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Biomedical subjects

G Ortega

Publications and source records attributed to G Ortega.

At least 37 records · Page 2Linked to original sources
PubMed1997

[Intraoperative serum parathyroid hormone measurement in the surgical treatment of hyperparathyroidism].

BACKGROUND: PTH(1-84) short half life permits us to monitor parathyroidectomy efficacy, confirming complete resection after unilateral surgical approach in some cases of primary hyperparathyroidism. Nevertheless, this utility has been tested in controlled clinical trials and there is no agreement regarding the extraction of samples, their processing and interpretation of results. PATIENTS AND METHODS: In 18 consecutive patients operated on for primary or secondary hyperparathyroidism, serum PTH(1-84) concentrations were assessed at different times before, during and after partial (in 11 patients with multiglandular illness) and total resections. RESULTS: Initial PTH(1-84) concentrations very largely in different pre-resection samples, and these variations significantly affect post-resection percentage reduction. Plasmatic clearance of PTH(1-84) after incomplete resection follows a decreasing exponential curve towards new equilibrium concentrations. The difference is significant comparing with concentrations following complete resection only 5 minutes after, but the 95% intervals with a confidence level of 90% of confidence are exclusive only for determinations after 120 minutes. CONCLUSIONS: The decrement of serum PTH(1-84) concentrations to 20% of the preresection levels 120 minutes after an adenomectomy confirms the complete removal of all pathologic parathyroid tissue. A less sharp decrement must be investigated and may justify an early surgical revision.

Biomarkers↗
PubMed1996

[Extrathoracic sarcoidosis with giant splenomegaly and cranial osteolysis].

Isolated extrathoracic sarcoidosis is a rare entity. We present a 25-year old woman with recurrent episodes of fever of unknown origin in the 10 years previously, with a new episode of fever with hepatosplenomegaly, abdominal adenopathies and cranial osteolysis without pulmonary or mediastinal affectation. With the suspicion of linfoproliferative disease we have resected the spleen with a weight of 1500 g. and multiple non caseous granulomata also in the liver and adenopathies. The clinical presentation is compatible with an atypical sarcoidosis without thoracic affectation and with two rare associated clinical manifestation namely giant splenomegaly and sarcoidosis of the skull.

Adult↗
PubMed1995

[Adrenal gland insufficiency associated with primary antiphospholipid syndrome].

A 32 year old man with previously generalized convulsive episodes developed after one acute infectious process multiple venous and arterial thrombosis and an acute adrenal insufficiency probably due to bilateral adrenal hemorrhage. The clinical picture was considered to be a primary antiphospholipid syndrome with positive IgG anticardiolipin antibodies, and was successfully managed with anticoagulants and steroids.

Adrenal Gland Diseases↗
PubMed1994

Cyclosporin A blocks induction of tumor necrosis factor-alpha in human B lymphocytes.

The effects of cyclosporin A (CSP) on tumor necrosis factor-alpha (TNF-alpha) RNA levels and protein production in human B cells and a B cell line were studied. The ability of CSP to block induction of RNA was compared to its inhibition of protein production in response to anti-IgM, phorbol ester (PMA) and platelet-activating factor (PAF). PAF is a phospholipid which has recently been found to activate human B cells. CSP blocks PAF-induced TNF-alpha RNA from the Ramos cell line, as well as inhibiting the enhancement of TNF protein production from both freshly isolated and Ramos B cells. CSP also blocks anti-Ig induced TNF-alpha RNA and protein but does not inhibit PMA-induced TNF-alpha. We conclude that B cells, like T cells, have CSP-independent and CSP-dependent signaling pathways and that PAF signaling is dependent upon a CSP-sensitive factor.

B-Lymphocytes↗