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Biomedical subjects

G Nuzzaci

Publications and source records attributed to G Nuzzaci.

At least 19 recordsLinked to original sources
PubMed1992

Color Doppler imaging in evaluation of optic nerve blood supply in normal and glaucomatous subjects.

The authors evaluate by means of Color Doppler Imaging (CDI) the blood flow in ophthalmic artery, posterior ciliary arteries and central retinal artery in a group of glaucomatous patients. The data obtained in this study show a statistically significant reduction of the mean systolic peak flow velocity in ophthalmic artery in glaucomas in comparison with controls. In Glaucomatous patients with uncontrolled IOP there was a reduction of end-diastolic flow velocities and a rise of resistivity index in ciliary arteries and central retinal artery.

Adult↗
PubMed1992

[Defibrotide vs. calcium heparin in the prevention of deep vein thrombosis in gynecologic oncologic surgery].

Eighty-one patients were submitted to gynaecological malignancy surgery in a randomized study aimed at the evaluation of the efficacy of defibrotide (40 patients) and calcium heparin (41 patients) in perioperative prophylaxis. They were randomly allocated to defibrotide group (400 mg bid im starting one day before surgery and continuing until the 7th postoperative day) or calcium heparin group (5000 IU bid sc starting two hours before surgery and continuing likewise for 7 days). No cases of DVT diagnosed by means of a Doppler CW were observed in either treatment group. Laboratory parameters have shown similar modifications in the two treatment groups. Three cases of bleeding were observed in the calcium heparin group while no cases of bleeding were detected in the defibrotide group. The results obtained suggest that defibrotide is at least as effective as calcium heparin in perioperative DVT prevention and that the former drug has a possibly better tolerability profile, due to a decisively lower tendency to bleeding.

Aged↗
PubMed1989

Pachydermoperiostosis (primary hypertrophic osteoarthropathy): report of a case with evidence of endothelial and connective tissue involvement.

A case of pachydermoperiostosis characterised by the presence of finger clubbing, periostosis, sweating of hands and feet is described. Modifications of capillaroscopic pattern and of arteriovenous anastomoses are reported. The periungual border and finger tip tissue showed diffuse endothelial hyperplasia, hyalinosis, and sclerosis with packing of collagen fibres. Electron microscopy showed hypertrophic and activated endothelia (numerous and hypertrophic Golgi complexes, several Weibel-Palade bodies, vesicles of micropinocytosis, and glycogen particles), the basal membrane thickened and reduplicated, perivasal infiltrate in superficial derma, reticulation and segmentary reduplication of basal membrane in arteriovenous shunt. In the perineural connective tissue numerous Luse bodies (long spacing collagen) were evident. The data indicate that in the early phase of pachydermoperiostosis morphological endothelial and collagen fibre abnormalities are present, though there is a normal peripheral blood flow.

Adult↗
PubMed1989

Sonography of vertebral arteries in De Kleyn's position in subjects and in patients with vertebrobasilar transient ischemic attacks.

Two groups of subjects, matched for age, were studied. The first group consisted of 190 healthy subjects, the second, of 60 patients with vertebrobasilar transient ischemic attacks (TIAs), 22 of whom underwent angiography. After it was ascertained that the findings from continuous-wave (cw) Doppler of carotid and vertebral arteries, performed in the standard position, were normal, the examination was then done in De Kleyn's position, the velocity signal being detected at the mastoidal slopes. The abnormal findings were classified into two groups: "loss of diastolic velocity signal" and "absence of velocity signal." In the control group, changes of flow were detected in 6.31%, whereas in the group of patients abnormal Doppler parameters were detected in 33.33%. None of the patients who were submitted to angiography showed abnormal hemodynamic findings. The authors suggest that the detection of the velocity signal of the vertebral arteries in De Kleyn's position could be of help in revealing conditions that could cause, in time, signs and/or symptoms of vertebrobasilar insufficiency in subjects with possible asymptomatic anomalies of the circle of Willis.

Blood Flow Velocity↗
PubMed1988

Continuous-wave Doppler of vertebral arteries in noninvasive diagnosis and management of vertebro-basilar TIAs.

Continuous-wave Doppler and angiography of the vertebro-basilar system were used in 38 patients with vertebro-basilar transient ischemic attacks. 63 vertebral arteries were studied. Among 47 normal Doppler parameters, 46 were confirmed by angiography. The sonographic diagnostic procedure showed a very high negative predictive value (97.87%), while the positive predictive value was relatively low (56.25%). Data from literature were reviewed. The authors suggest that when Doppler of vertebral arteries is negative, there is a very low probability that a follow-up angiography will reveal pathologic conditions calling for a surgical approach.

Cerebral Angiography↗
PubMed1988

Arteriovenous anastomoses' function and Raynaud's phenomenon.

By intrabrachial artery injections of a bolus of human albumin microspheres labeled with 99mTc in patients with primary or secondary Raynaud's phenomenon (RP) and in a group of healthy volunteers, the authors developed a method of detecting the patency rate of arteriovenous anastomoses (AVA) in the hand, after local heat and cold stimulation, by quantifying the radioactivity of the lungs expressed as a percentage of an intravenously injected radionuclide dose. With strain gauge plethysmography, simultaneous changes in the digital total (DTF) flow were also measured. After exposure of fingers to cold, 25 of 26 subjects had a clear reduction in both DTF and the AVA patency rate (APR) in comparison with the corresponding heat values. The RP patients, in particular, showed a statistically significant reduction in DTF (P less than 0.001) and in APR (P less than 0.001). These results appear to be consistent with the onset of critically reduced patency of the AVA of the hand during the ischemic phase of RP.

Adult↗
PubMed1987

[The duplex scanner].

Explore the source record for details and available documents.

Arterial Occlusive Diseases↗
PubMed1984

A study of the semeiological reliability of dorsalis pedis artery and posterior tibial artery in the diagnosis of lower limb arterial occlusive disease.

Routine diagnosis of suspected occlusive arterial disease of the lower limbs are often based on the pulse absence at the dorsalis pedis artery. However many of these diagnoses are not confirmed after more thorough tests, and this fact arises the problem of the semeiological reliability of the above mentioned artery. Researches carried out by several authors in normal individuals on the dorsalis pedis artery yielded controversial results. Three hundred-sixty subjects free of occlusive arterial disease were then examined by means of clinical and Doppler investigation in order to assess the semeiological reliability of the dorsalis pedis artery in the diagnosis of occlusive arteriopathy of lower limbs, when compared to the posterior tibial one. The conclusion is drawn that a greater semeiological reliability must be attributed to the latter, due to its lesser "absence" incidence.

Adolescent↗
PubMed1983

Effects of calcitonin on limb blood vessels in human obstructive arterial disease.

To check the possibility of a vasoactive effect of calcitonin in man, the authors treated ten hospitalized patients (seven males and three females, mean age 66.3 +/- 3.24), suffering from obstructive arterial disease in the lower extremities, with 100 units M.R.C. i.m. daily, for a period of 15 days. Five patients presented Raynaud's phenomenon. Treatment (B) led to an improvement of subjective symptomatology and to the disappearance of Raynaud's phenomenon in comparison with symptoms before treatment (A) and after a placebo period of 15 days (C). With respect to instrumental parameters, calcitonin induced: a) a slight increase of segmental plethysmography values (height/width ratio of curves) if compared with A (p less than 0.05) and more significantly if compared with C (p less than 0.01 and less than 0.0125, from right and left sides, respectively); b) a small change in venous-occlusion plethysmography values, if compared with A and C, both in basal conditions and after the "ischaemic test"; c) a significantly lesser reduction of digital photoelectric plethysmography values (height/width ratio of curves) after the "cold test" in comparison with A (p less than 0.01, both on the second and on the third fingers of the right hand), as well as with C (p less than 0.01 and p less than 0.025, on the second and on the third fingers, respectively). The present investigation points out the vasoactive influence of calcitonin in human obstructive disease. Results show the improvement in collateral limb circulation and, above all, in the amount of cutaneous flow. Little information is available on the mechanism of this effect, for which only hypotheses can at present be advanced.

Aged↗
PubMed1976

[Hemodynamic research and physiopathologic remarks on "vibration angiopathy" with Raynaud's phenomenon (author's transl)].

A hemodynamic research was carried out by the authors in ten patients affected with upper limb "vibration angiopathy", as well as in ten healthy control subjects. Digital artery flow and systolic, diastolic and mean pressures were measured, and vascular resistances and the so-called "systolic index" calculated, both in basal condition and following hand warming. In patients with "vibration angiopathy" fingers were examined, which on a previous arteriographic study showed the most and the least severe arterial lesions, respectively. No statistically significant differences were detected between the mean values of the hemodynamic indices obtained from the most and the least involved fingers, respectively, as well as between such values and the control subject ones. These results would suggest--even with due reservation on account of the relatively small number of cases and of their different features--that digital artery lesions, as shown by arteriography, have no definite hemodynamic significance. The lack of a statistically significant decrease of the digital artery mean pressure, compared to control subjects, supports the hypothesis that Raynaud's phenomenon in "vibration angiopathy" is not due to a transmural pressure fall. Finally, the lack of correlation between the severity of arterial lesions and Raynaud's phenomenon site suggests that the vasomotion impairment which causes the phenomenon is not related to such lesions.

Arteries↗