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G P De Rubeis

Publications and source records attributed to G P De Rubeis.

5 recordsLinked to original sources
PubMed2003

Prognostic value of p53 molecular status in high-risk primary breast cancer.

BACKGROUND: Mutations in the p53 gene are the most common genetic alterations in human primary breast carcinoma and these mutations are often associated with worse prognosis and chemo/radioresistance. PATIENTS AND METHODS: The analysis of the p53 gene was performed by fluorescence-assisted mismatch analysis in 13 consecutive high-risk primary breast cancer (HR-BC) patients with 10 or more involved axillary nodes to evaluate its prognostic value. RESULTS: Three p53 mutations (23%) and four allelic variants were detected. After a median follow-up of 52 months the HR-BC disease-free survival (DFS) was 51% and overall survival 79%. All patients harboring a p53 mutation (p53(mut)) relapsed within 10 months of the median DFS while 67% of those showing a wild-type p53 status (p53(wt)) survive disease-free at a median follow-up of 43 months. One p53(mut) patient is still alive while all the p53(wt) patients survive at 56 months median follow-up. Two out of the four p53(wt) relapsing breast cancer patients showed the Arg72Pro allelic variant; one of these died at 75 months. CONCLUSIONS: p53 mutations may help identify a subset of very high risk breast cancer patients (vHR-BC) with worse prognosis.

Breast Neoplasms↗
PubMed1980

[Gastric resection in the treatment of gastroduodenal ulcer. Our experience in 960 operations].

A personal therapeutic approach to ulcers is described. In this connection, a brief reference to the importance of endoscopy in typings is followed by an account of what is regarded as the best form of treatment. It is felt that resection is the operation of choice when surgery is indicated. Results obtained in 960 cases operated over the last 10 years are cited in support of this contention.

Duodenal Ulcer↗
PubMedDate not supplied

[Non-palpable lesions of the breast: retrospective clinical study].

A non-palpable breast lesion (NPBL) is a disease of the mammary gland that cannot be detected during clinical examination but that can be visualized by mammography and/or ultrasonography, either during screening programs or sometimes in asymptomatic women. These small lesions require an adequate diagnostic-therapeutic approach to ensure correct treatment. The aim of the present study was to analyse a series of NPBLs retrospectively in order to define them nosologically and establish an adequate diagnostic-therapeutic work-up for such cases. Ninety-three patients with a total of 99 NPBLs were observed from January 1989 to December 1999. The 99 NPBLs were submitted to ultrasonography and 31 (31.3%) were also submitted to US-guided fine needle aspiration biopsy (FNAB). Later on the diagnostic-therapeutic procedure involved surgical biopsy after radiological centering and, in the case of malignant neoplastic lesions, surgical intervention and adjuvant therapy. Ultrasonography confirmed the presence of NPBL in 45 cases of the 99 detected at mammography (45.4%). Cytological examination of the 31 FNABs yielded the following results: unreliable 19.3%, suspected malignancy 42%, negative for neoplastic cytology 6.5%, positive for carcinoma 32.3%. The histological diagnosis was one of mammary carcinoma in 41 patients (43%). Among the 41 carcinomas there were 8 (19.5%) carcinomas in situ, 24 (58.5%) invasive ductal carcinomas, 8 (19.5%) invasive lobular carcinomas, and 1 (2.5%) medullary carcinoma. In the 32 (80%) patients submitted to lymphadenectomy for 33 invasive carcinomas, 6 patients (18.7%) presented positive lymph nodes (N1). The Authors conclude that NPBLs are an important clinical entity because they may be the expression of a malignant lesion; most NPBLs are diagnosed during screening programs or sometimes in asymptomatic women by means of mammography, which is the only standardised method for their identification. The poor diagnostic capability of non-invasive methods and the potential malignancy of NPBL justify the indication for surgical excisional biopsies; in cases of histological findings of malignancy it is often possible to perform conservative surgery with similar results to radical surgery in terms of survival. When NPBLs turn out to be invasive carcinomas, a concomitant lymphadenectomy is mandatory.

Adult↗
PubMedDate not supplied

[Correlation with mammography and estrogen receptors in breast neoplasms].

A comparative study of 71 patients with unilateral primary breast cancer was performed to verify a possible correlation between the mammographic findings of the cancer and the content of hormonal receptor. The Nielsen & Poulsen, and Wolfe classification were employed. Hormonal receptor content was determined using the Taylor method. The estrogen content was found to be high in type 1, intermediate in 2 and 4, and low in 3 and 5. Statistically significant difference in the estrogen receptor content was found between type 1 and others groups. Using the Wolfe classification, the hormonal content was found to be high in P1. Statistically significant difference was found between N1 and P2; N1 and DY. No relationship was found between histologic cancer type and hormonal receptor content. The Nielsen & Poulsen classification seems to be most simple and reproducible method respect of the Wolfe's parenchymal patterns. Mammographic findings could be used in selecting patients for endocrine therapy where no estrogen-receptor assay is available.

Adult↗