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Biomedical subjects

G N Fox

Publications and source records attributed to G N Fox.

At least 37 records · Page 2Linked to original sources

Varicella-zoster virus infections in pregnancy.

Varicella-zoster virus can cause a distinct congenital syndrome, a potentially fatal neonatal infection and life-threatening maternal illness. Physicians can reduce morbidity from these conditions by advising nonimmune pregnant women to avoid exposure to chickenpox and herpes zoster and, when indicated, by promptly administering varicella-zoster immune globulin. When prevention fails, acyclovir may be effective therapy.

Abnormalities, Multiple↗

Pruritic folliculitis of pregnancy.

Pruritic folliculitis of pregnancy may appear any time after the fourth month of gestation. This distinct dermatosis is characterized by pruritus and small, follicle-centered, erythematous papules that may be excoriated or may have the appearance of small pustules. Distribution is variable, although all reported cases have included the abdomen. There is an absence of systemic maternal or fetal toxicity, and the condition resolves spontaneously after delivery. The cause of this dermatosis is unknown.

Adult↗

Single-dose therapy for genitourinary infections.

Single-dose therapy for selected genitourinary tract infections is an effective alternative to multiple-dose regimens. Candidal vulvovaginitis and trichomonal vaginitis may be routinely treated with single-dose regimens. With acute cystitis, candidates for single-dose therapy include patients who have a short duration of symptoms and are likely to comply with follow-up.

Acute Disease↗

Restless legs syndrome.

Patients with restless legs syndrome often have difficulty describing their symptoms. Three features characterize the classic syndrome: an unusual, almost indescribable sensation in the lower extremities; an irresistible urge to move the legs, and the exclusive occurrence of the symptoms at rest, with their relief by movement. Restless legs syndrome may cause severe insomnia. Variants of the syndrome, as well as numerous associated conditions, have been described. The etiology is unknown. Clonazepam and carbamazepine are reported to be effective in treating this syndrome.

Adolescent↗

Neonatal myotonic dystrophy associated with prenatal ventriculomegaly. A case report.

Myotonic dystrophy is an autosomal dominant neuromuscular disease in which the maternal manifestations may be mild or subclinical. However, the congenital form, transmitted only from affected mothers, is reported to have a neonatal mortality rate as high as 50%. Ultrasonographic features of pregnancies with affected fetuses include hydramnios and decreased fetal movement, breathing motion and swallowing. Several reports have also noted an occasional infant with ventriculomegaly or hydrocephalus. It appears that prenatal ventriculomegaly may also be an occasional ultrasonographic finding heralding neonatal myotonic dystrophy.

Adult↗

Pruritic urticarial papules and plaques of pregnancy.

Pruritic urticarial papules and plaques of pregnancy (PUPPP) is a distinct dermatosis characterized by onset in the third trimester. Lesions generally begin on the abdomen, particularly in the striae distensae. Primigravidas are disproportionately affected by this dermatosis. There is no associated fetal or maternal morbidity. Etiology and pathogenesis are unknown. The natural history is one of spontaneous resolution, and most patients respond well to symptomatic treatment with topical corticosteroids.

Adult↗