age Factors↗
PubMed1983

Chronic viral hepatitis in thalassemic liver disease. A long-term study in patients with acute hepatitis with nontransfusion-dependent thalassemia minor.

To evaluate the effective role of hepatitis viruses in thalassemic (Th) liver disease, we carried out a long-term study in 42 subjects with nontransfusion-dependent Th minor hospitalized for an episode of acute viral hepatitis. 10 patients had serologic evidence of hepatitis A, 23 of hepatitis B and 9 of hepatitis non-A, non-B. In the follow-up chronic hepatitis was detected histologically in 5/23 patients with hepatitis B and 5/9 with hepatitis non-A, non-B. All hepatitis A patients recovered completely. The prevalence in 7 out of 10 patients with chronic hepatitis of piecemeal necrosis and of inflammatory changes over hepatic siderosis and fibrosis evidenced a determinant role of chronic viral infection in the development of liver damage in these patients. Thus, heterozygous nontransfusion-dependent Th patients seem to have a high risk of developing a chronic inflammatory liver disease especially after an episode of non-A, non-B hepatitis. Therefore, in our geographical area, chronic hepatitis of viral origin should be taken into account, among other pathogenetic factors, in many cases of cryptogenic thalassemic liver disease.

Acute Disease↗
PubMed1983

Association of father's occupation and cancer in children.

Seven epidemiologic studies on the possible association between parental occupations and cancer in childhood are reviewed. Most were based on the hypothesis of an etiologic role of parental occupations, involving exposure to the broad category of "hydrocarbons". The relevant observations were contradictory, possibly because of the vagueness of the definition of the risk factor. Some findings were significant in at least two studies, such as an excess of machinists and mechanics among fathers of children with Wilms' tumor and an excess of occupations with exposure to paints among children with brain cancer. These and other findings should be considered as hypotheses for further studies.

Adolescent↗
PubMed1983

Characterization of the circulating immune complexes in acute and chronic liver diseases.

The composition of immune complexes (IC) found in 28 patients with HBsAg positive and negative acute and chronic hepatitis was analysed. Components were defined in PEG-precipitated material isolated by preparative ultracentrifugation on linear sucrose density gradients and analysed by the Ouchterlony plate technique and by the radioimmunoassay of hepatitis B virus markers. Sedimentation rate ranged from 8 to 19s in the serum of patients with chronic hepatitis, whereas heavier IC (greater than 19s) were present in the active phase of the disease. The participation of hepatitis B virus in acute hepatitis was shown by the presence of its antigens. In contrast, a low incidence of vital components was seen in IC of chronic active hepatitis and liver cirrhosis. Thus, other causes must contribute to the formation of IC in chronic liver disease.

Acute Disease↗
PubMed1982

Effect of peptichemio in nonlocalized neuroblastoma.

PTC, a mixture of oligopeptides of m-L-sarcholysin, acting primarily as an alkylating agent, was utilized as initial therapy following diagnosis in 80 children with nonlocalized neuroblastoma. Of the 67 evaluable patients (21 Stage III, 41 Stage IV and five Stage IV-S), 51 had measurable lesions allowing to evaluate PTC activity; objective tumor responses to the drug were recorded in 45 of these 51 cases (88.2%); 5/5 Stage III, 37/41 Stage IV, 3/5 Stage IV-S. Complete responses were obtained in seven patients (13.7%), partial responses in 32 (62.7%), objective improvement in six (11.8%). Four patients (7.8%) had either no tumor change, or tumor progression. There have been two early drug-related deaths (3.9%). Stage III and IV patients responding to PTC were then treated by irradiation + VCR, followed by cycles of a combination of ADriamycin, vincristine, and cyclophosphamide. Stage IV-S patients received no further therapy. Thirteen of 21 Stage III (61.9%), five of 41 Stage IV (12.2%) and four of five Stage IV-S (80%) are presently alive from 19-48 months (median, 27 months). PTC is an effective agent in advanced neuroblastoma. However, the results of this report do not indicate that its addition to a "standard" treatment, at least in the schedule adopted in this protocol, has improved the final outcome of children with nonlocalized disease.

Adolescent↗
PubMed1982

The outcome of Wilms' tumor in infants. Italy 1970-79.

Thirty-four infants under 1 year of age with Wilms' tumor were diagnosed and treated in 14 Italian pediatric oncology units during 1970-79. The 3-year survival rates decreased with higher group unilateral tumors: 95% in group I Wilms' tumor, 75% in group II and 20% in group III. The survival rates for children with group I and II Wilms' tumor were similar for those who were treated with surgery and chemotherapy and those who also received postoperative radiotherapy. During 1975-79 fewer patients with group I Wilms' tumor received radiotherapy (1 of 11) than during 1970-74 (4 of 6, p less than 0.05). All these children are alive at this writing.

Female↗
PubMed1982

Late effects of treatment of cancer in infancy.

Eighty-six children were diagnosed with cancer in infancy, followed for at lest 5 years, and assessed for late effects of disease and therapy. One child subsequently died from respiratory failure and 3 died from second primary cancers. Another patient survived second primary cancers of the skin. The high frequency of new cancers (4 observed, 0.09 expected) was attributable to host susceptibility factors and treatment effects. Kyphoscoliosis was diagnosed in 44 patients, 40 of whom had received radiotherapy to the spine. Other patients had neurologic deficits, pulmonary fibrosis, hypoplastic breasts, bowel adhesions, thyroid nodules, musculoskeletal defects, and liver fibrosis associated with tumor therapy. Sequelae of cancer were more common after treatment in infancy than in later childhood. Improved treatments and knowledge of natural history can reduce adverse effects of therapy.

Age Factors↗
PubMed1982

[Observations of the thyroid function after treatment of the laryngeal carcinoma with 60Co].

We have examined 16 patients with laryngeal carcinomas who had been submitted to laryngectomy and subsequent 60Co therapy (dose 60-70 Gy, thyroid exposure 50-60 Gy). After an interval of several years, some patients showed alterations of the thyroid function, i.e. a problematic hypothyreosis in two patients and a latent or compensated hypothyreosis in six patients. The latter could be demonstrated by several functional in-vitro tests (T3 saturation, T4, T3-RIA, TSHV, TRH). Especially the TRH test showed significant alterations in four patients. The results obtained from this relatively small number of cases correspond to the descriptions in literature of irradiation damages to the thyroid caused by the treatment of the laryngeal carcinoma. Despite the necessity of further control examinations of a greater number of patients, the results achieved hitherto suggest a prophylactic or substituting hormone treatment during the radiotherapy of the laryngeal carcinoma.

Adult↗