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Biomedical subjects

G Nyberg

Publications and source records attributed to G Nyberg.

258 records · Page 15Linked to original sources
PubMedDate not supplied

Time as a risk factor in diabetic nephropathy.

Eighteen individuals with IDDM (type I) and diabetic nephropathy in whom the initial glomerular filtration rate (GFR) was reduced but not below 60 ml/min per 1.73 m2 were observed for an average of 3 yr. The rate of further decline of GFR was found to range between -2 and 21 ml/min/yr. The duration of diabetes until the GFR was first found to be reduced varied between 14 and 33 yr and was not correlated to the ensuing rate of decline in GFR (r = -0.13). In 10 individuals who developed uremia 40 yr or more after onset of IDDM, the development of persistent proteinuria was followed by hypertension and increased serum creatinine 2 yr later and by terminal uremia after an average of 8 yr. This is also the normal time span for individuals who develop terminal uremia after shorter duration of diabetes. We conclude that the course of clinical diabetic nephropathy is not more favorable in individuals with late onset of this complication and that there is no point at which a person with diabetes can be considered to be spared from developing diabetic nephropathy.

Adult↗
PubMedDate not supplied

CAPD in patients with autosomal dominant polycystic kidney disease.

OBJECTIVE: To investigate whether there are specific complications to continuous ambulatory peritoneal dialysis (CAPD) in patients with autosomal dominant polycystic kidney disease (ADPKD) due to defects in various wall structures--causing hernia and diverticulitis--and to enlarged kidneys. DESIGN: The clinical experience of CAPD in 26 patients with ADPKD, treated for 11+/-6 months, was studied in retrospect and compared with that of 26 contemporary controls. Medical records were reviewed with respect to survival in this treatment form and any complication. Peritoneal dialysis capacity (PDC), as measured in 21 ADPKD patients and 20 controls, was also evaluated. SETTING: University Hospital. RESULTS: Before initiation of CAPD, enlarged kidneys necessitated nephrectomy in 2 of 26 ADPKD patients; both cases were registered as preparation for transplantation, not for CAPD. Survival in CAPD was similar in ADPKD patients and controls. Hernia was present in 4 ADPKD patients and 2 controls, and required transfer to hemodialysis in 1 patient from each group, temporarily. The incidence of peritonitis was 1 per 20 months in ADPKD patients versus 1 in 27 months in the controls, not significantly different. Peritonitis was caused by colonic bacteria in similar numbers. Residual renal function was 1.9 2.1 mL/min per 1.73 m2 in ADPKD patients versus 1.9+/-1.4 mL/min per 1.73 m2 in the controls. No difference was detected in any of the variables measured by PDC. CONCLUSION: There were no specific problems related to ADPKD.

Actuarial Analysis↗
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Immune deposits in oral mucosa, skin and kidney in patients with systemic lupus erythematosus.

Biopsies were obtained simultaneously from normal oral mucosa, sun-protected and sun-exposed skin in patients with suspected or diagnosed systemic lupus erythematosus, in order to compare the deposition of immunoproteins. In patients with renal involvement a kidney biopsy was also studied. Immunofluorescence findings at the connective tissue-epithelial junction (lupus band test) showed a good correlation between keratinized oral mucosa and sun-protected skin in 18 sets of biopsies while sun-exposed skin frequently showed more immune reactants. No close connection could be found between the deposition of immune reactants in skin/mucosa and kidney. It is concluded that diagnostic use of the lupus band test performed on normal mucosa has the same value as that on sun-protected skin.

Adult↗
PubMedDate not supplied

Multiplanar spinal anatomy: comparison of CT and cryomicrotomy in postmortem specimens.

Good anatomic knowledge is a prerequisite for correct interpretation of computed tomographic (CT) scans. To elucidate the complex CT anatomy of the spine, autopsy specimens from various spinal regions were frozen in situ to preserve the undistorted topographic anatomy. The frozen specimens were examined by CT in axial, sagittal, and coronal planes and sectioned by cryomicrotomy along the scanning planes. Photography of the section surfaces yielded detailed anatomic images that were accurately correlated with the CT scans.

Adult↗