Biomedical subjects

G Nissen

Publications and source records attributed to G Nissen.

At least 19 recordsLinked to original sources

PubMed1992

Use of moclobemide in children with attention deficit hyperactivity disorder.

A monoamine oxidase hypothesis for the cause of attention deficit hyperactivity disorder has recently been established (Shekim et al. 1986). To test this, moclobemide, a new and reversible inhibitor of monoamine oxidase-A, was administered to 12 children between the ages of 6 and 13 years, diagnosed as attention deficit hyperactive according to DSM III-R, in a 4-week study. All had previously discontinued treatment with methylphenidate due to side-effects. A 40% improvement in parental assessment of children's behaviour occurred among those who received moclobemide as outpatients, and a 31% improvement among the five in-patients. There was a general increase in concentration and attention span at the end of the trial, but mood changes and explosive behaviour continued to be present at a low level. Brain mapping after moclobemide treatment showed an overall reduction in frontal lobe delta activity. Moclobemide was well tolerated by these patients, although two complained of mild gastrointestinal disturbances during the first week of therapy.

Adolescent↗

PubMed1992

Prevalence of sexual abuse of children in Germany.

A survey of the prevalence of sexual abuse of children in two different areas of Germany (Würzburg - former West Germany and Leipzig - former East Germany) was conducted using a multiple screen questionnaire. The sample consisted of 1841 students from different institutions in Würzburg and 310 students from vocational schools in Leipzig (n = 2151). Data on a similar number of males and females were recorded. Problems of definition, sample characteristics and methodology are discussed. Sexual abuse was reported by 16.1% of the women and 5.8% of the men in the Würzburg sample and 9.6% and 5.8%, respectively, in the Leipzig sample. More comparable subsamples showed less discrepancy in the prevalence rates for women in the two cities.

Adolescent↗

PubMed1992

[Pyromania and enuresis. Multifactorial causes require multidimensional treatment concepts].

The abilities to control the voiding of the bladder and to act competently in dealing with fire are important factors of the normal development of children. Unfavourable conditional constellations in the socio-emotional, cognitive, or physical realm can cause developmental defects which manifest themselves in certain target symptoms, for instance Pyromania and Enuresis. The importance of multifactorial etiological models will be illustrated by a case report of a boy displaying symptoms of Pyromania and Enuresis nocturna. The analysis of the specific conditions of the case studied results in the appropriate multidimensional treatment concept.

Affective Symptoms↗

PubMed1990

[Landau-Kleffner syndrome].

In 1957, Landau and Kleffner reported six cases of a "syndrome of acquired aphasia with convulsive disorder". Since this first report more than 130 cases with acquired language disabilities with EEG-abnormalities have been described. Comprehension of language is primarily affected, spike discharges are predominantly found in temporal regions. Facultative symptoms are epileptic seizures and psychiatric disorders. The paper gives a review of the literature describing the clinical manifestations, the therapeutic procedure, the prognosis and the etiological factors of this syndrome, which is even listed in the last version of the ICD-10 and the International Classification of Epilepsies and Epileptic Syndromes.

Adolescent↗

PubMed1979