Search PubMed⌕ Search

Biomedical subjects

G Orndahl

Publications and source records attributed to G Orndahl.

At least 19 recordsLinked to original sources
PubMed1996

Otoneurologic and audiologic findings in fibromyalgia.

Patients with fibromyalgia were studied with otoneurological and audiological tests. Altogether 168 patients (141 women) participated. Vertigo/dizziness was reported by 72% of the patients. Sensorineural hearing loss was found in 15% of the cases. Auditory brainstem responses (ABR) and oculomotor tests were applied, and statistical comparisons between patients and controls were performed. Significant differences were found for the absolute latency of wave V and for the I-V and III-V interpeak latencies, indicating brainstem dysfunction. Abnormal ABR recordings were found in 30% of the cases. In the oculomotor study the mean velocity gain for the smooth pursuits and the mean saccadic latency were significantly different between patients and controls. Abnormal saccades were seen in 28% and pathological smooth pursuit eye movements in 58% of the patients. Electronystagmography was pathological in 45% of the cases. The findings indicate that CNS dysfunction frequently occurs in patients with fibromyalgia, although proprioceptive disturbances might also explain some of the abnormalities observed.

Adult↗
PubMed1995

Cerebral dysfunction in fibromyalgia: evidence from regional cerebral blood flow measurements, otoneurological tests and cerebrospinal fluid analysis.

Measurements of regional cerebral blood flow (rCBF), analysis of cerebrospinal fluid, auditory brain stem responses (ABR) and oculomotor tests were performed in 19 patients with fibromyalgia. The results from the rCBF measurements showed a normal flow level with slight but significant focal flow decreases in dorsolateral frontal cortical areas of both hemispheres. The ABR results showed signs of dysfunction at least at the brain stem level and the oculomotor tests showed high frequency of pathology. The cerebrospinal fluid analysis showed discrete changes in the cell differential count. Possible explanations for the involvement of the central nervous system in fibromyalgia are discussed.

Adult↗
PubMed1994

Functional deterioration and selenium-vitamin E treatment in myotonic dystrophy. A placebo-controlled study.

OBJECTIVES: The aim of the investigations was to study the effect of a combined selenium and vitamin E treatment in patients with myotonic dystrophy. DESIGN: A double-blind placebo-controlled trial. SUBJECTS: Twenty-seven patients with myotonic dystrophy divided into an experimental (n = 13) and a control (n = 14) group. INTERVENTIONS: The experimental group was given increasing doses for 4 months up to a maximum of 1.6 mg selenium and 800 mg vitamin E daily and the control group a corresponding number of placebo tablets. The total treatment period was 2 years. MAIN OUTCOME MEASURES: Muscle strength (knee extension, knee flexion, hand-grip), maximal walking speed for 30 m, function in daily activities (disability), well-being and cognitive functioning. RESULTS: Before treatment, muscle strength showed moderately or markedly reduced values as did maximal walking speed. Disability was most markedly demonstrated in instrumental ADL-activities. Spatial ability was reduced in the majority of patients. During the 2-year follow-up period, the hand-grip strength and maximal walking speed decreased in both groups (P < 0.01). The reduction was not significantly different according to an 'intention-to-treat-analysis'. However, there was a significantly larger decline (P < 0.01) in the left-hand grip strength in the control group when all the patients with complete treatment compliance were included. CONCLUSIONS: A useful set of measurements has been developed for following functional deterioration in myotonic dystrophy. No conclusive evidence of beneficial effects of selenium and vitamin E treatment has been produced.

Adult↗
PubMed1988

Muscle function and morphology in myotonic dystrophy.

Patients with myotonic dystrophy classified clinically into function groups were studied. Muscle strength for knee extension and flexion was, with few exceptions, moderately or markedly reduced with successively more severe clinical disability. The reduction in maximal walking speed showed a similar tendency. There was a large percentage of both type I and in relation to normal findings of type II C fibers in biopsies from most patients. The fiber area varied greatly even in the patients in the best function groups, some of whom had large type II fibers. The most common-histopathological changes, found in all function groups, were fiber atrophy with small angular fibers, internal nuclei, splitting, fibrosis and moth-eaten fibers. A high percentage of type I fibers can already be seen in patients with practically no other morphological changes and without significant functional deterioration.

Adult↗
PubMed1987

Eye motility dysfunction in chronic primary fibromyalgia with dysesthesia.

Thirty-six patients with "chronic primary fibromyalgia" combined with dysesthesia were studied using oculomotor tests. The test results were compared with those of a control group consisting of 71 healthy persons. The saccades were found to be abnormal in 42% of the patients studied. The maximum velocity of the saccades was often reduced, while the accuracy was normal. The smooth pursuit eye movements were deranged in 89% of the patients. The velocity gain was reduced and the number of corrective saccades was increased. The results indicate that brain dysfunction, often at the brainstem level, is commonly seen in patients with chronic primary fibromyalgia syndrome combined with dysesthesia.

Adult↗
PubMed1987

Neuroaudiological findings in chronic primary fibromyalgia with dysesthesia.

Thirty-six patients (31 females and 5 males) with "chronic primary fibromyalgia" combined with dysesthesia were studied using neuroaudiological tests. Auditory brainstem response (ABR) was pathological in 11 patients (31%). In six instances the I-V interpeak latency (IPL) was prolonged, in two instances the interaural difference of wave V (IT5) was pathological, and in three instances there was a reduction of the amplitude of wave V. A comparison of the I-V IPLs between the female patient group and a matching control group showed that there was a significant prolongation of this parameter in the patient group. The ABR-findings indicate that a brainstem dysfunction might be present in some patients with fibromyalgia. The results of the impedance audiometric tests were generally normal in the patient group.

Acoustic Impedance Tests↗
PubMed1986

Myotonic dystrophy treated with selenium and vitamin E.

We have previously reported the successful treatment of a patient with myotonic dystrophy with selenium and vitamin E. This paper deals with the treatment of a further five patients with myotonic dystrophy in different stages. All five patients improved subjectively and objectively in two or more respects. All improved their grip strength according to vigorimeter measurements (Martin), two normalized their gait, another two can now sit down on their heels and stand up, one patient can now walk on his toes, one can now get up from lying on the floor without using a chair and two patients have improved their physical capacity. Patients in early stages of the disease improved faster and more markedly than those in late stages. Electromyographical measurements also showed improvements, in that the myotonic discharges had diminished. The daily dose was 4 mg of Na2SeO3 and 600 mg of vitamin E. Serum concentration of selenium increased in all patients at the beginning of the treatment, but stabilized at a level slightly above the normal. No side-effects were observed.

Adult↗
PubMed1983

Selenium therapy of myotonic dystrophy.

A patient with myotonic dystrophy (MD) has been treated for two years with selenium and vitamin E. The serum selenium concentration and other relevant variables were continuously studied. The patient showed a marked subjective and objective improvement with increased muscular strength and regression of pathological electromyographic findings. To our knowledge, this is the first report of successful treatment of MD.

Adult↗
PubMed1980

Spontaneous reversion from long-lasting atrial fibrillation to sinus rhythm.

We have collected 23 cases with atrial fibrillation (AF) of 3-29 years' duration with spontaneous reversion to sinus rhythm (SR). We have also identified 22 similar cases in the literature. Several of our patients spent several years with different atrial arrhythmias before a stable SR was established. Of all the 45 cases, 39 had significant rheumatic mitral valve disease. In the majority of these patients the ECG shows first degree AV block after return to SR and a low-amplitude P-wave--as if the left atrial P component was lacking. There are no signs of left atrial mechanical activity after re-establishment of SR in our mitral valve disease group, as judged from phonocardiograms, apexcardiograms, echocardiograms and left atrial pressure recordings in selected patients. Heart muscle biopsy was obtained from two patients who underwent mitral valve surgery. Left atrial speciments showed almost complete lack of all muscle structures. There is thus electrical, mechanical and histological evidence of left atrial muscle deterioration. It is likely that the electrophysiological factors responsible for initiation and maintenance of AF have disappeared with this deterioration, thereby allowing SR to be re-established. The return of SR might indicate a progress of the heart disease although the patient may benefit from normalization of cardiac rate and regularity. The easy identification of our 23 patients makes us believe that the phenomenon of appearance of late SR is far more common than suggested up to now.

Aged↗
PubMed1975

Adipose tissue cellularity in relation to metabolism in juvenile onset diabetes mellitus.

Adipose tissue cellularity was determined by a microscopic method in 18 men suffering from insulin dependent, juvenile diabetes mellitus for several years. These results were set in relation to the degree of clinical control estimated from the average urinary glucose output or fasting blood glucose during the year preceding the investigation. Furthermore, the results were compared with controls of comparable age and of the same sex. Both young and middleaged diabetic men had smaller fat cells than non-diabetic men. Fat cell size was correlated to the degree of clinical control, small fat cells indicating a poor control. It was suggested that fat cell size might be included as a measure of the long-term metabolic control in patients with insulin dependent diabetes mellitus.

Adipose Tissue↗