[Comparative evaluation of two models of hemosiderosis for analysis of iron chelators].
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Animals↗
Biomedical subjects
G N Kol'tsova
Publications and source records attributed to G N Kol'tsova.
[Use of chelates for removal of excess iron from the body].
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Administration, Oral↗
[Immunopathology and histochemistry of malignant serous ovarian tumors].
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Adult↗
[Diphosphonate dextran derivatives: their interaction with hemoglobin].
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Animals↗
[Synthesis and properties of an organophosphorous regulator of hemoglobin oxygenation].
Racemic 1-O-(epsilon-aminohexanoyl)-2,3-diphosphoglycerol (ADPG) was synthesized. The pH dependence of the 31P-NMR spectra was studied for the ADPG cyclohexylammonium salt. ADPG binding to hemoglobin and its functional activity as a regulator of human hemoglobin reversible oxygenation were assayed.
Chemical Phenomena↗
[Synthesis and analysis of glycol bis-phosphates, regulators of reversible hemoglobin oxygenation].
Bisphosphates of glycols, ethyleneglycol and 1,2-propanediol, were synthesized. These structural analogues of 2,3-diphosphoglyceric acid were shown to reduce significantly the oxygen affinity of stripped hemoglobin.
Allosteric Regulation↗
[Synthetic models of erythrocytes--hemosomes].
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Biological Transport↗
[Biologically active hydroxamic acids--iron complexons].
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Animals↗
[Hemoglobin interaction with organophosphorus compounds].
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Adenosine Triphosphate↗
[Organophosphorus compounds as regulators of reversible hemoglobin oxygenation].
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Hemoglobins↗
[Clinical picture of hormone-producing tumors of the ovaries].
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Adolescent↗
[Use of desferal in anemia, myeloid leukemia and other pathological conditions].
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Anemia, Sickle Cell↗
[Phototransformation of porphyrins in frozen solutions. Oxidative medium].
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Electron Spin Resonance Spectroscopy↗
[A comparative study of the antioxidant properties of polyhydroxamic acids, desferal and other iron chelating agents].
The effects of different iron chelators on both OH.-generation in Fenton reaction and lipid peroxidation products accumulation in brain homogenate were studied. Intensity of luminol-dependent chemiluminescence was the measure of OH.-radical generation. The rate of lipid peroxidation was estimated as malondialdehyde accumulation. It was shown, that inhibition of chemiluminescence by the tested substances increased in next series: ADP, polyhydroxamic acid (PHA), EDTA, desferal, o-phenanthroline, ascorbate. Inhibition of lipid peroxidation by these substances increased in other order: ADP, Ascorbate, EDTA, PHA, desferal, o-phenanthroline. The results obtained allow to conclude, that antioxidant activity of ascorbate is due to the trapping of OH. radicals; in contrast, inhibition of the free radical processes by other tested substances is due to binding of iron ions. Antioxidant effect of PHA is almost as strong as effects of desferal, o-phenanthroline and EDTA. The lowest antioxidant activity was found in the presence of ADP.
Antioxidants↗