Biomedical subjects
G N Kryzhanovsky
Publications and source records attributed to G N Kryzhanovsky.
The stereotyped behavior syndrome: a new model and proposed therapy.
The stereotyped behavior syndrome was induced in rats through local impairment of inhibitory GABA-ergic mechanisms in both caudate nuclei by bilateral microinjection of tetanus toxin, penicillin, or picrotoxin into the rostral part of the caudate nucleus. Intraperitoneally injected haloperidol suppressed the syndrome; this effect was dose-dependent. The same effect on the tetanus toxin-induced stereotyped behavior was produced by GABA microinjected bilaterally into the rostral part of the caudate nucleus of unrestrained rats. It was found in this model of tetanus toxin-induced stereotyped behavior that lithium chloride and diazepam can suppress the syndrome. Combined application of lithium chloride, diazepam, and haloperidol in minimal effective doses resulted in a much more complete and longer-lasting suppression of the syndrome than the separate use of these drugs. This effect is attributed to the joint specific actions of the drugs on pathogenetically interrelated components of a hyperactive determinant structure that arises in the caudate nuclei after impairment of the GABA control and this is responsible for the stereotyped behavior syndrome.
Descending supraspinal effects under conditions of disturbance of the inhibitory processes in the nuclei of the medulla: the formation of the generators of excitation.
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Present data on the pathogenesis of tetanus.
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Tetanus: general and pathophysiological aspects; achievements, failures, perspectives of elaboration of the problem.
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The mechanism of action of tetanus toxin: effect on synaptic processes and some particular features of toxin binding by the nervous tissue.
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Descending supraspinal effect in tetanus intoxication of the spinal cord.
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Antiepileptic properties of cerebrospinal fluid after activation of the antiepileptic system of the brain.
Intraventricular injection of cerebrospinal fluid (CSF) obtained from cats with chronic electrical stimulation of cerebellar vermal cortex resulted in suppression of epileptic foci activity in cat brain cortex, an increase in time to first seizure, and weakening of generalized seizures in rats. The CSF obtained from cats after electroshock seizures induced less pronounced, although significant antiepileptic action in comparison with the CSF of cats with cerebellar stimulation on the model of generalized seizures in rats. The antiepileptic action of CSF obtained from cats with electrostimulation of cerebellar vermis and from electroshock cats is due to appearance of peptide factors in CSF.