Hemorrhagic shock was experimentally induced in 40 mongrel dogs, and the resulting pulmonary vascular resistances studied. A mechanical test with closure of the left branch of the pulmonary artery and two pharmacological tests with isoproterenol (isuprel) and cyclic adenosine-monophosphate (cAMP) were performed. The results suggest that there is a block in the beta-control during prolonged shock, and that beta-control is restored by cAMP.

Animals↗

PubMedDate not supplied

[Cancer of the penis. Review of 17 cases].

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Adult↗

PubMedDate not supplied

Clinical problems of the transplanted kidney.

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Graft Rejection↗

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[Experimental model of induction in the rat of rapidly developing biliary cirrhosis in peripartal nodular cirrhosis].

The treatment with CCl4 and progesterone subsequent the common biliary duct ligature induced, in the rat, after 4-5 weeks, a cirrhotic picture characterized by an early and strong biliary epithelium proliferation followed by a perilobular fibrosis with a concentric sclerosis as in true perilobular cirrhosis.

Animals↗

PubMedDate not supplied

Some characteristics of the residue obtained after pronase treatment of sheep erythrocyte membranes. I. Protein and phospholipid patterns.

In this note some data regarding analysis of sheep erythrocyte stromata after pronase treatment are reported. The membrane material obtained after pronase treatment was analyzed by density gradient ultracentrifugation, gel filtration, acrylamide gel electrophoresis and for phospholipid content. With all techniques employed two major lipo or glycolipopeptides can be observed. The whole body of phospholipids is not lost after pronase treatment, therefore lipid-lipid interactions are maintained after pronase treatment, moreover sodium dodecyl sulphate is not efficient in the breakdown of some protein-lipid interactions. The results are discussed in view of the correspondence of the two fractions obtained with portions of the major glycoproteins of the erythrocyte membranes.

Animals↗

PubMedDate not supplied

Some characteristics of the residue obtained after pronase treatment of sheep erythrocyte membranes. II. Carbohydrate patterns.

The composition of single carbohydrate classes of intact and pronase treated sheep erythrocyte membranes has been studied. In comparison with the data obtained from untreated stromata after proteolytic digestion the amount of each class of sugars is decreased. A high disappearance of sialic acids and hexosamines can be observed. Nevertheless if the total sugar content is referred to the residual protein content (16% of the native proteins, an enrichment in carbohydrates, specially neutral hexoses, can be observed. The results indicate that most of the carbohydrate fractions solubilized by pronase treatment are sialic acids and hexosamines. Different molar ratios obtained for the single carbohydrate classes in comparison with NANA before and after pronase treatment suggest a microheterogeneity of the glycoprotein structure of sheep erythrocyte membranes. By the use of several analytical methods the residue obtained after pronase treatment shows two major fractions containing proteins, lipids and carbohydrates. The data are discussed in view of the possible arrangement of lipo-glycoproteins in sheep erythrocyte membrane.

Animals↗