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Biomedical subjects

G Nielsen

Publications and source records attributed to G Nielsen.

At least 37 records · Page 2Linked to original sources
PubMed1993

Antithrombotic properties of a truncated recombinant tissue factor pathway inhibitor in an experimental venous thrombosis model.

The aim of this study was to investigate whether a truncated recombinant tissue factor pathway inhibitor (rTFPI1-161) had an antithrombotic effect comparable to low-molecular-weight (LMW) heparin. A randomized double-dummy study was conducted with 40 rabbits in 6 groups. An experimental thrombosis was induced in the jugular veins by a combination of destroyed endothelium and restricted blood flow. Group 1 was given placebo; group 2, LMW heparin 60 anti-factor Xa units/kg; group 3, rTFPI1-161 0.1 mg/kg; group 4, rTFPI1-161 1.0 mg/kg and group 5, rTFPI1-161 10.0 mg/kg. rTFPI1-161 reduced the thrombus weights in all treated groups, with a significant effect in doses between 1.0 and 10.0 mg/kg compared to placebo. The frequency of thrombosis was significantly reduced in all treated groups. No hemorrhagic side effects were noted. In conclusion, rTFPI1-161 (1.0-10.0 mg/kg) has an antithrombotic effect comparable to that of LMW heparin.

Animals↗
PubMed1993

Continuous blood gas monitoring in haemodialysis using an electrode inserted in the extracorporeal dialysis circulation.

The aim of this study was to evaluate the usefulness of continuous gas monitoring during haemodialysis using an oxygen- and carbon dioxide-sensitive electrode inserted in the 'arterial' line from the arteriovenous fistula. We investigated 15 patients with chronic renal failure, treated with regular bicarbonate haemodialysis. The PO2 and PCO2 were measured by the new method and compared to conventional blood gas analysis of the 'arterial' blood from the dialysis circulation. We found the in situ gas sensors were stable and there was no systematic difference between gas tensions measured by in situ and conventional blood gas measurements. The standard deviations of the difference between paired measurements for PO2 and PCO2 were 1.3 and 0.4 kPa, respectively. Therefore, the method can be used to detect major changes in blood gas tensions during haemodialysis.

Adult↗
PubMed1992

[Relationship between distal systolic blood pressure and wound healing. A retrospective study of patients with crural ulcers].

To anticipate the need for ensuring quality in treatment of patients with ulceration of the lower leg and complicating arterial occlusive disease, three authors examined the files of 56 patients with systolic digital blood pressure (SDBP) below 60 mmHg, all admitted to the geriatric in-patient department over a 11-year period in a retrospective study. In 40 patients (71%) the ulcer healed. Eight patients (14%) required amputation, six patients (11%) died and two patients (4%) were unsolved. We found a significant correlation between SDBP and ulcer healing (p = 0.006). In patients with SDBP < or = 35 mmHg, healing on conservative pharmacotherapy was demonstrated even with critical ischaemia.

Aged↗
PubMed1992

Madelung deformity: surgical prophylaxis (physiolysis) during the late growth period by resection of the dyschondrosteosis lesion.

The majority of cases of Madelung deformity are caused by hereditary dyschondrosteosis at the wrist. The principal lesion in the ulnar zone of the distal radial physis retards growth asymmetrically, especially in late childhood. Resection of this zone and its replacement with autologous fat (Langenskiöld procedure, or physiolysis) restores growth and minimizes deformity. The resection of an abnormal ligament tethering the lunate proximally may assist carpal advancement. A series of 17 patients (24 wrists) treated over a 12-year period is presented, with sufficient follow-up for evaluation of 11 patients (15 wrists). The results of this prophylactic procedure are encouraging, and, if it is performed early, the authors believe that Madelung deformity may be preventable, or at least controllable.

Adipose Tissue↗
PubMed1992

Serum methylmalonic acid before and after oral L-isoleucine loading in cobalamin-deficient patients.

Over a 1 1/2-year period, we measured concentrations of methylmalonic acid in serum before and after a standardized loading with oral L-isoleucine (100 mmol) in 13 patients admitted for evaluation of cobalamin deficiency. All patients had serum cobalamin values below 100 pmol l-1, but only 12 of the 13 patients were clinically confirmed cobalamin deficient. The clinically non-cobalamin-deficient patient had folate deficiency and was excluded. The serum methylmalonic acid concentrations before loading with isoleucine were above the upper reference limit (0.37 mumol l-1) in all the patients and L-isoleucine caused an increase in serum methylmalonic acid of more than 1.00 mumol l-1 in 11 of the 12 deficient patients. In the remaining patient the increase was 0.35 mumol l-1. The results show that a significant increase of an initially elevated serum methylmalonic acid concentration after isoleucine loading is a general finding in tissue cobalamin deficiency which strongly supports the diagnosis.

Administration, Oral↗
PubMed1991

[Continuous arteriovenous hemodialysis in acute renal insufficiency. Review of therapeutical results among 23 patients treated over a period of 2 years].

In critically ill patients with acute renal failure and unstable circulation, dialysis employing conventional haemodialysis may prove technically difficult. If, however, continuous arterio-venous haemofiltration is employed, the haemodynamic problems may be overwon but the method does not always provide effective control of azotaemia. Continuous arterio-venous haemodialysis (KAVHD) is a combination of ultrafiltration and dialysis. The efficacy of KAVHD was investigated retrospectively in 23 critically ill patients with acute renal failure and unstable circulation. All of the patients achieved acceptable steady state concentrations for serum creatinine and carbamide. Four out of five patients with hyperkalaemia obtained normal serum potassium after the first 24 hours of treatment with KAVHD. The average filtration volume was 6.1 1/24 hours, sufficient to provide parenteral nutrition and intravenous infusion and to maintain the negative fluid balance simultaneously. Fifteen patients (65%) died during the intensive course of treatment but none died from complications of KAVHD or renal failure. Renal function was reestablished in eight patients and seven of these could be discharged alive. KAVHD is an effective and simple method of treating critically ill patients with acute renal failure and unstable circulation.

Acute Kidney Injury↗
PubMed1990

[Attitude to the criteria of death and kidney transplantation of the relatives of kidney donors].

Fifty near relatives of cadaver kidney donors in the County of Ringkøbing were questioned about how they experienced information concerning the brain death of the donor and the request for permission to remove the kidneys for transplantation. This was undertaken as an interview investigation. In addition, they were questioned as to whether they subsequently experienced doubt about the decision and about their attitude to the criteria for death. It was found that approximately half were aware of the seriousness of the condition before they were told by a doctor but that 35% would have desired more detailed information. Emphasis is placed, in addition, on improved conditions for a dignified parting from the decreased, not information by telephone and that the time for decision making was too short. The reasons for accepting removal of the kidneys were either knowledge of the donor's attitude or consideration of the recipient. Only three donors had drawn up donor testaments. Only one of the relatives regretted the decision while 20% had experienced doubts but the great majority would have liked to discuss the subject with others later. 63% accept the criteria for brain death and 14% the criteria for heart death but only 9% have altered their attitude as a result of the current debate.

Attitude to Death↗