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Biomedical subjects

G Nouvet

Publications and source records attributed to G Nouvet.

At least 55 records · Page 3Linked to original sources
PubMed1987

Evolution of peripheral nerve function in hypoxaemic COPD patients taking almitrine bismesylate: a prospective long-term study.

Almitrine bismesylate has been thought to provoke peripheral neuropathies in patients with chronic obstructive pulmonary disease (COPD). However, there seems to exist alterations of peripheral nerve function in patients with COPD, who have not taken almitrine. We have therefore examined 22 patients with COPD and no other cause of peripheral neuropathy (PN), before and after 6 and 12 months of treatment with almitrine (50 mg bd). Seventy-eight similar patients, who did not take almitrine, were also studied (controls). Sixty-four per cent of controls, and 55% of almitrine patients initially had at least one neurophysiological abnormality. There was no change in the studied parameters after 6 months and one year's treatment with almitrine.

Aged↗
PubMed1987

[Surgery of intracranial metastases of bronchial origin].

Forty-six out of a series of 76 patients with intracranial metastases from lung cancer underwent a surgical operation for complete macroscopic resection. 44 cases presented with a single metastasis. In 2 cases, there were 2 cerebral metastases. Most of the lesions were situated in the frontal lobe (41%). In more than one half of cases, the primary lung cancer was squamous carcinoma. The mean survival was 9 months. It was shorter in the case of anaplastic cancers (6 months) and adenocarcinomas (8 months) than in the squamous carcinomas (12 months). The five patients still alive 2 years after surgery all belong to this histological group. The results suggest that surgical treatment of single cerebral metastases from lung cancer, in the absence of extracranial dissemination, allows a considerable improvement in the quality and duration of the survival.

Adenocarcinoma↗
PubMed1985

Preoperative chemotherapy in epidermoid bronchogenic carcinoma.

Palliative chemotherapy in cases of epidermoid bronchogenic carcinoma, initially judged to be inoperable, made it possible to perform operative resection in 50 cases. An association of cis-platinum and bleomycin was used, this combination having previously been considered synergistic. In certain cases the tumour seemed to have disappeared on macroscopic examination of the resected specimen, and in some instances no tumoral cells could be found on histological examination. This series brought out several positive features: chemotherapy made it possible to operate on patients previously judged to be inoperable; it ensured maximum local efficiency of drugs because of the absence of abnormal vascularity; and it made it possible to anticipate the cure of occult metastases. However, three negative aspects were also present: modification of postoperative TNM classification making it difficult to establish a prognosis; difficulty in determining therapeutic strategy for pNo; and inadequate long-term follow-up. On the whole the positive points appeared to outweigh the negative aspects, but a randomized study is necessary to confirm this.

Adult↗
PubMed1984

[Meteorological conditions and spontaneous pneumothorax. Retrospective study of 165 cases in the Rouen area].

The occurrence of a spontaneous "idiopathic" pneumothorax in 165 patients admitted to hospital could be precisely dated over a 5-year period. An analysis of the meteorological conditions recorded at these dates (mean atmospheric pressure, mean temperature, relative and absolute humidity) and of their seasonal distribution demonstrated two peaks of frequency, one in the summer, the other in the winter, and a significant correlation between the occurrence of pneumothorax and a low relative humidity. These results, particularly clear during the exceptionally dry summer of 1976, confirm some data in the literature and suggest that bronchoconstriction induced by moistening of air in the airways might play a role in the pathophysiology of pneumothorax.

Adult↗
PubMed1983

[Pulmonary arteriovenous aneurysm].

A case of large arteriovenous aneurysm in the right upper lobe of a 27-year old man is reported. The pulmonary angioma was responsible for a 30% shunt with hypoxia and polycythaemia but was only discovered while looking for the origin of a cerebral abscess. A few weeks after surgical treatment of the cerebral abscess, the right upper lobe was excised with immediate correction of the hypoxia. This case shows that pulmonary angiomas can sometimes be revealed by neurological complications, and that visceral angiomas should not remain undiagnosed. They should be considered as part of a Rendu-Osler disease, the familial character of which may contribute to an early diagnosis.

Adult↗
PubMed1983

[Poisoning by diazomethane inhalation].

A case of Diazomethane intoxication has been reported. Diazomethane is gaz commonly used by pharmacological and industrial chemist. This case of intoxication is rare, since only 15 other cases have been published up to now. A review of the literature leads leads describe the clinical feature of such an intoxication by gaz inhalation. When Diazomethane is inhaled it induces respiratory and general disorders. In some cases, it be fatal, and, in some other cases, when a second exposure happens, bronchial asthma may appear. Post mortem studies show pulmonary oedema lesions with important inflammatory reaction localized in the peribronchia. It must be emphasized that direct aggression is probably responsive of toxical discorders, but increase of the symptoms consecutive to a second exposure are related to allergical mechanisms.

Adult↗
PubMed1980

Sarcoidosis. Retroperitoneal fibrosis, renal arterial involvement, and unilateral focal glomerulosclerosis.

In one patient with pulmonary sarcoidosis, hypertension occurred during the course of the disease. Aortography showed extensive narrowing of the right renal artery. Surgical exploration disclosed extensive periaortic and perirenal fibrosis. This fibrosis encircled the right renal artery and caused extrinsic compression. Pathological examination disclosed a large amount of histiocyte epithelioid infiltration in various samples of the fibrosis and particularly in the adventitia of the renal artery, highly suggestive of sarcoidal angiitis. Surgical biopsy was performed on both kidneys. The right kidney, protected by arterial stenosis, was little altered, while the left kidney showed extensive interstitial, tubular, and glomerular lesions. The glomerular lesions were focal and segmental hyalinosis.

Adult↗