[Visceral leishmaniasis (kala-azar). Report of a case of infantile Mediterranean leishmaniasis].
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Child, Preschool↗
Biomedical subjects
G Pallesen
Publications and source records attributed to G Pallesen.
[Schistosomiasis in Denmark - patho-anatomical diagnosis].
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Adolescent↗
Neoplastic Paneth cells in adenocarcinoma of the urinary bladder: a first case report.
A case of a highly differentiated, primary, nonurachal adenocarcinoma of intestinal type, originating from the urinary bladder mucosa, is reported. The tumor contained Paneth cells as an integrated part, and their identity on the light microscopic level was confirmed by histochemical stains including immunohistochemical stain for muramidase. A gradual change from Paneth cell types to mucous cells was seen. Argentaffin cells and goblet cells appeared in some parts of the tumor but no detectable transitional forms were found. Only a few carcinomas containing malignant Paneth cells have been recorded, and this case is believed to be the first observed in an extraintestinal site.
Adenocarcinoma↗
A clinicopathological study of 13 Danish Cases of Burkitt's lymphoma.
During a 4-year period 24 cases of malignant non-Hodgkin's lymphomas were proposed to be of the Burkitt-type (BL) by at least 1 of 5 pathologists of the lymphoma Registry in Jutland, Denmark. When the histological material was critically reviewed the diagnosis could be maintained in only 13 cases. 9 of the remaining 11 cases were immunoblastic lymphomas (IBL). Immunohistochemical stainings for cytoplasmic Ig-chains revealed generally weak reactions in the cases of BL. A distinct B-zone homing phenomenon first appearing in the lymphocytic mantle zone was observed in several lymph nodes from 2 patients with BL. In the BL-group the correlation between initial clinical stage and survival was satisfactory, the 2-year survival rate being 38% in the total BL-group. The incidence of BL was 2.1% of the malignant non-Hodgkin's lymphomas in the registry.
Adolescent↗
Large-cell T-lymphoma with hypersegmented nuclei.
Clinical, morphological, cytochemical and immunological features in a case of T-lymphoma in a 67-year-old man are presented. Clinically, a predilection for lymph nodes was observed with a subsequent tumour-like spread to the liver, lungs and, to a minor extent, to the bone marrow. The skin, the spleen and the thymus were spared. Morphologically, the neoplastic lymphoid cells were characterized by their large size and particularly by their hypersegmented nuclei with a relatively coarse chromatin and large nucleoli. Cytochemically, a T-cell-like staining pattern in the acid phosphatase and in the acid alpha-naphthyl acetate esterase stains was absent. The neoplastic lymphocytes demonstrated a strong binding with sheep erythrocytes in suspension and in cryostat tissue sections. The morphological features of this lymphoma appear distinct from other non-Hodgkin's lymphomas. The similarities and the differences of our case in relation to some recently described cases of peripheral T-lymphomas comprising large cells with hyperlobated nuclei, are discussed.
Aged↗
Epstein-Barr-virus-induced lymphoproliferative disorder converting to fatal Burkitt-like lymphoma in a boy with interferon-inducible chromosomal defect.
A 6-year-old boy presenting with swelling of cervical and axillary lymph-nodes was diagnosed as having an Epstein-Barr virus infection because of EBV-nuclear-antigen-positive B-lymphocytes in blood and lymph nodes and high antibody titres to EBV antigens. The natural killer activity of blood-lymphocytes was low, and so was the percentage of T-lymphocytes with Fc receptors for IgG (T-gamma cells). Chromosomal studies revealed a defect in the long arms of one of the chromosomes in pair no. 16 (16q22). The defect only appeared after addition of interferon to the lymphocyte cultures and preferentially in T-gamma lymphocytes. The disease progressed despite attempts to restore the patient's immune reactivity by interferon, transfer factor, and blood transfusions. Necropsy showed that the severe hyperplasia of lymph nodes found during life had become a Burkitt-like lymphoma. The possible connection between an interferon-induced chromosomal defect (break at 16q22) and reduced level of natural killer activity, reduced T-gamma lymphocytes, and proliferation of EBV-positive B-lymphocytes is discussed.
Burkitt Lymphoma↗
Histomorphometrical determination of bone marrow cellularity in iliac crest biopsies.
The point-count principle is an exact method of bone marrow quantitation but fairly good correlation was found between quantitated and estimated values of the cellularity in iliac crest biopsies, although the latter values were significantly lower. No intraspecimen variation was found, but the cellularity in the individual biopsies varied considerably from field to field, indicating that quantitation and estimation on small samples obtained by aspiration may be misleading. The correlation between the values from undecalcified and decalcified sections was high, but decalcification of the biopsies resulted in an underestimation of the amount of haemopoietic tissue.
Adolescent↗
Histological and immunopathological studies in a case of chronic Epstein-Barr virus infection terminating in a Burkitt-like lymphoma.
A 6-year-old boy suffered from a severe lymphadenopathy, characterized histologically by a fulminant polyclonal immunoblast proliferation simulating malignant lymphoma with many immunoblasts resembling Reed-Sternberg cells. He had no history of infectious mononucleosis but Epstein-Barr virus (EBV) infection was evident from serological findings, and EBV-associated nuclear antigen (EBNA) was demonstrated in a high percentage of lymphocytes of blood and lymph nodes. An adequate humoral response to EBV ruled out the possibility of an X-linked recessive lymphoproliferative syndrome as the underlying cause of chronic EBV infection. A chromosomal defect in a subpopulation of lymphocytes was induced by interferon and might somehow be associated with a subtle immunodeficiency of our patient. After exacerbation of the disease chemotherapy was included in the treatment but the patient died 9 months after the onset of the disease. At autopsy the lymphoblastic cell proliferation had changed from that of immunoblasts to cells resembling the Burkitt's lymphoma cells. A change of the proliferating cell type was supported by means of cytochemical and immunological cell markers. The presence of EBV in these cells was demonstrated with the EBNA technique. It is concluded that our case may well support the hypothesis, that EBV may induce lymphoma-like polyclonal immunoblast proliferation in immunodeficient individuals, and that occasionally a monoclonal proliferation of the Burkitt's lymphoma type may supervene.
Biopsy↗
[Burkitt's lymphoma. Review and 4 Danish cases].
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Adolescent↗
B-prolymphocytic leukaemia--a mantle zone lymphoma?
A case of prolymphocytic lymphoma/leukaemia (PL) sensu Galton in a 32-year-old man is presented. The leucocyte count was 19.0 x 10(9)/1 at presentation and tartrate resistent acid phosphatase was present in most prolymphocytes. Immunological investigation of prolymphocytes from lymph nodes, spleen and peripheral blood revealed the surface marker phenotype: SmIg + (mu, (delta), lambda), IgG-Fc-receptor +, C3-receptor +. The prolymphocytes from lymph nodes and spleen were C3-receptor + in a high percentage, while only a few were IgG-Fc-receptor +. This proportion was reversed in the blood prolymphocytes. The histology of lymph nodes was unique and strongly suggested a preferential involvement (homing phenomenon) of the mantle zone of the lymphatic follicle. These results may indicate that emission of prolymphocytes from lymph nodes to circulation involves a change of surface receptors. It is finally suggested to consider the diagnosis of not only hairy-cell leukaemia but also PL in the case of tartrate resistent acid phosphatase-positive lymphoma/leukaemia.
Acid Phosphatase↗
Evaluation of smears obtained by cervical scraping and an endocervical swab in the diagnosis of neoplastic disease of the uterine cervix.
A study of the supplementary value of an endocervical swab smear in addition to cervical scraping in the cytological diagnosis of cervical neoplasias is presented. The two sampling techniques were applied to a population with a high prevalence of neoplastic cervical disease. The endocervical swab smear was a useful adjunct in the detection of mild and moderate dysplasia, and a combination of the two sampling methods decreased the false negative rate in the diagnosis of intraepithelial, as well as invasive neoplasia. In the sphere of specific cytological diagnosis cervical scraping was found to be the more accurate method for diagnosing severe dysplasia and carcinoma in situ, while endocervical swab smears were more useful in diagnosing mild and moderate dysplasia. Differences between the results obtained in our study and comparable studies are discussed. It is concluded that the endocervical swab smear is a valuable adjunct to cervical scraping in the diagnosis of malignant cervical disease. It should not, however, be used as the only sampling method as it produces a higher proportion of unsatisfactory smears, and also because the severity of the epithelial lesion is more likely to be underestimated.
Biopsy↗
Marker chromosome 14q+ in non-endemic Burkitt's lymphoma.
The chromosomal aberrations in tumor cells obtained by bone marrow aspiration from a patient with non-endemic Burkitt's lymphoma (BL) are reported. Twenty percent of the cells contained the marker chromosome 14q+ earlier described in endemic Burkitt's tumors. Other marker chromosomes were dound only in mitoses which did not contain the 14q+.
Adolescent↗
Involvement of aberrant p53 expression and human papillomavirus in carcinoma of the head, neck and esophagus.
Biopsies from 34 patients with cancer of the head, neck or esophagus, 2 laryngeal papillomas, and 2 normal tonsils were analysed for human papillomavirus (HPV), Epstein Barr virus (EBV) genomes and mutated or elevated levels of p53. In 4 biopsies p53 was also analysed by DNA sequencing. HPV type 31 was found in one laryngeal cancer with normal p53 and HPV type 16 in two tonsil cancers with aberrant p53 expression. EBV was detected by PCR in 11 biopsies, but in situ hybridisation and immunohistochemistry, did not confirm this finding. Aberrant p53 expression was observed in approximately half of the tumours. These results support the involvement of both aberrant p53 expression and HPV in the aetiology of squamous cell carcinoma of the head and neck.
Base Sequence↗