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Biomedical subjects

G Ochs

Publications and source records attributed to G Ochs.

35 records · Page 2Linked to original sources
PubMed1981

A three-state model for inactivation of sodium permeability.

The inactivation of Na+ permeability in single myelinated motor nerve fibres of Rana esculenta was investigated under voltage and current clamp conditions at 20 degrees C in Ringer's solution and under blocked K+ currents. Development of inactivation and its recovery was described by two potential-dependent time constants: The smaller time constant followed the usual bell-shaped function of membrane potential, whereas the larger one was monotone-increasing with more negative potentials. Several three-state models for inactivation were investigated. The experiments could best be approximated by a model with two open and one closed state for inactivation following: open in equilibrium closed in equilibrium open. Rate constants were determined for all transitions shown from the voltage clamp experiments. The action potentials computed by means of the proposed model were in good agreement with those measured, both in Ringer's solution and under blocked K+ current conditions.

Animals↗
PubMed1980

Phenobarbital induces slow recovery from sodium inactivation at the nodal membrane.

Voltage-clamp experiments were performed on single myelinated nerve fibres of Rana esculenta at 20 degrees C in Ringer's solution and in solutions containing phenobarbital-sodium ([PB] less than or equal to 5 mM). The reduction of the sodium current under phenobarbital could be explained by an increase in the resting sodium inactivation; h infinity (E) was shifted towards more negative membrane potentials. The recovery from sodium inactivation proceeded with two time constants. The fast process could be described with the same time constant as in Ringer's solution, whereas the slow process had a time constant approx. 40 times larger. The slow process was also potential-dependent and could be described by 1/(0.025 alpha h + beta h), where alpha h and beta h denoted the rate constants in Ringer's solution. With the measured blockage of sodium channels by phenobarbital, both the shift of h infinity (E) and the slow recovery from sodium inactivation could be explained.

Animals↗
PubMed1980

Influence of Collagenfleece on bone regeneration.

It can be demonstrated that bone regeneration is stimulated by implantation of Collagenfleece a purified, heterologous collagen preparation. Defects were created in rabbit mandibles which were filled with Collagenfleece on the right side, while the defect on the left side served as a control. The progress in bone regeneration was followed by comparative light and electron microscopic investigations. In contrast to the controls, the defects which were treated with Collagenfleece showed quicker ossification.

Animals↗
PubMed1979

[Effect of dissolved heterologous collagen on human platelet aggregation].

Our in vitro experiments showed the positive effect of a solution containing collagen fleece on aggregation in platelet-rich plasma of healthy subjects and of patients with thrombocytic coagulation disturbances. The added collagen directly affects the adhesion and aggregation of the platelets. The platelets then complete the process of primary hemostasis by forming a thrombus and the plasmatic "intrinsic system" is started. These results have already been implemented at the practical level.

Collagen↗