Search PubMed⌕ Search

Biomedical subjects

G P Blom

Publications and source records attributed to G P Blom.

12 recordsLinked to original sources
PubMed1988

Observer variation in histologic classification of malignant and borderline ovarian tumors.

Eight hundred sixty-nine primary malignant or borderline ovarian tumors reported to the Norwegian Cancer Registry were reviewed. The histologic slides were randomly distributed to six observers and classified according to the World Health Organization classification of ovarian tumors. By rotation of slides, each tumor was successively reviewed by three observers. Each observer was given approximately 40 duplicates of slides he or she had typed before, mixed in with the slides for the third review. A contracted version of the classification with 27 entries was used in the analysis. Mean intraobserver reproducibility was 62% (kappa, 0.53), varying from 50% to 75% (kappa, 0.34 to 0.70) for the individual observers. The mean rate of agreement between two observers was 56% (kappa, 0.46), varying from 46% to 65% for the individual pairs of observers. The rate of full agreement among three observers was 41%. The most common disagreements were between different specific types of carcinoma, between undifferentiated and differentiated carcinoma, between borderline and malignant tumors, between unclassified and classified carcinoma, and between mixed and pure types of carcinoma. Very low reproducibility was obtained for mixed and unclassified carcinoma.

Carcinoma↗
PubMed1988

Histological studies of gubernaculum testis taken during orchiopexies.

Twenty-five gubernacula were removed for histological examination. All were routinely stained and some were additionally stained for elastic fibres and content of hyaluronic acid. The gubernaculum consisted of moderately vascular, fibrofatty tissue with a core of essentially longitudinally oriented collagenous fibres surrounded by mature fatty tissue. No contractile elements were seen in the gubernaculum. It did not differ from subcutaneous fascia concerning content of elastic fibres and hyaluronic acid.

Adipose Tissue↗
PubMed1986

Glioblastoma multiforme in three family members, including a case of true multicentricity.

Three cases of glioblastoma multiforme are described, occurring in two brothers and the sister of their father. One of the cases was found at autopsy to represent true multicentric glioblastoma, with five widely separated lesions affecting both hemispheres. It is postulated that there may be an association between factors responsible for multiple foci of transformation and a familial tendency to develop glioma.

Aged↗
PubMed1985

The relationship between atherosclerosis of the thoracic aorta and renal scarring in an autopsy material.

With the aim of examining the possible association between atherosclerosis of the aorta and renal scarring, an autopsy study comprising 81 men and 43 women was performed. The per cent intimal surface involved with atherosclerosis in the aorta above the renal arteries was determined by morphometry, and the per cent surface profile of the kidney affected by scarring was measured microscopically in a standardized fashion. In addition, the following variables were determined: the age of the patient, diameter of the renal artery ostia, weight of the kidneys, heart weight, presence or absence of signs of sustained myocardial infarction, highest measured systolic blood pressure and the number of macroscopic renal scars. The data were subjected to both simple correlation and multiple regression analyses. In both men and women there was a significant simple correlation between the degree of atherosclerosis in the aorta and the extent of subcapsular microscopic renal scarring. In men, the prime importance of aortic atherosclerosis for microscopic renal scarring was supported in the multiple regression analysis. In women, this analysis showed that age was the determining predictive factor for microscopical renal scarring. The results may be taken to support the hypothesis that micro-embolism from an atherosclerotic aorta may be a cause of microscopic subcapsular scars in the kidneys.

Aged↗
PubMed1984

Carcinoma of the prostate with soft tissue or non-regional lymphatic metastases at the time of diagnosis: a review of 47 cases.

The clinical course of 47 patients with carcinoma of the prostate who at the time of initial presentation had metastases to soft tissue or non-regional lymph nodes was retrospectively reviewed. The response rate to primary hormonal treatment (orchiectomy or oestrogens) and the duration of response were similar to those of 47 other patients presenting with skeletal metastases only. The survival of the patients in the study group was not statistically different from that of patients with skeletal metastases only. The results suggest that patients presenting initially with metastases to non-regional lymph nodes or soft tissue should be treated by the same therapeutic methods as for disseminated prostatic cancer in general (oestrogens or orchiectomy). Slight or no urinary symptoms at the time of initial presentation in spite of a locally advanced tumour was a common finding; 20% of the patients had normal serum prostatic acid phosphatase despite the presence of disseminated disease. Lymph node enlargement in the left supraclavicular fossa was the most common site of non-regional lymphatic spread. Elderly males with metastatic carcinoma in this region should be investigated for the possibility of prostatic cancer.

Adult↗
PubMed1983

[Thymoma].

Explore the source record for details and available documents.

Humans↗
PubMed1983

A study of hepatic protein synthesis, three subcellular enzymes, and liver morphology in chronically ethanol fed rats.

Male Wistar rats were given ethanol chronically (20-30% of the energy as ethanol) in a nutritionally sufficient regimen. Controls received lipid as isoenergetic substitute for ethanol. Treatment lasted for 2 or 8 weeks. Hepatic protein synthesis was measured in fasted rats during a 32 min. continuous infusion of 3H-valine. After 2 weeks of treatment accumulation of hepatic protein was observed in the ethanol group, but there was no change in hepatic protein synthesis or morphology. After 8 weeks the rate of hepatic protein synthesis was decreased by 35% in the ethanol group, but there was no accumulation of protein and a slight accumulation of intracellular lipid droplets. Neither the subcellular distribution of incorporated 3H-valine, nor the activities and distributions of alcohol dehydrogenase and NADPH cytochrome c reductase were changed. Mitochrondrial cytochrome c oxidase activity was decreased in the ethanol group, and cytosolic and microsomal fractions showed higher cytochrome c oxidase activity in this group. Chronic ethanol treatment for 8 weeks had an adverse effect on general protein synthesis as well as on a specific enzyme in the liver in the absence of serious morphologic abnormalities.

Alcoholism↗
PubMed1978

Lymphomatoid granulomatosis of the lung, liver and spleen.

A female patient with lymphomatoid granulomatosis (LYG) involving lung, liver and spleen is described. Our case presented with signs and laboratory data indicating severe hepatic failure. It is not clear if this disorder represents a distinct pathological or clinical entity. In this report the differences between LYG and the two disease groups which it most resembles, Wegener's granulomatosis and malignant lymphoma are discussed.

Diagnosis, Differential↗
PubMedDate not supplied

Absence of processus vaginalis in a stillborn twin with unilateral testicular retention.

A one day old full term twin boy presented with an abdominal left testis and a scrotal right testis both of which had a normal histological appearance. A gubernaculum with normal macroanatomy and histology was found in the left inguinal canal but no processus vaginalis could be detected. Both of his brother's testes were normally descended. It is suggested that the abdominal position of the left testis was caused by a failing gubernacular reaction due to a local hormone insensitivity.

Diseases in Twins↗