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Biomedical subjects

G Nichols

Publications and source records attributed to G Nichols.

At least 55 records · Page 3Linked to original sources
PubMed1984

Histamine uptake and metabolism in the blood vessels of rats.

In vitro radiolabeled histamine uptake and metabolism were investigated in abdominal aorta, iliac artery, mesenteric artery and hepatic portal vein of the rat. Histamine uptake was rapid and remained linear over the initial 10 min of the accumulation period. The uptake rate was temperature sensitive with marked reduction in rate at 0 degrees C. The accumulation at 0 degrees C represents nonspecific uptake. The uptake of histamine was observed to be related to the amount of tissue stores of histamine as well as extracellular sodium ion concentration. The only histamine metabolite detected in the vasculature examined was imidazoleacetic acid representing almost 80% of the chromatogram radioactivity. This observation indicates the primary metabolic pathway for histamine in rat vasculature involves the enzyme, diamine oxidase.

Animals↗
PubMed1983

Skin antisepsis during steady-state hyperbaric exposure and subsequent decompression.

A custom-made container for the transfer of bacteriological sampling pads was used in a trial to test the feasibility of human skin disinfection during saturation or steady-state diving and subsequent decompression. Analysis of the results of colony counting and typing from 6 days of pre- and postcleansing samples taken during a recent saturation dive indicates that the skin of hyperbaric chamber occupants can be effectively sterilized in the event of a need to prepare for anesthetic or surgical procedures while still under pressure. A separate survey was also made to establish any pattern of change in bacterial flora of the chamber interior during the trial. Results of this survey are briefly discussed.

Antisepsis↗
PubMed1981

The intramuscular neurovascular anatomy of the latissimus dorsi muscle: the basis for splitting the flap.

This study identifies and describes a consistent proximal branching of the neurovascular supply to the latissimus dorsi muscle. This anatomical feature makes possible splitting the muscle and overlying cutaneous territory into independent branched musculocutaneous units. A parallel study of neurovascular anatomy in dogs suggests that this animal is an appropriate model for testing and developing clinical applications of the split latissimus dorsi flap.

Anatomy, Comparative↗
PubMed1981

A pilot study of skin disinfection in the hyperbaric environment.

An opportunity was taken to carry out a pilot on human skin disinfection during a recent long-term saturation dive at extremely high pressure. Despite a number of difficulties, results were sufficiently encouraging to suggest that, given ideal conditions, sterilization of the skin in preparation for surgical or anesthetic procedures, or both, in a hyperbaric environment is possible.

Atmospheric Pressure↗
PubMed1978

Femoral hypoplasia-unusual facies syndrome, from another viewpoint.

A female infant with the "femoral hypoplasia-unusual facies" syndrome is presented. Most of the findings observed in this child have also been described in the "caudal regression syndrome". The similarity and probable identity between these two syndromes is discussed on the basis of our patient and others from the literature.

Abnormalities, Multiple↗
PubMed1978

Synthesis and antiinflammatory activity of some 1,2,3- and 1,2,4-triazolepropionic acids.

All possible "nonadjacent" phenyltriazolepropionic acids were synthesized and tested for antiinflammatory activity. Two of the isomers displayed activity approximately equal to phenylbutazone: the 4-phenyl-1,2,3,-triazole-2-propionic acid (7) and its reverse counterpart, 2-phenyl-1,2,3-triazole-4-propionic acid (6). The other five isomers were inactive. Since these seven acids are geometrically congruent and possess similar lipophilic characters, antiinflammatory activity must depend on some property that is a function of how the carbon and nitrogen atoms are arranged in the triazole ring.

Animals↗