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Biomedical subjects

G Orecchia

Publications and source records attributed to G Orecchia.

42 records · Page 3Linked to original sources

Altered cellular response to UV irradiation in a patient affected by premature ageing.

An abnormal response to UV-irradiation was found in a patient affected by precocious senescence. A decreased level of unscheduled DNA synthesis (UDS) was present in 60% of Go lymphocytes and in fibroblasts after the fifth culture passage. Hypersensitivity of lymphocytes to UV-light was indicated also by a decreased rate of DNA synthesis after mitogen stimulation. The results of this study indicate that the defect which determines the premature ageing influences the capacity to repair UV-induced DNA damage.

Adult↗

Treatment of alopecia areata with diphencyprone.

26 patients with alopecia areata were treated topically with diphencyprone. 10 had alopecia universalis, 7 alopecia totalis and 9 had alopecia areata. The treatment lasted from 4 to 14 months. In 13 patients a little response was obtained; only in 1 case it was satisfactory. Factors that appear to influence these results are discussed.

Adolescent↗

Larva currens following systemic steroid therapy in a case of strongyloidiasis.

The authors report a case of larva currens following systemic steroid administration for acute contact eczema. The patient was found affected with subclinical strongyloidiasis. Strongyloides is not very common in Northern Italy; it is occasionally diagnosed from stool samples from patients complaining of persisting itching.

Aged↗

Chronic bullous dermatosis of childhood.

A case of chronic bullous dermatosis of childhood in a 3-year-old boy is described. Immunoflourescence tests were negative and biopsy of the jejunal mucosa showed marked villous atrophy. The dermatosis was brought under control by a combination of diaminodiphenylsulphone and systemic steroids. The relationship with other bullous eruptions of childhood such as dermatitis herpetiformis and bullous pemphigoid is discussed.

Adrenal Cortex Hormones↗

[Cystine in the treatment of vitiligo].

The paper reports the results of a trial to assess the therapeutical use of cystine followed by sun exposure in 31 patients suffering from vitiligo of different durations. An improvement was obtained in some cases but it was not statistically significant (P = 0.115) when compared to repigmentation which occurred in a control group of 28 patients treated with sun therapy alone. Even the best results, obtained in young patients and in macules on the face and upper limbs, were not cosmetically satisfactory. Possible mechanisms of action are discussed and the results are considered in relationship to the different parameters of the disease.

Adolescent↗