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Biomedical subjects

G Nicoletti

Publications and source records attributed to G Nicoletti.

At least 289 records · Page 16Linked to original sources
PubMedDate not supplied

[Interference of the intestinal ecosystem of mice in the oral administration of lyophilized live bacteria].

Oral vaccines mode by living or killed bacteria are commonly used to restore normal intestinal flora; it's not well know, however, which bacteria play the leading part in this ecosystem. In the present paper Authors have intended to compare the effectiveness of an oral vaccine, made by Bifidobacterium bifidus and Lactobacillus acidofilus, with another of similar use, made by Enterococci, to increase the mouse resistance to lethal Salmonella enteritidis infections. According to collected microbiological data and M.E.S. photos, the association Bifidob./Lactobac. is more effective than Enterococci to enhance resistance to the experimental infection.

Administration, Oral↗
PubMedDate not supplied

[Bactericidal and potent antiadhesive activity of sulbenicillin].

Sulbenicillin, a wide broad spectrum penicillin, is active against a lot of gram positive and gram negative bacteria. The AA. studied the activity of this molecule against urinary infections causing germs, by evaluating two parameters: his antiadhesive capability and the Killing curves, in comparison with mezlocillin and piperacillin. An inhibition in adhesive capability of test-germs, due to sulbenicillin was obtained. Furthermore, resulting Killing curves showed more rapidity in action for sulbenicillin than for the two others molecules, versus resistant germs, like P. aeruginosa and S. faecalis.

Bacterial Adhesion↗
PubMedDate not supplied

Evaluation of antinfective activity of an association bifidobacterium/lactobacillus in mouse intestine.

The present research aimed at studying the action of an association of Bifidobacterium bifidum and Lactobacillus acidophilus, in controlling an experimental severe infection by Salmonella enteritidis administered in mouse per os. The behaviour of some parameters was undertaken, checking for the pH of intestinal content; the condition of the colonization in the intestinal wall by means of scanning electron microscopy and plates cultures; the presence of antibodies IgA in intestinal content; the index of mortality in the diversely treated animal's groups. The reported data show a string incidence of the administration of Bifidobacterium and Lactobacillus in increasing the animal's resistance against the lethal infection.

Animals↗
PubMedDate not supplied

Are colony-stimulating factor-producing cells facilitated in the metastatic process?

The relationship between production of Colony-Stimulating Factor (CSF) and metastasis has been investigated in the TS/A murine model. CSF production was determined in TS/A cell variants isolated through serial in vivo selection of lung metastatic nodules induced by intravenous or subcutaneous injection of tumor cells (artificial and spontaneous metastases, respectively). All the cell variants selected for high artificial metastatic ability produced higher amounts of GM-CSF in vitro and stronger haematological alterations in vivo than cells obtained by serial selection of spontaneous metastases. Our data suggest that the late, rather than the early, steps of the metastatic process could be enhanced by GM-CSF production.

Animals↗
PubMedDate not supplied

In vitro comparative study of RU 28965 against organisms from oral and vaginal flora.

The Authors studied the activity of RU 28965, a new macrolide antibiotic, in comparison whith erytromycin, josamycin, miocamycin, ampicillin and rifampicin against oral streptococci (45 strains), coryneform bacteria (23 strains) and G. vaginalis (15 strains). Minimum inhibitory concentrations (MIC), minimum bactericidal concentrations (MBC) and the effect of inoculum size on MICs were determined. RU 28965 showed better activity than the other macrolides. The MICs of RU 28965 were eightfold higher than the corresponding MICs. The MICs of RU 28965 showed up to 10 fold increase by increasing the inoculum density from 10(3) to 10(7) CFU/ml.

Ampicillin↗