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Biomedical subjects

G Osterman

Publications and source records attributed to G Osterman.

23 records · Page 2Linked to original sources
PubMed1982

Evaluation of serial bone X-ray examination in multiple myeloma.

Fifteen patients with multiple myeloma stage III were treated with a combination of cytostatics and plasmapheresis in a sequential trial running for 60 weeks. Thirteen patients showed clinical improvement and ten a reduction of their myeloma protein by at least 50%. Bone X-ray examination was performed every 15 weeks. Progression of bone lesions was seen in one patient, whereas the radiographic picture was unchanged in the others. It is concluded that bone X-ray, although essential in the diagnosis and staging of multiple myeloma, is not suitable for the monitoring of patients during treatment.

Aged↗
PubMed1980

Fiberendoscopic intramural lesion of the oesophagus.

Iatrogenous oesophageal lesions are rare complications since the introduction of fiber instruments. A recent case is presented of an intramural lesion of the oesophagus in a 33-year-old woman subjected to fiberendoscopy. Etiology, diagnostic and therapeutic measures are discussed. When oesophageal disease is suspected and instruments with side optic are to be used it is advisable to check the oesophagus with a forward viewing fiberscope or contrast X-ray first. Even when a slight resistance is noticed on insertion of the instrument, a perforation must be suspected and the patient subjected to diagnostic and therapeutic measures without delay.

Adult↗
PubMedDate not supplied

Left ventricular asynergy score as an indicator of previous myocardial infarction.

Sixty-eight patients with coronary heart disease (CHD) i.e. a history of angina of effort and/or previous 'possible infarction' were examined inter alia with ECG and cinecardioangiography. A system of scoring was designed which allowed a semiquantitative estimate of the left ventricular asynergy from cinecardioangiography--the left ventricular motion score (LVMS). The LVMS was associated with the presence of a previous myocardial infarction (MI), as indicated by the history and ECG findings. The ECG changes specific for a previous MI were associated with high LVMS values and unspecific or absent ECG changes with low LVMS values. Decision thresholds for ECG changes and asynergy in diagnosing a previous MI were evaluated by means of a ROC analysis. The accuracy of ECG in detecting a previous MI was slightly higher when asynergy indicated a 'true MI' than when autopsy result did so in a comparable group. Therefore the accuracy of asynergy (LVMS greater than or equal to 1) in detecting a previous MI or myocardial fibrosis in patients with CHD should be at least comparable with that of autopsy (scar greater than 1 cm).

Adult↗
PubMedDate not supplied

Relationships between coronary artery obstruction, asynergy, presence of collaterals and the ejection fraction of the left ventricle in patients with coronary heart disease.

Cardioangiographic scores of coronary artery obstructions and corresponding myocardial involvement (MCOS), presence of collaterals (CollS), and asynergy of the left ventricular wall (LVMS) as well as the left ventricular ejection fraction (EF) were examined in 67 patients with coronary heart disease. A covariation was found between LVMS, EF, ECG changes, and a history indicating a previous myocardial infarction (MI). In a multiple regression analysis the EF covariated with LVMS but not with MCOS and CollS. LVMS indicated a previous MI with at least the same sensitivity and specificity as EF. MCOS and CollS give additional information. Collaterals as well as a high MCOS in relation to the LVMS indicate obstruction of coronary arteries which subserve 'non-fibrotic' myocardium. A patient with a high MCOS and CollS and a low LVMS should be expected to gain most functional improvement from coronary bypass surgery. The scores MCOS, CollS and LVMS are comparatively easy to determine and give a more diversified picture of the state of the myocardium than the EF alone.

Angiocardiography↗