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Biomedical subjects

G Newman

Publications and source records attributed to G Newman.

40 records · Page 3Linked to original sources

[Acts of violence from point of view of the criminologist].

Assaultive offences continue to occupy a major share of the interest of criminologists and of the attention of the public. They are defined by the use, or the threat of use of force on a victim by an offender. The paper reviews basic definitions, methods of measuring assaultive crime, and recent phenomenological patterning. Different socio-economic variables are discussed, such as age and sex, urbanization and social class, race, victim-offender relationships, family factors. A brief analysis is presented of child abuse. Various theories have been presented, with different interpretative and explanatory focuses. They are summarized by the Authors under the following headings: a) Barrier theories b) Theories of inevitability c) "Bad influence" theories d) Culture theories. A few cross-cultural examples are given, from existing studies. The postulates of cultural theories are presented, with suggestions for further research.

Aggression↗

An improved blood substitute. In vivo evaluation of its hemodynamic effects.

The purpose of the present study was to assess the ability of an improved free hemoglobin based blood substitute to serve as a resuscitative fluid in the treatment of hemorrhagic shock. Comparison studies were performed by using blood autotransfusion as a positive control. The hemodynamic parameters studied included cardiac index, mean arterial pressure, pulse pressure, heart rate, stroke volume index, and total peripheral resistance. Tissue oxygenation was measured in the biceps femori muscle by polarography. Hemorrhagic shock (at 40% of the total blood volume) in anesthetized rats caused severe disturbances in hemodynamic parameters and tissue oxygenation. Shock was characterized by a 66% drop in cardiac index, a 67% drop in mean arterial pressure with a significant increase in total peripheral resistance, and a 78% reduction in tissue oxygenation, all lasting 30 min. Resuscitation from shock with the blood substitute was effective in restoring hemodynamic parameters, producing vasodilation, and improving tissue oxygenation. Autotransfusion with blood also restored hemodynamics. However, lower tissue oxygenation and lack of vasodilation were noted. Therefore, the modified hemoglobin solution yielded better results than blood in the resuscitation of rats after hemorrhagic shock. The vasodilatory activity and the reduction of vasoconstriction that followed hemorrhage can be primarily linked with adenosine, which possesses vasodilatory and anti-inflammatory properties, and is used in our technology as an intermolecular cross linking reagent and hemoglobin surface modifier.

Animals↗