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Biomedical subjects

G Nylander

Publications and source records attributed to G Nylander.

At least 145 records · Page 8Linked to original sources
PubMed1977

Renal revascularization after splenic artery implantation into the kidney. Studies on angiography ex vivo, microangiography and histology in dogs.

Twenty-eight mongrels were subjected to splenic artery implantation into the left kidney for a period of time varying from 7 days to 32 weeks. In 25 of the kidneys a renal artery stenosis was created. Angiography ex vivo, microangiography and histological examination showed that direct implantation of the splenic artery into the renal parenchyma regularly was followed by an initial thrombus formation in the implanted artery and an early recanalization of this thrombus. Newly formed vessels could be demonstrated in the vicinity of the intrarenal portion of the artery already during the second week after implantation. By way of these newly formed vessels three different types of communications were established between the implanted artery and the original intrarenal arteries.

Animals↗
PubMed1977

Earlier and concurrent morbidity of patients with acute lower leg thrombosis.

The morbidity of 143 patients aged 15-55 years suffering from lower leg thrombosis had been analysed and compared with that of a control material. Ninety-two per cent of the patients suffering from thrombosis had earlier undergone some form of medical care at the hospital. The corresponding figure for the control material was 56%. Of the patients, 6% had a malignant disease, 24% were postoperative, 8% had trauma or fracture of the thrombotic leg, 18% had defects in the fibrinolytic system (58% of those in whom the fibrinolytic defence mechanism was studied), 20% were alcoholics or drug addicts, 15% (31% of the females) had used oral contraceptives, 15% had had an earlier thrombosis of the leg, and 8% of the patients had been in bed with some innocuous disease. It was concluded that a thrombosis often arises in patients with a high earlier morbidity and that most often two or more different conditions may predispose the patients to the disease.

Acute Disease↗
PubMed1977

Immediate changes in blood flow and oxygen metabolism of the cirrhotic liver following portacaval shunt operations.

In 15 patients with cirrhosis of the liver, the pressures in a systemic artery, in the inferior vena cava and the portal vein, flows in the portal vein and the hepatic artery, and oxygen content and acid-base balance in the arterial, portal and hepatic venous blood were studied during operation before and after the construction of an end-to-side portacaval shunt. Portal pressure decreased from 23 to 13 millimeters of mercury. Portal flow increased from 660 mililiters per minute to the liver to 1,300 milliliters per minute through the shunt. Hepatic arterial flow increased from 230 to 480 milliliters per minute, but this did not fully compensate for the loss of portal blood flow to the liver. Accordingly, total hepatic blood flow was reduced. There was also a decrease in the oxygen transport to the liver, but in spite of this, there was no change in the oxygen content in the hepatic vein nor any production of acid metabolites. Possible implications of these findings on the preoperative investigation of patients with portal hypertension are discussed.

Adolescent↗
PubMed1977

A critical reappraisal of Dukes' classification.

The aim of this survey has been to stress the need of a uniform classification of tumor spread. This requires a standard procedure for processing the surgical specimens. An international standardization would permit a more objective comparison of the results of treatment and survival of carcinoma of the colon and rectum in different clinics.

Colonic Neoplasms↗
PubMed1976

The phlebographic pattern of acute leg thrombosis within a defined urban population.

The incidence of thrombosis during one year in a defined population of 263 144 city inhabitants has been studied with a new method based upon acute phlebography of all patients with the slightest symptoms of the disease. The roentgenographic pattern of the acute thrombosis has been studied and the size of the individual thrombus has been compared with the duration of the symptoms. The incidence of thrombosis was found to be 0.9 per mille per year. No correlation was found between the size of the thrombus and the duration of the symptoms. The thrombus had its origin in the calf veins in 89% of the patients and its origin in a vein at a higher level in 10% of the patients. In patients with a thrombus confined to the calf veins the contrast medium always entered the deep crural veins. When the calf vein thrombosis had an extension to the popliteal vein or still higher up the contrast medium bypassed the deep crural veins in more than 75% of the patients.

Adult↗
PubMed1976

A percutaneous intra-arterial technique for producing renal artery stenosis.

A technique for creating an intra-arterial renal artery stenosis in the dog by a percutaneous approach is described. The effect of such a stenosis is evaluated with angiography, renal blood flow measurements, arterial blood pressure determinations and kidney histology. It is concluded that the method is applicable in studies on renal artery stenosis with the advantage of producing a progressive stenosis without any exploration of the kidney.

Animals↗
PubMed1975

The effect of estrogen on the vascular endothelium and its possible relation to thrombosis.

The effect of estrogen on the permeability of the endothelium of the aorta has been studied in the rat. The endothelium was subjected to different forms of chemical injury, and its permeability to silver ions was estimated in rats in a control group and in rats after estrogen treatment. In rats subjected to estrogen treatment, the degree of silver penetration through the endothelium was significantly higher than in untreated rats. This was interpreted as an increased vulnerability of the endothelium after estrogen treatment. Thrombosis in females using oral contraceptives often has an aberrant localization. These findings lead to a theory that an endothelial factor may be involved in the pathogenesis of this form of thrombosis.

Animals↗