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Biomedical subjects

G Paone

Publications and source records attributed to G Paone.

78 records · Page 5Linked to original sources
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[Experimental assessment of some pharmacodynamic features of ketoprofen lysine. Pain relief activity, antipyretic effects, anti-inflammatory activity, anti-platelet aggregation activity and interference with the biosynthesis of prostaglandins].

An experimental assessment was made of the analgesic, anti-inflammatory and platelet anticlumping activity of ketoprophene lysine, and its effect on body temperature and prostaglandin synthesis. The drug's pharmacodynamics was very similar to that of ketoprophene and its gastric tolerance was better. It was also well tolerated by the dog joint surfaces and cardiovascular apparatus when given i.m. or i.v., even at doses higher than those advised for man, or when infiltrated in ketoreceptor areas.

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An on-line system for delivery of blood cardioplegia.

A simplified system for delivery of cold blood potassium cardioplegia was tested in 12 experimental animals subjected to 180 minutes of aortic cross-clamping. This on-line system utilized blood drawn from the pump oxygenator which was volumetrically combined with a pre-mixed electrolyte solution (9 parts blood: 1 part drug). A separate heat exchanger was employed to deliver the cardioplegic infusate at 10-15 degrees C. Use of this system permits accurate regulation of infusate potassium concentration, pH, injection pressure and flow rate. Less than one minute is required to obtain an unlimited quantity of arrest solution at steady state values for these parameters. The efficacy of this method of delivery of blood cardioplegia was verified by biochemical and functional studies which revealed no significant changes in myocardial ATP, ultrastructure, compliance, or ventricular function after 3 hours of crossclamping. It is concluded that this system offers a safe and more simplified method of delivering blood cardioplegia than heretofore available.

Animals↗