Biomedical subjects
G P Bondareva
Publications and source records attributed to G P Bondareva.
[The effect of theophylline on purine receptor function in bronchial asthma patients].
A study was made of purine receptors (PR) in healthy subjects and bronchial asthma (BA) patients before and after theophylline (TP) treatment. BA patients demonstrated a significant lowering of the binding sites of A2PR and a tendency toward the rise of the number of A1PR on peripheral blood lymphocytes as compared to the healthy subjects. As a result of TP therapy for 3 weeks, the number of A2PR increased in 69% and the number of A1PR fell in 50% of the patients. The efficacy of TP pharmacotherapy depended significantly on the increment of the binding sites of A2PR. The growth of the number of A2PR was recorded in the groups of patients with a beneficial and satisfactory effect of the treatment.
[Pharmacokinetics and evaluation of the effectiveness of theopek, a Soviet form of theophylline, in bronchial asthma].
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[Leukocyte migration inhibition phenomenon in vivo and in vitro in drug allergy].
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[Clinical importance of the in vivo leukocyte migration inhibition test].
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[In vivo study of human chemotaxis].
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[Lomuzol in the treatment of allergic rhinitis].
The response to lomuzol was registered in 37 out of 39 patients with allergic rhinitis given lomuzol. In 16 patients the response was complete, in 14 partial, in 7 satisfactory. In 6 patients of placebo no effect was recorded. The drug proved uneffective in hypertrophy of the turbinate bones.