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Biomedical subjects

G Ong

Publications and source records attributed to G Ong.

53 records · Page 3Linked to original sources
PubMed1990

Major gynaecological surgery in patients with severe coronary artery disease--the combined approach.

The gynaecologist today is likely to encounter elderly patients with severe coronary heart disease requiring major gynaecological surgery. The successful outcome in 2 such patients with compromised coronary circulation and impaired left ventricular function emphasized the importance of combined care with the cardiologist and the anaesthetist. The insertion of a Swan-Ganz catheter for close perioperative monitoring is vital. The intra-and postoperative problems are discussed.

Aged↗
PubMed1990

The effectiveness of 3 types of dental floss for interdental plaque removal.

The relative effectiveness of waxed dental floss, dental tape and Superfloss as proximal plaque removal aids were compared in 20 subjects. Each subject used each of the three interdental aids for 1 week. The order of use was randomly selected. Interdental plaque scores were recorded at baseline, weeks 1, 2 and 3. At the end of week 3, subjects answered a questionnaire to ascertain their subjective responses to the 3 types of dental floss they had used. The use of all 3 types of dental floss resulted in significant improvement in interproximal plaque scores compared to baseline scores. Improvement in plaque scores, in decreasing order were: dental tape, dental floss and Superfloss. Dental tape was significantly more efficient than Superfloss (p = 0.003). There were no significant differences observed between the effectiveness of dental tape and waxed floss (p = 0.059), and waxed dental floss and Superfloss (p = 0.143). Regardless of the type of dental floss used, patients removed plaque more efficiently from buccal interproximal areas compared to lingual/palatal interproximal areas (p less than 0.001) and from anterior teeth than posterior teeth (p less than 0.001). Subjective responses indicated that 50% of subjects preferred dental tape, 40% waxed dental floss and only 10% preferred Superfloss.

Adolescent↗
PubMed1990

Delivery of periodontal therapy by general practitioners in Singapore.

The objective of this survey was to determine the capacity of general practitioners to deliver periodontal therapy. This study revealed that only 33% of the dentists surveyed routinely carried out periodontal therapy. The remaining 67% selectively or seldom delivered periodontal therapy. Of the variables investigated, the only variable which played a significant role in the delivery of periodontal treatment was the time since graduation of the dentists, all other factors had no significant influence. 35% of practitioners who had graduated less than 5 years ago routinely carried out periodontal treatment, whereas 50% of practitioners who had been in practice for more than 20 years seldom carried out periodontal therapy. The possible reasons for not delivering periodontal treatment more frequently are discussed.

Age Factors↗
PubMed1989

c-myc oncogene expression and clinical outcome in carcinoma of the cervix.

The expression of the c-myc oncogene was studied in paraffin-embedded specimens of cervical biopsies using a monoclonal antibody which binds to the 62,000 Dalton protein encoded by the c-myc gene. A range of cervical cancers from intraepithelial neoplasia to advanced grade IV tumours were studied together with normal cervical biopsies; c-myc status was correlated to clinical progress. There was no correlation seen between the clinical stage of the disease at presentation and c-myc expression. The 15 patients with c-myc negative cervical cancers were shown to have better disease free (mean--95.4 mos) and total survival (mean 118.0--mos) compared to the 16 patients that were c-myc positive 28.4 and 48.4 mos respectively). The pattern of recurrence differed between the two groups with c-myc positive tumours more likely to develop extra pelvic metastatic disease. The c-myc status of cervical cancer offers a prognostic indicator that could be useful in guiding treatment decisions.

Female↗
PubMed1989

Effect of a desensitizing dentifrice on dentinal hypersensitivity.

The objective of this study was to assess the effectiveness of a dentifrice with 2% dibasic sodium citrate in poloxamer 407 in decreasing dentinal hypersensitivity. The test toothpaste was compared with a control toothpaste containing 0.76% sodium monofluorophosphate in a 6-week double-blind clinical trial. A total of 75 hypersensitive teeth were examined in the test group, while 100 hypersensitive teeth were in the control group. Changes in hypersensitivity levels were monitored after 6 weeks, using thermal, chemical and mechanical stimuli. At the end of 6 weeks, the test dentifrice was not significantly more effective than the control in decreasing dentinal hypersensitivity. Of the stimuli used, cold was the most effective in eliciting a hypersensitive response, followed by chemical stimulation and air. Heat and toothbrushing caused the least discomfort.

Adult↗
PubMed1986

Practical clinical application of the Bi-Digital O-Ring Test in the diagnosis, treatment and follow-up of tuberculosis & parasitic infection.

Using the Bi-Digital O-Ring Test in three clinical cases where standard Western diagnostic methods were not satisfactory; successful diagnosis and treatment were made non-invasively, quickly and inexpensively with the Bi-Digital O-Ring Test. The three cases are as follows: Tuberculosis of the urinary tract; Pleural tuberculosis; Possible parasitic infection of the liver.

Acupuncture Therapy↗
PubMed1982

Positive regulation in a eukaryote, a study of the uaY gene of Aspergillus nidulans: I. Characterization of alleles, dominance and complementation studies, and a fine structure map of the uaY--oxpA cluster.

In this paper we characterize genetically a positive eukaryotic regulatory gene: the uaY gene of the ascomycete Aspergillus nidulans. Several steps in the uptake and degradation of purines are under the control of the uaY gene (summarized in Scazzocchio and Gorton 1977). In the present paper 12 uaY-mutations are characterized with respect to their inducibility for adenine deaminase, xanthine dehydrogenase (purine hydroxylase I) and urate oxidase and by the absence of the uric acid-xanthine permease scored in vivo by resistance to 2-thiouric acid. While 10 mutations are uniformly unleaky, two others are almost wild type for the induction of urate oxidase. A fine structure map of the uaY gene shows that the two "leaky" mutations are not clustered. The fine structure mapping unambiguously positions six uaY alleles and provides preliminary but interesting trends regarding the pattern of gene conversion in the uaY gene. The enzyme levels in all uaY-/uaY+ heterozygous diploids are intermediate between the corresponding uaY-/uaY- and uaY+/uaY+ homozygous diploids, suggesting that one functional copy of the uaY gene is able to mediate the complete induction of only one set of structural genes. No complementation was found between any two uaY- alleles. This establishes that the mutations showing either of the phenotypes are alleles in the same gene; it fails to provide evidence for intracistronic complementation. A mutation, oxpA5, causes resistance to the xanthine analogue oxypurinol (4,6-dihydroxypyrazolo-(3, 4-d)-pyrimidine) and partial constitutivity of adenine deaminase, xanthine dehydrogenase (purine hydroxylase I) and urate oxidase. The constitutive phenotype is suppressed by mutations, blocking the synthesis of intracellular inducers. The mutation is recessive and complements fully with the 11 uaY- mutations tested. It maps to the left of all 12 uaY mutations to which it has been crossed. The data indicate that both the resistance and constitutivity arise from one mutational event in a gene, oxpA, different from uaY and possibly adjacent to it. We propose that the oxpA gene codes for a protein involved in limiting the flow of inducers into the cell nucleus. Thus oxpA and uaY constitute a regulatory gene cluster, indicating that uaY is the regulatory gene.

Alleles↗
PubMedDate not supplied

Practical strategies for a plaque-control program.

With many patients the control of dental plaque is accepted as an important factor in the prevention and treatment of periodontal diseases. However, for others, because this aspect of oral hygiene is not yet totally understood or accepted, plaque control programs often prove to be frustrating and too time-consuming for the general practitioner. This article provides some practical strategies to overcome common pitfalls in delivering a plaque-control program.

Dental Plaque↗