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Biomedical subjects

G Nikolov

Publications and source records attributed to G Nikolov.

At least 37 records · Page 2Linked to original sources
PubMed1978

[Clinical trial of the preparation clofazolin used intravenously].

The authors studied the hypotensive effect of the Bulgarian preparation Chlophazolin in ampoules of 0,15 mg, administered i. v. The study covered 50 patients, 44 of them with hypertonic disease II and III stage and the rest (6)--with renal and renovasal hypertension. The i. v. administration of chlophazolin was established to have a marked hypotensive effect and be expedient for the treatment of hypertonic crises and hypertension with high values. In a dose of 0,15 mg i. v. the preparation leads to a sharp decrease in the first 20 min, whereas during the following hours it is kept to lower values: systolic pressure-an average decrease of 30-40 mm Hb in a lying position, to 45-50 mm Hg in an erect position; the diastolic pressure-an average decrease of 10-15 mm Hg in a lying position to 20-25 mm Hg in an erect position. The hypotensive effect is better manifested in higher initial values of the pressure. It lasts approximately more than 13 hours but in 1/5 of the patients, with higher values of blood pressure, its effect is exhausted within 6-8 hours. Side effects of the preparation were registered in 26 per cent of the cases; orthostatic disturbances, sleepiness, dryness of the mouth, nausea. I. v. administration of chlopazolin does not change the excretion of urea and creatinine, diuresis and serum levels of sodium, potassium and chlorine.

Adolescent↗
PubMed1977

[Cardiocirculatory complications and ECG changes in patients operated on for severe deformations of the anterior chest wall].

After a brief literature review on the indidence of these diseases, the authors present a comprehensive analysis of a group of 117 patients, operated and treated by them, for the period from 1968 t0 1975 includ. They discuss in details the cardiocirculatory complications and ECG changes in those patients undergone operations for severe deformities of the anterior chest wall. Their observations and results obtained are well illustrated in three tables. Furthermore, they try to explain why those electrocardiographic changes do no disappear after the carried out operation treatment. Finally, they propose the inclusion of a new stage in the operation treatment of these patients, being a significant contribution to the operation treatment and the definite elimination of ECG changes.

Adolescent↗
PubMed1976

[Indications for temporary and permanent cardiac electrostimulation].

The author suggests a classification of the indications for cardiac eletrostimulations based on the analysis of his own clinical observations upon a series of 308 patients, treated by different cardiac electrostimulation methods and upon literature date. The results of his observations are illustrated in four tables, after a brief review of the methods most frequently applied, taking in consideration their positive and negative aspects from a point of view of his observations in comparison to those found in the literature. At the end, practical conclusions are drawn for the proper application of that treatment in everyday clinical practice with a view to raising the problem of founding a department or centre for cardiac electrostimulation, due to the constant number increase of those patients and because this problem is not solved in our country so far.

Arrhythmias, Cardiac↗
PubMed1974

[The incidence and clinical characteristics of the postinfarct syndrome (Dressler's syndrome)].

After a brief review of the post infarction syndrome, the authors report the results from the examinations of 257 patients with myocardial infarctions and post infarction states, treated at the Therapeutic clinic for the last 10 years. They found post infarction syndrome in 12 patients--4,8 per cent. Six of the patients--2,4 per cent--were with a complete clinical picture and six patients--2,4%--were with a frustrate form. In two of the patients, the syndrome developed as early as the first week and in the rest--10--between the first and the eighth week post infarction onset. The most frequent, almost compulsory symptoms of the syndrome were: febrility, leukocytosis, accelerated erythrocyte sedimentation, followed by chest pains, pericarditis, pleuritis and pneumonia. tnine of the patients were established to have anterior or anterolateral infarction and only three were with infarction of the posterior wall. With respect to the infarction severity, preceding the syndrome--two patients were with a light infarction form; four with moderately severe and six--with severe. The authors stress upon the particular importance of the combination of the syndrome with heart aneurysm post myocardial infarction, observed in two of the patients. At the end they accentuate on the diagnostic difficulties, caused by the syndrome.

Heart Aneurysm↗