Biomedical subjects
G Pagel
Publications and source records attributed to G Pagel.
[Remarks on Freud's "Note on the 'Wunderblock'"].
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Effect of guanfacine on vigilance.
1. In 20 patients suffering from mild hypertension (WHO classification I-II) the effect on vigilance was studied under double-blind conditions. Ten patients were given guanfacine 2 mg daily and ten others a placebo preparation. 2. Before the study and following 2 weeks' medication a battery of tests was applied in which the reaction time and attention were subjected to comparative analysis. The variation in blood pressure and heart rate under mental stress conditions was also tested. 3. The study shows a non-significant reduction in blood pressure in the guanfacine group without the parameters of vigilance being affected. Under mental stress, there was no impairment of haemodynamic reactions. 4. It is concluded that guanfacine, at the selected dose of 2 mg daily, has no apparent effect on the vigilance of hypertensive patients.
[Vigilance of patients with chronic renal insufficiency (author's transl)].
Psychological achievement tests were applied to 56 patients with chronic renal insufficiency for measuring the vigilance. The comparison of test parameters showed a significant impairment with progression of renal insufficiency, an improvement under chronic dialysis treatment depending on complications by medical problems and normal values after successfull transplantation. The vigilance was not influenced by dialysis per se. We conclude that the behaviour of reaction speed, attention performances, and mental concentration reflect the autointoxication of central nervous system in chronic renal insufficiency.
Beta-adrenergic blockade in stress protection. Limited effect of metoprolol in psychological stress reaction.
In a model system the influence of mental stress on blood pressure and heart rate was studied in normal persons and in patients with hypertension (WHO grade III). Metoprolol was employed to investigate the preventive effect of beta-adrenergic blockade on the response to stress. In all groups blood pressure increased significantly during mental stress. The effect was not inhibited by metoprolol. The rise in heart rate, however, was depressed by beta-blockade. Reaction time, opticomotor coordination and concentration ability were studied as parameters of vigilance, but no significant difference between the metoprolol and control groups were observed. Thus, metoprolol only influenced the heart rate in mental stress and it did not affect vigilance.