Somatomedin C in rheumatoid arthritis.
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Biomedical subjects
Publications and source records attributed to G Newton.
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In a consecutive series of 87 operations for knee replacement prospective observations were made of the pattern of articular destruction in the form of a triangle of erosion or osteophyte formation, which is seen on the medial femoral condyle, sometimes with an associated strip on the lateral femoral condyle. These areas represent the surfaces which are normally in contact with the anterior horns of the menisci when the knee is fully extended. The lesions in question were found only in association with a flexion contracture in 84 out of the 87 cases.
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Neurological involvement in fluorosis occurs in the advanced stage of the disease and is due to compression of the spinal cord and/or nerve roots. There are only a few reports on the role of surgical management of these cases in the medical literature. Five cases of fluorosis from the endemic areas of Uttar Pradesh, India, had associated cervical cord compression. Their mean age was 43 yr (range 35-50), and all cases were manual laborers. Three patients with blocked cervical subarachnoid space on myelography underwent laminectomy using local anesthesia. All three cases improved significantly after surgery. The usefulness of laminectomy in selected cases of cervical cord compression due to fluorosis is suggested.
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