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Biomedical subjects

G Notter

Publications and source records attributed to G Notter.

At least 37 records · Page 2Linked to original sources
PubMed1976

Control of dose administered once a week and three times a day according to schedules calculated by the CRE formula, using skin reaction as a biological parameter.

Patients with breast cancer were irradiated postoperatively to bilateral parasternal fields. The validity of the Cumulative Radiation Effect (CRE) formula for treatment once a week and three times a day was analyzed, and both schedules were compared with treatment once a day (five times a week). The biological radiation effect on normal tissue was studied by reflectance spectrophotometry of skin erythema and pigmentation. Early skin reactions were identical after irradiation daily and once a week, respectively, but were found to be significantly more pronounced after irradiation three times a day than after treatment once a day, corresponding to an overexposure of 7-10%.

Breast Neoplasms↗
PubMed1976

Prospective studies with the CRE formula of prolonged fractionation schedules.

Different dose schedules prospectively calculated with the Cumulative Radiation Effect (CRE) formula were used for irradiation of inoperable breast carcinomas. Fractionation with 2 X 260 rad and 2 X 450 rad twice a week, and total doses corresponding to CRE levels 1900 to 2300, were compared. The results showed that prolonged fractionation increased the tolerance of normal skin and the therapeutic ration with respect to early radiation reactions. Late reactions could not be assessed as yet because their development requires several years. With the prolonged course of treatment and 2 X 260 rad per week, no moist desquamation developed despite dose levels between 6800 and 9400 rad. Skin reactions were milder than those in the rapidly treated areas, indicating that the CRE formula cannot exactly predict acute skin reactions for very prolonged treatment schedules. The tumor regressed continuously during the irradiation schedule.

Breast Neoplasms↗
PubMed1976

Anti-oestrogen therapy of advanced mammary carcinoma.

Forty mg daily of tamoxifen (Nolvadex) was administered orally to 89 patients with advanced soft tissue mammary carcinoma. At two months 43 per cent of the patients responded. At 6, 12 and 18 months, 42, 35 and 32 per cent, respectively, were still responding to therapy. The side effects were limited, fatique being the most frequent complaint. Oestrogen dependent side effects were not encountered. The therapeutic effect of tamoxifen is similar to that of oestrogen, but the side effects are less.

Administration, Oral↗
PubMed1976

Skin reaction as a biologic parameter for control of different dose schedules and gap correction.

In patients with mammary carcinoma, irradiated postoperatively on the parasternal regions, prospective dose calculations for different fractionation schedules have been performed with the CRE formula. The biologic radiation effect on normal tissue was recorded by reflectance spectrophotometry of skin erythema and pigmentation. The right side received 4 050 R in 25 days, the left side 4 390 R in 47 days with a gap of 3 weeks. A compensation for the gap with 8 per cent of the total exposure was found to be adequate. The smallest exposure difference that could be clearly discriminated visually and with spectrophotometry was recorded in a special series and was found to be 6 to 7 per cent.

Breast Neoplasms↗
PubMed1975

Hormonal treatment of mammary carcinoma with Progynon-Depot and Depostat.

The results of combined treatment with 90 mg estradiol valerianate and 300 mg 17-alpha-hydroxy-19-norprogesterone-capronate (SH 834) (3 ml once a week i.m.) in 117 cases with disseminated or inoperable mammary carcinoma are reported. Objective remissions of 3 to 36 months were obtained in 48 patients. Soft tissue, lung and pleura metastases responded more favourably than bone metastases. Liver and brain metastases were unaffected.

Adult↗
PubMed1975

Skin reactions after different fractionation schedules giving the same cumulative radiation effect.

The CRE formula was used for calculation of biologically equivalent radiation doses with different fractionation schedules. The early radiation effects, skin erythema and pigmentation were measured with a reflectance spectrophotometer at wavelengths 578 and 660 nm. The course and maximum for both erythema and pigmentation agreed well with the two types of fractionation. The results seem to justify further use of this simple formula.

Breast Neoplasms↗
PubMed1975

Treatment of disseminated carcinoma of the breast by metenolone enanthate.

Forty-three patients with disseminated or inoperable carcinoma of the breast were treated with Metenolone Enanthate (Primobolan Depot) with doses of 400 to 1 200 mg/week for at least 3 months. Objective remissions lasting longer than 3 months occurred in 8 out of 41 evaluable patients. Soft tissue metastases responsed best. Liver and brain metastases were unaffected. The therapeutic efficiency of Primobolan Depot is comparable to that of testosterone propionate but the agent is less virilising.

Aged↗