Search PubMed⌕ Search

Biomedical subjects

G Mozes

Publications and source records attributed to G Mozes.

25 records · Page 2Linked to original sources
PubMedDate not supplied

"Floating tibia-talus complex"--an ipsilateral dislocation of the knee and the subtalar joint in an elderly patient: a case report and review of the literature.

Knee dislocation is defined as a radiographically confirmed total loss of the tibiofemoral articulation. This rare injury is believed to be the result of a high-impact trauma. Knee dislocations are classified according the direction of tibial displacement with respect to the femur. Subtalar dislocation is the simultaneous dislocation of the distal articulations of the talus at both the talocalcaneal and talonavicular joints. These injuries are also quite rare and are mostly (80%-85%) classified as medial subtalar dislocations with the calcaneus lying medially, the head of the talus being prominent dorsolaterally and the navicular located medial and dorsal to the talar head. The authors report the case of an elderly patient who suffered ipsilateral anterior dislocation of his left knee and medial subtalar dislocation of his left foot. The authors believe this to be the first presentation in the English literature of an ipsilateral combination of these two injuries on the same limb.

Aged↗
PubMedDate not supplied

L-arginine availability is not limiting for nitric oxide generation from recombinant endothelial nitric oxide synthase.

L-arginine (L-Arg) may be limiting for inducible nitric oxide synthase (NOS) activity and under certain circumstances, such as increased concentrations of a NOS inhibitor, may also be limiting for endothelial NOS activity. It is unknown if L-Arg is limiting for recombinant eNOS activity in the vascular wall after adenoviral mediated gene transfer. Our aim was to examine, if L-Arg is limiting for recombinant eNOS activity in the normal or atherosclerotic vessel wall. Rings of rabbit aorta from chow or cholesterol fed animals were transduced with adenovirus vector encoding eNOS (AdeNOS) or beta-galactosidase (AdbetaGal). After 24 h, transgene expression was confirmed and vasomotor studies were performed in the absence or presence of L-Arg. During maximal contractions to phenylephrine (10(-5) M), L-Arg (3 mM) was added to the organ chamber for 30 min. Subsequently, relaxations to acetylcholine during half-maximal contractions were obtained. In the chow- and cholesterol-fed animals, relaxations were significantly enhanced in the NOS and NOS + L-Arg groups compared to the betaGal and betaGal + L-Arg groups. There was no difference between NOS and NOS + L-Arg or betaGal and betaGal + L-Arg rings from chow- or cholesterol-fed animals. While gene transfer of eNOS enhances endothelium-dependent vasorelaxation in the normal and atherosclerotic vessel wall, L-arginine is not limiting for recombinant eNOS activity.

Animals↗
PubMedDate not supplied

Mineral and endocrine metabolism during fracture healing in dogs.

The blood levels of parathormone (PTH), calcitonin (CT), vitamin D metabolites, calcium, phosphate, magnesium and alkaline phosphatase (AKP) were determined in 13 young dogs with experimental fractures of long bones. The parameters were measured before the fracture and during healing until the appearance of an early callus. Serum Ca levels were significantly reduced immediately after the fracture (10.95 +/- 0.30 mg/dl to 10.25 +/- 0.25 mg/dl; p less than 0.05). Significant rises in serum levels of PTH (0.99 +/- 0.10 ng/ml to 1.57 +/- 0.22 ng/ml; p less than 0.01); CT (0.14 +/- 0.01 ng/ml to 0.18 +/- 0.01 ng/ml; p less than 0.05); 24,25-dihydroxyvitamin D (13 +/- 2 ng/ml to 19 +/- 3 ng/ml; p less than 0.01) and AKP (153 +/- 24 U/l to 211 +/- 26 U/l; p less than 0.01) were noted during fracture repair. A reduction in serum levels of 25-hydroxyvitamin D (22 +/- 2 ng/ml to 15 +/- 1 ng/ml; p less than 0.001) was noted at the same time. The parameters returned or tended to return to normal levels during callus development. The data demonstrate the changes in levels of Ca-regulating hormones in response to bone injury. This suggests that CT and 24,25-dihydroxyvitamin D (24,25-(OH)2-D) can be associated with the process of callus formation.

Alkaline Phosphatase↗