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Biomedical subjects

G N Pershin

Publications and source records attributed to G N Pershin.

At least 91 records · Page 5Linked to original sources
PubMedDate not supplied

[Effect of dioxidine on DNA and RNA synthesis in Staphylococcus aureus].

The effect of dioxidin on DNA and RNA synthesis by Staphylococcus aureus was studied with the use of labeled precursors and evaluated from the kinetics of DNA and RNA accumulation by the culture. It was shown that dioxidin inhibits DNA synthesis by Staphylococcus aureus cells, with the synthesis of RNA being almost not affected. The main effect manifests within the first hour of the drug interplay with the microbial cell, it is reversible and appears to be realized by the mechanisms of DNA synthesis regulation. Dioxidin does not form complexes or cross-linkages with the DNA molecule. The action of dioxidin on the microbial cell manifests in the derangement of the activity and biosynthesis of extracellular DNase.

Anti-Bacterial Agents↗
PubMedDate not supplied

[Effect of bonaphthone on embryogenesis in white rats and mice].

Results of testing the embryotropic activity of bonaphthone used in different doses (700; 400; 100; 50 and 2 mg/kg) are reported. With its oral introduction to pregnant rats bonaphthone, given in doses at the level of the therapeutid one (2 mg/kg) and exceeding it by as much as 25 times (50 mg/kg), was found not to produce any damaging effect on the fetus. With its action in doses of 100 and 400 mg/kg a slight embryotoxic effect was noted. In the sublethal dose of 700 mg/kg the preparation displays a moderate embryotoxic action and produces a number of circulatory changes in the fetuses. It is concluded that bonaphthone displays no teratogenic properties.

Administration, Oral↗