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Biomedical subjects

G Nagy

Publications and source records attributed to G Nagy.

At least 145 records · Page 8Linked to original sources
PubMed1989

A controlled multicentre therapeutic trial to determine the efficacy of a novel antacid (AI-Mg-hydroxy-carbonate) in duodenal ulcer.

Tisacid (a new, modern Hungarian AI-containing antacid) with a high acid-neutralizing capacity (greater than 26.8 mmol/g) also enhances gastric mucosal defense mechanisms (prostaglandin-dependent gastroprotection). A simple-blind, prospective, randomized, parallel multicentre clinical trial has been performed on both the clinical efficacy and possible side-effects of Tisacid monotherapy (AI-Mg-hydroxy-carbonate) on informed patients suffering from active duodenal ulcers. The four study groups were as follows: Group A: 3 g/day of Tisacid (acid-neutralizing capacity = 78 mmol, n = 85), Group B: 6 g/day of Tisacid (acid-neutralizing capacity = 156 mmol, n = 88), Group C: 12 g/day of Tisacid (acid-neutralizing capacity = 312 mmol, n = 68), Group D (as control): 1.0 g/day cimetidine (n = 91). The total number of patients was 332. It was found that the new Hungarian antacid compound (both tablet and suspension) can essentially accelerate the healing rate of duodenal ulcers; the cumulative healing rate of ulcers and the decrease of complaints can be achieved equally by relatively low doses of Tisacid monotherapy and cimetidine alone; and there were no essential differences between the clinical potency and side-effects of Tisacid tablets or the suspension.

Adolescent↗
PubMed1989

Treatment of duodenal ulcers by antacid (Al-Mg-hydroxy-carbonate). A controlled, randomized, prospective, multicentre clinical trial.

TISACID (a new, modern Hungarian Al-containing antacid) with a high acid-neutralizing capacity (greater than 26.8 mmol/g) also enhances gastric mucosal defense mechanisms (prostaglandin-dependent gastroprotection). A simple-blind, prospective, randomized, parallel multicentre clinical trial has been performed on both the clinical efficacy and possible side effects of TISACID monotherapy (Al-Mg-hydroxy-carbonate) on informed patients suffering from active duodenal ulcers. The study groups were as follows: Group "A": 3 g/day of TISACID (acid-neutralizing capacity = 78 mmol, n = 85), Group "B": 6 g/day of TISACID (acid-neutralizing capacity = 156 mmol, n = 88), Group "C": 12 g/day of TISACID (acid-neutralizing capacity = 312 mmol, n = 68), Group "D": (as control): (1.0 g/day cimetidine (HISTODIL, RGH, Budapest, n = 91). The total number of patients: 332. It was found that: 1. The new Hungarian antacid compound (both tablet and suspension) can essentially accelerate the healing rate of duodenal ulcers. 2. The cumulative healing rate of ulcers and the decrease of complaints can be achieved equally by relatively low doses of TISACID monotherapy and cimetidine alone. 3. There were no differences between the clinical potency and side-effects of TISACID tablet and suspension.

Adolescent↗
PubMed1989

Experimental paratuberculosis (Johne's disease)--studies on biochemical parameters in cattle.

Ten male Holstein-Friesian calves naturally infected by Mycobacterium paratuberculosis were experimentally re-infected orally at an average of 17 days. Monthly measurements were conduced of the following activities, in the period between post infection days 160 and 400: total protein (TPR), albumin (ALB), cholesterol (CHOL), triglycerides (TRIG), Zn and Cu concentrations as well as sorbitol dehydrogenase, lactate dehydrogenase (LDH), alpha-hydroxybutyrate dehydrogenase (alpha-HBDH), gamma-glutamyltransferase, aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatine kinase (CK), alkaline phosphatase and fructose-1,6-diphosphate aldolase (ALD). TPR, ALB, TRIG, and CHOL were reduced by day 400, in conjunction with disorders of digestion and absorption. Increased activities of CK, ALD, LDH, alpha-HBDH, AST and ALT primarily indicated damage to skeletal muscle and/or liver. Serum CK and ALD activities as well as TRIG and TPR concentrations may serve as aids to specific diagnosis of paratuberculosis, particularly in the advanced stage of the disease.

Animals↗
PubMed1988

The glycopeptide moiety of vasopressin-neurophysin precursor is neurohypophysial prolactin releasing factor.

All of the classically-described hypothalamic, hypophysiotropic factors that regulate anterior pituitary hormone secretion have now been isolated and identified except for prolactin releasing factor. We report here that the 39-amino acid glycopeptide comprising the carboxyterminus of the neurohypophysial vasopressin-neurophysin precursor stimulates prolactin release from cultured pituitary cells as potently as does thyrotropin releasing hormone but has no effect on the secretion of other pituitary hormones. Furthermore, antisera to the glycopeptide administered to lactating rats attenuated suckling-induced prolactin secretion. Thus, this glycopeptide appears to be the neurohypophysial prolactin releasing factor.

Animals↗
PubMed1988

Autocrine control of prolactin secretion by vasoactive intestinal peptide.

The functions of vasoactive intestinal polypeptide (VIP) and the many other neuropeptides that are localized in the anterior pituitary gland remain unknown although VIP of hypothalamic origin is established to act as a PRL-releasing factor. Evidence is presented here that locally-produced VIP acts in an autocrine fashion to stimulate PRL release. VIP antibodies or a VIP antagonist profoundly but reversibly suppressed PRL secretion in primary cultures of rat pituitary cells or the GH3 cell line. This evidence was obtained with the use of a reverse hemolytic plaque assay for microscopic demonstration of PRL release from individual cells under conditions precluding cell-cell interaction. We suggest that most of the high rate of "spontaneous" PRL secretion attributed to lactotropes deprived of hypothalamic influence is due in fact to the stimulatory effects of VIP acting in an autocrine fashion.

Animals↗
PubMed1988

Bilateral renal tumours with reference to the reoperation of a solitary kidney resected for tumour.

A case of bilateral renal tumour is reviewed, where the disease was detected by sonography performed for screening. On one side, nephrectomy, while on the other, partial resection of the kidney were performed in two sessions. Due to occlusion and a resultant renal fistula produced by scar tissue following the second operation as well as to progressive azotaemia, reoperation of the solitary kidney resected for tumour became necessary. As a result of the failure of both cytostatic and radiotherapy, the authors believe that, in similar cases, every surgical method possible should be used for prolonging the patient's life. In the available literature no reference has been found on the reoperation of solitary kidney resected for malignant tumour.

Adenocarcinoma↗
PubMed1987

Epidemiology and significance of Q fever in Hungary.

In Hungary, Coxiella (C.) burnetii infections were diagnosed for the first time in 1956 in a few dairy and sheep farms. Q fever associated with abortion was first demonstrated in 1983 during laboratory diagnostic examination of fetuses and placentae. From case history data and on-the-spot investigations it is clear that in cattle stocks abortion caused by C. burnetii occurs sporadically, whereas in sheep flocks numerous abortions may take place within a short time. Losses caused by Q fever on the affected large-scale farms amount to 5-15%, which arise partly from reduced calf or lamb crop and partly from the death of offspring born with poor viability and being highly susceptible to neonatal disease. Altogether 87 cases of human disease caused by C. burnetii have been reported in the Hungarian literature. Instead of typical pneumonia, in recent years sporadic cases of granulomatous hepatitis were a constant finding accompanied by a characteristic blood picture and high titres of specific antibodies.

Abortion, Veterinary↗
PubMed1986

Circadian corticosterone rhythm did not develop in rats seven weeks after destruction with 5,7-dihydroxytryptamine of the serotoninergic nerve terminals in the suprachiasmatic nucleus at the age of 16 days.

In order to study the role of the serotoninergic innervation of the hypothalamic suprachiasmatic nucleus (SCN) in the development of the circadian rhythm of corticosterone 5,7-dihydroxytryptamine (5,7-DHT) selectively destroying the serotoninergic structures was injected into the cell group of 16-day-old male rats prior to the appearance of the corticosterone rhythm. Rats treated with 5,7-DHT did not show circadian fluctuations in plasma corticosterone concentrations 3, 5 and 7 weeks after the injection of the neurotoxin. Their hypothalamo-pituitary-adrenal system responded to ether stress. Immunocytochemistry revealed that only a very few serotonin immunoreactive elements were visible in the SCN of the 5,7-DHT-treated rats. The results indicate that serotoninergic innervation of the SCN is essential for the development of the corticosterone rhythm.

5,7-Dihydroxytryptamine↗
PubMed1986

Episodic prolactin and growth hormone secretion not related to the actual suckling activity in lactating rats.

In order to characterize the secretion pattern of prolactin and GH in freely behaving lactating rats, frequent serial blood samples were collected through indwelling atrial cannulae and their prolactin and GH concentrations determined by radioimmunoassay. At the time of blood sampling, physical contact with the pups was recorded. Plasma prolactin and GH levels showed episodic changes which were independent of each other and there was no apparent correlation between hormone levels and contact between mother and pups. The data suggest that there are episodic fluctuations in plasma prolactin and GH concentrations in lactating rats. These changes do not appear to be closely correlated with the proximity of the mother to her pups.

Animals↗