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Biomedical subjects

G Offret

Publications and source records attributed to G Offret.

At least 19 recordsLinked to original sources

[Intraocular penetration of collyria].

UNLABELLED: Some ophthalmic solutions activity is localized at the eye's surface: they are used to manage conjunctivitis and keratitis. Some others must penetrate the eye. They are carried through the cornea. There are many factors allowing the penetration into the cornea. These factors will be studied in this paper. Bio-physical and bio-chemical actions are both numerous and complex. IN CONCLUSION: the different corneal tissues have a selective solubility to ophthalmic solution components.

Cornea

[Senile macula and cerebral functions].

Because of similarities in the physiology and histology of the intraocular and the cerebral circulations, a study of cerebral disorders in patients with senile macular choroidal degeneration (S.M.C.D.) was undertaken. Of 26 cases of S.M.C.D. with sufficient follow-up, 7 showed signs of cerebral disfunction. Types of problems most often found were inordinate disturbances of short-term memory, judgement, and social behavior. It appears that S.M.C.D. tends more to be associated with mental involution than with sensory-motor deficits. Various methods of investigating the cerebro-vascular circulation can be helpful in discussing causes of mental involution, including doppler ultrasound, echotomography Xemon 133 inhalation, positron emission tomography, C.T. scanning, and nuclear magnetic resonance scanning. The physiopathology may involve relative cerebral ischemia, modification of neurotransmitters, and free radical formation, as well as immunologic factors. Specific treatment may one day become reality.

Aged

[Tumors and pseudo-tumoral dysplasias of orbital bones].

The authors review and study, especially from the anatomo-pathological aspect, the different tumours and pseudo-tumoural dysplasias of the orbital bones taken from the collection of the Laboratory of Ocular Pathological Anatomy of the Hotel-Dieu in Paris. They demonstrate the particular frequency of osteomas and fibrous dysplasias and discuss the orbital predisposition of giant cell tumours of bone. Finally they underline the existence of vascular bone tumours and aneurysmal cysts.

Aged

[Fuchs' endothelial dystrophy--the appearance of the corneal endothelium under the electron microscope (author's transl)].

Studying the various stages of Fuchs' endothelial dystrophy with transmission and surface electronmicroscopy makes the dystrophic and degenerative changes in the endothelial and Descemet's membrane visible: dystrophic changes by the formation of tuberosities, whose structure is very similar to that Descemet's membrane, and degenerative changes by reduction in the number of endothelial cells through destruction of the intercellular connections and through cell necrosis. The second stage is the reformation of the structure by fibroblastic cells. The dystrophic cells lead to the formation of a fibrillary tissue between the cells and the tuberosity-laden Descemet's membrane, which is different from the primary structure of this tissue. The origin of these cells is unknown.

Corneal Dystrophies, Hereditary